In this Editorial, Professor Imelda Galvin from Queen’s University in Canada takes us through the details of Power, how it relates to trial sample size, and why it matters.Continue reading »
In patients with septic shock, do corticosteroids compared to placebo reduce mortality?
This is an editorial blog post in anticipation of the ADRENAL trial results to be presented at #CCR18.
It’s been another big year for research in ICM, EM and Peri-operative Care. What do the TBL editors think are the best trials of 2017?Continue reading »
P-values – interpreting the evidence seriesContinue reading »
Rather than reinvent the wheel, we are delighted to include a link to the RCEM Critical Appraisal Dictionary. The RCEM learning site provides excellent open access educational resources, including critical care appraisal modulesContinue reading »
In statistical hypothesis testing, a type I error is the incorrect rejection of a true null hypothesis (a “false positive”), while a type II error is incorrectly retaining a false null hypothesis (a “false negative”). The more you try and avoid a Type I error (false positive), the more likely a Type II error (false negative) may happen. Researchers have found that an alpha level of 5% is a good balance between these two issuesContinue reading »
Fragility Index is the minimum number of patients whose status would have to change from a “non-event” (not having the primary endpoint) to an “event” (having the primary end point) in order to turn a statistically significant result to a nonsignificant result. It is a simple metric to calculate and use.
Reporting the Fragility Index in RCTs may help readers make more informed decisions about the confidence warranted by RCT resultsContinue reading »
Slides and handout from the the ‘Critical Care Game Changers’ (updates in critical care) presentation at Critical Care Symposium 2017Continue reading »
All of us on the editorial team would like to wish our subscribers, followers and readers our very best wishes for this festive season and the year ahead.
We’re taking our usual two week break, and we shall return in 2017 with more #FOAMed.Continue reading »
We’ve covered five key papers from a range of researchers with a focus on Point-of-Care Ultrasound. This has been complemented by the excellent ‘Introduction to…’ blog posts from Adrian and Segun.Continue reading »