Category: Intensive Care Medicine

A collection of TBL summaries relevant to Intensive Care Medicine

PREPARE II

Effect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation @DerekRussellMD. JAMA; 328(3):270-279. doi:10.1001/jama.2022.9792 Clinical Question In critically ill adult patients undergoing tracheal intubation and positive pressure ventilation, does intravenous infusion of a 500ml fluid bolus vs no fluid bolus, decrease the incidence of cardiovascular collapse during, or shortly after the procedure? Background Tracheal intubation […]

Pro-MEDIC

19 December 2022 George Walker Intensive Care Medicine Leave a comment

In adults with an expected ICU stay of > 72 hours, does the provision of enteral melatonin compared to placebo increase the number of delirium-free assessments within 14 days or before ICU discharge?

TEAM

9 December 2022 George Walker Intensive Care Medicine, Summaries Leave a comment

Early Active Mobilization during Mechanical Ventilation in the ICU @chodgsonANZICRC @TEAMtrialICU. NEJM 2022; 387:1747-58 doi:10.1056/NEJMoa2209083 Clinical Question In mechanically ventilated adult patients does the provision of early mobilisation when compared to standard care increase the number of days alive and out of hospital at 180 days? Background ICU Acquired weakness (ICUAW) is common with one systematic review reporting a median […]

PILOT

2 December 2022 Omar Jundi Intensive Care Medicine 2 comments

Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation Semler. N Engl J Med 2022; 387:1759-1769. DOI: 10.1056/NEJMoa2208415 Clinical Question In patients receiving invasive mechanical ventilation, does a target oxygen saturation of 90%, 94%, or 98% increase days alive and free of mechanical ventilation at 28 days? Background Despite the ubiquity of oxygen therapy in the critical care setting, the […]

TBL Mini: Rib Fixation

14 November 2022 George Walker Intensive Care Medicine, Summaries Leave a comment

Operative vs Nonoperative Treatment of Acute Unstable Chest Wall Injuries: A Randomised Clinical Trial Dehghan et al. JAMA Surg 2022 doi:10.1001/jamasurg.2022.4299 Background Blunt chest wall trauma has high associated rates of morbidity and mortality RCTs have shown a reduced ICU length of stay in those requiring mechanical ventilation, however this has not been replicated in non-ventilated patients What did they […]

SuDDICU

11 November 2022 George Walker Intensive Care Medicine Leave a comment

In mechanically ventilated adults, does the addition of selective decontamination of the digestive tract (SDD) compared to standard care reduce all-cause hospital mortality within 90 days?

DOSEVF

10 November 2022 David Slessor Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

In patients with refractory VF, does Double Sequential External Defibrillation or Vector-change Defibrillation improve survival to hospital discharge?

BOX (Oxygen)

8 November 2022 David Slessor Intensive Care Medicine, Summaries Leave a comment

In comatose patients following cardiac arrest does a restrictive compared with a liberal oxygenation strategy, reduce death or survival at discharge with a poor neurological outcome?

BOX Trial: Blood Pressure

14 October 2022 Alastair Brown Intensive Care Medicine, Summaries Leave a comment

Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest Kjaergaard et al | New England Journal of Medicine| August 2022 DOI: 10.1056/NEJMoa2208687 Clinical Question In patients with return of spontaneous circulation (ROSC) after cardiac arrest does a higher MAP target (> 77mmHg) compared to a standard target (>63mmHg) reduce death or survival at discharge with a poor neurological status? Background Manipulation […]

Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis

23 September 2022 George Walker Intensive Care Medicine, Summaries 2 comments

In adults with acute pancreatitis does aggressive fluid resuscitation compared to moderate resuscitation result in a reduction in the development of moderately severe or severe pancreatitis?

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