ICU-ROX
In mechanically ventilated ICU patients does a conservative use of oxygen therapy compared to usual oxygen therapy affect the number of ventilator-free-days?
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UK-ROX Trial
Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients Martin. JAMA June 12 2025; doi:10.1001/jama.2025.9663 Clinical Question In mechanically ventilated adult patients in the ICU, does a strategy of conservative oxygen therapy, targeting a SpO2 of 90% (Range 88-92%) compared with usual care, reduce mortality at 90 days? Background In the United Kingdom, around 184,000 adults are admitted to […]
Continue reading »BOX (Oxygen)
In comatose patients following cardiac arrest does a restrictive compared with a liberal oxygenation strategy, reduce death or survival at discharge with a poor neurological outcome?
Continue reading »COAST
In hypoxic African children (oxygen saturations of between 80 and 91%) with pneumonia, does oxygen therapy reduce mortality when compared with a permissive hypoxia (no oxygen) strategy?
In severely hypoxic children (oxygen saturations less than 80%), does high-flow nasal therapy reduce mortality when compared with low-flow oxygen therapy?
Young
Conservative oxygen therapy for mechanically ventilated adults with suspected hypoxic ischaemic encephalopathy Young P. 2020; 46(12):2411-2422. Clinical Question In mechanically ventilated adults patients with suspected hypoxic ischaemic encephalopathy does conservative oxygen therapy when compared with usual oxygen therapy decrease the risk of dying or surviving with an unfavourable neurological outcome at 180 days? Background Oxygen is often used liberally in […]
Continue reading »HOT-ICU
In patients with acute hypoxaemic respiratory failure, does a lower vs higher oxygenation target reduce mortality at 90 days?
Continue reading »LOCO2
In patients with acute respiratory distress syndrome (ARDS), does conservative vs. liberal oxygen reduce death at 28 days?
Continue reading »IOTA
In patients with sepsis, critical illness, stroke, trauma, myocardial infarction, cardiac arrest and those who had emergency surgery does a liberal oxygen strategy compared with a conservative oxygen strategy increase hospital mortality?
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