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Does intravenous vitamin C, hydrocortisone and thiamine in addition to standard treatment, improve mortality in ICU patients with severe sepsis or septic shock, compared with standard treatment alone?
Continue reading »A compendium of critical appraisals in Intensive Care Medicine research and related specialties
Does intravenous vitamin C, hydrocortisone and thiamine in addition to standard treatment, improve mortality in ICU patients with severe sepsis or septic shock, compared with standard treatment alone?
Continue reading »In patients with septic shock, does the use of intravenous vitamin C and thiamine compared to standard therapy improve recovery from organ failure?
Continue reading »Does treatment with vitamin C, hydrocortisone, and thiamine lead to a more rapid resolution of septic shock compared with hydrocortisone alone?
Continue reading »Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial Fowler AA. JAMA; 2019;322(13):1261-1270 Clinical Question In patients with sepsis and acute respiratory distress syndrome, can intravenous administration of vitamin C, compared to placebo, reduce organ failure scores and biomarkers of inflammation and vascular injury? […]
Continue reading »In patients with septic shock, does the administration of thiamine lead to more rapid lactate clearance and improved clinical outcomes?
Continue reading »In adult critically ill patients receiving pharmacological thromboprophylaxis, does the use of adjunctive intermittent pneumatic compression devices result in a lower incidence of proximal deep vein thrombosis (DVT)?
Continue reading »In patients with septic shock, do corticosteroids compared to placebo reduce mortality?
This is an editorial blog post in anticipation of the ADRENAL trial results to be presented at #CCR18.
In fluid responsive spontaneously breathing critically unwell patients undergoing resuscitation, does the collapsibility of the inferior vena cava (cIVC), as determined by point of care ultrasound (POCUS), when compared to administering a fluid bolus predict a >10% increase in cardiac output?
Continue reading »In patients with septic shock who are mechanically ventilated does indexed LV end-diastolic area and respiratory changes in aortic blood velocity predict the haemodynamic effects of volume expansion?
Continue reading »In mechanically ventilated patients with subarachnoid hemorrhage (SAH), does the distensibility of IVC on ultrasound, predict fluid responsiveness measured by thermodilution?
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