Aniket Nadkarni

BIHCA – Sodium Bicarbonate for In-Hospital Cardiac Arrest

7 September 2026 Aniket Nadkarni Uncategorized Leave a comment

Sodium Bicarbonate for In-Hospital Cardiac Arrest Granfeldt A. JAMA 2026; doi:10.1001/jama.2026.10628 Clinical Question In adults with in-hospital cardiac arrest, does sodium bicarbonate administration during arrest, improve return of spontaneous circulation, compared with placebo? Background Inpatient cardiac arrest is relatively common and outcomes are poor despite the rapid provision of hospital-based advanced life support. Severe acidemia during cardiac arrest may impair […]

Sodium Bicarbonate for Metabolic Acidosis in the Intensive Care Unit (SODa-BIC) trial

29 June 2026 Aniket Nadkarni Intensive Care Medicine, Uncategorized Leave a comment

Sodium Bicarbonate for Metabolic Acidosis in the Intensive Care Unit (SODa-BIC) trial The SODa-BIC Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. NEJM 2026; doi: 10.1056/NEJMoa2600526 Clinical Question In critically ill adults with metabolic acidosis (pH < 7.30) receiving vasopressors, does sodium bicarbonate decrease the risk of major adverse kidney events within 30 days compared […]

FARES II: PCC vs FFP in Cardiac Surgery

23 May 2025 Aniket Nadkarni Intensive Care Medicine, Summaries Leave a comment

Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery The FARES-II Multicenter Randomized Clinical Trial Karkouthi. JAMA 2025; doi:10.1001/jama.2025.3501 Clinical Question In adults undergoing cardiac surgery with cardiopulmonary bypass, is the use of a 4-factor prothrombin complex concentrate (PCC), compared to fresh frozen plasma (FFP), safe and efficacious in treating active or anticipated bleeding? Background Bleeding post […]

ALBICS-AKI

23 December 2024 Aniket Nadkarni Intensive Care Medicine Leave a comment

Postoperative 20% Albumin Infusion for Acute Kidney Injury in High-Risk Cardiac Surgery. Shehabi et al.. JAMA Surgery 2025; doi:10.1001/jamasurg.2025.1683 Clinical Question Amongst patients undergoing high risk cardiac surgery, does the administration of 20% Human Albumin Solution, compared to standard care, reduce the risk of post-operative acute kidney injury? The primary outcome was the occurrence of stage 1-3 AKI […]

ARiE Trial – Rifaximin for encephalopathy

1 March 2024 Aniket Nadkarni Intensive Care Medicine, Summaries Leave a comment

In critically ill adults with overt acute hepatic encephalopathy (HE) admitted to ICU, does the addition of rifaximin to broad spectrum antimicrobials affect time to resolution of HE?