A compendium of critical appraisals in Intensive Care Medicine research and related specialties
A category to collect all the summaries, so that they can be used in menus and widgets. Please don’t expand this – “Specialties” and “Special Topics” have been created as a custom category sets for the clinical topics.
In patients with acute coronary syndromes without ST elevation, does clopidogrel + aspirin, compared with aspirin alone, reduce a composite outcome of death from cardiovascular causes, acute myocardial infarction and stroke?
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In patients with septic shock who are treated with corticosteroids, does tight glycaemic control (4.44–6.1 mmol/l) compared with less-tight glycaemic control (<8.3 mmol/l) reduce in-hospital mortality?
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In patients with moderate to severe acute respiratory distress syndrome (ARDS) does use of a lung recruitment maneuver associated with positive end-expiratory pressure (PEEP) titration according to the best respiratory-system compliance, compared with a conventional low-PEEP strategy, decrease 28-day mortality?
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In mechanically ventilated patients, does the early administration of simvastatin compared to placebo reduce the incidence of brain dysfunction (delirium and / or coma)?
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In high-risk patients undergoing angiography, does the administration of bicarbonate and/or acetylcysteine, compared with placebo, prevent major adverse events and acute kidney injury?
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In patients undergoing cardiac surgery, who have a moderate-to-high risk of death, does a restrictive transfusion strategy compared with a liberal strategy impact on a composite outcome of death, myocardial infarction, stroke and acute kidney injury requiring dialysis
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In Zambian adults with sepsis and hypotension, does a resuscitation protocol implemented early after presentation to the Emergency Department improve in-hospital mortality compared with usual care?
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In critically ill patients aged over 75 years, does a recommendation for systematic ICU admission compared with standard care reduce 6 month mortality?
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In critically ill patients undergoing emergency intubation, does the ramped position compared to sniffing position reduce the incidence of oxygen desaturation?
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In critically ill patients undergoing intubation, does the use of a pre-intubation checklist compared to no checklist prevent oxygen desaturation or systolic hypotension?
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