SPICE III
In ventilated, critically ill patients, does the use of dexmedetomidine as the primary sedative agent compared with usual sedative agents effect 90 day mortality?
Continue reading »A compendium of critical appraisals in Intensive Care Medicine research and related specialties
In ventilated, critically ill patients, does the use of dexmedetomidine as the primary sedative agent compared with usual sedative agents effect 90 day mortality?
Continue reading »In patients with septic shock, does early low-dose norepinephrine compared with standard care increase shock control at six hours?
Continue reading »In mechanically ventilated, critically ill patients receiving enteral nutrition does energy-dense feed (1.5kCal/ml) compared with routine feed (1kCal/ml) impact on 90 day all cause mortality?
Continue reading »In patients with severe blunt traumatic brain injury (TBI) does early and sustained cooling compared with standard care improve neurological outcomes at 6 months?
Continue reading »In critically ill patients on noradrenaline for haemodynamic support, who required hemofiltration for AKI, does the use of a high cutoff hemofilter compared with a standard hemofilter impact the median hours of noradrenaline-free time at day 7?
Continue reading »For surrogate decision makers of critically ill patients, does a multi-component family support intervention impact on the surrogates’ hospital anxiety and depression scale (HADS) at 6 months?
Continue reading »In patients with sepsis, critical illness, stroke, trauma, myocardial infarction, cardiac arrest and those who had emergency surgery does a liberal oxygen strategy compared with a conservative oxygen strategy increase hospital mortality?
Continue reading »In critically ill patients does the administration of balanced crystalloids compared with saline, reduce a 30 day composite outcome of death, new renal replacement therapy or persistent renal dysfunction?
Continue reading »In adult critically ill patients, with acute kidney injury, does early initiation of RRT compared to delayed initiation of RRT reduce the composite endpoint of MAKE365; consisting of death, RRT and persistent renal dysfunction at one year?
Continue reading »In patients undergoing cardiac surgery, who have a moderate-to-high risk of death, does a restrictive transfusion strategy compared with a liberal strategy impact on a composite outcome of death, myocardial infarction, stroke and acute kidney injury requiring dialysis
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