Pupillometry Thresholds for Neuroprognostication

Validating quantitative pupillometry thresholds for neuroprognostication after out‑of‑hospital cardiac arrest. A predefined substudy of the Blood Pressure and Oxygenations Targets After Cardiac Arrest (BOX)‑trial Nyholm. Intensive Care Med 2024; 50:1484–1495. doi.org/10.1007/s00134-024-07574-6 Clinical Question In adult out-of-hospital cardiac arrest (OHCA) survivors of presumed cardiac cause who are comatose post-admission, do automated pupillometry thresholds of quantitatively assessed pupillary light reflex (qPLR) < […]

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BOX Trial: Blood Pressure

Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest Kjaergaard et al | New England Journal of Medicine| August 2022 DOI: 10.1056/NEJMoa2208687 Clinical Question In patients with return of spontaneous circulation (ROSC) after cardiac arrest does a higher MAP target (> 77mmHg) compared to a standard target  (>63mmHg) reduce death or survival at discharge with a poor neurological status? Background Manipulation […]

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