Tag: Cardiac Arrest

LOGICAL – Conservative Oxygen after Cardiac Arrest

Conservative Oxygen for Unresponsive Patients after Cardiac Arrest The LOGICAL Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. NEJM. 2026. doi: 10.1056/NEJMoa2513814 Clinical Question In patients who are unresponsive after cardiac arrest, does limiting oxygen exposure to achieve acceptable oxygenation increase the likelihood of surviving with a favourable functional outcome Background Brain damage and unfavourable […]

Pupillometry Thresholds for Neuroprognostication

22 November 2024 stephen.waite2@nhs.scot Intensive Care Medicine, Summaries Leave a comment

Validating quantitative pupillometry thresholds for neuroprognostication after out‑of‑hospital cardiac arrest. A predefined substudy of the Blood Pressure and Oxygenations Targets After Cardiac Arrest (BOX)‑trial Nyholm. Intensive Care Med 2024; 50:1484–1495. doi.org/10.1007/s00134-024-07574-6 Clinical Question In adult out-of-hospital cardiac arrest (OHCA) survivors of presumed cardiac cause who are comatose post-admission, do automated pupillometry thresholds of quantitatively assessed pupillary light reflex (qPLR) < […]

PREOXI Trial – Noninvasive Ventilation for Preoxygenation

20 July 2024 Celia Bradford Emergency Medicine, Intensive Care Medicine One comment

In critically ill patients undergoing tracheal intubation does pre-oxygenation with non-invasive ventilation compared with pre-oxygenation with an oxygen mask reduce the incidence of hypoxemia during intubation?

Validation of the MIRACLE 2 Score for Prognostication After OOHCA

22 March 2024 David Slessor Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

In patient with out-of-hospital cardiac arrest, how does the MIRACLE2 score compare with previously reporting scoring systems, for predicting poor neurological outcome at hospital discharge?

Expedited transfer to a cardiac arrest centre for non-ST-elevation out-of-hospital cardiac arrest (ARREST)

6 September 2023 andrew.achilleos@nhs.net Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

In patients with non-ST elevation out-of-hospital cardiac arrest, does expedited delivery of patients to a cardiac arrest centre, compared with delivery to the geographically closest hospital, improve all-cause mortality at 30 days?

TAME

19 June 2023 George Walker Evidence-based Medicine, Intensive Care Medicine Leave a comment

In patients resuscitated from out-of-hospital cardiac arrest (OOHCA) does targeted mild hypercapnia compared to targeted normocapnia improve 6-month neurological outcomes?

INCEPTION

27 February 2023 Aidan Burrell Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

In patients with refractory out-of-hospital cardiac arrest (OHCA) and an initial ventricular arrhythmia, does extracorporeal cardiopulmonary resuscitation (ECPR), as compared with conventional CPR (CCPR), improve survival with a favourable neurologic outcome

DOSEVF

10 November 2022 David Slessor Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

In patients with refractory VF, does Double Sequential External Defibrillation or Vector-change Defibrillation improve survival to hospital discharge?

BOX (Oxygen)

8 November 2022 David Slessor Intensive Care Medicine, Summaries Leave a comment

In comatose patients following cardiac arrest does a restrictive compared with a liberal oxygenation strategy, reduce death or survival at discharge with a poor neurological outcome?

BOX Trial: Blood Pressure

14 October 2022 Alastair Brown Intensive Care Medicine, Summaries Leave a comment

Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest Kjaergaard et al | New England Journal of Medicine| August 2022 DOI: 10.1056/NEJMoa2208687 Clinical Question In patients with return of spontaneous circulation (ROSC) after cardiac arrest does a higher MAP target (> 77mmHg) compared to a standard target (>63mmHg) reduce death or survival at discharge with a poor neurological status? Background Manipulation […]

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