A compendium of critical appraisals in Intensive Care Medicine research and related specialties
Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation Semler. N Engl J Med 2022; 387:1759-1769. DOI: 10.1056/NEJMoa2208415 Clinical Question In patients receiving invasive mechanical ventilation, does a target oxygen saturation of 90%, 94%, or 98% increase days alive and free of mechanical ventilation at 28 days? Background Despite the ubiquity of oxygen therapy in the critical care setting, the […]
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In critically ill patients with acute altered level of consciousness and no recent seizures, does continuous EEG (cEEG) compared to repeated routine EEG (rEEG) correlate with reduced mortality?
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In patients discharged from a general ICU, is discharge “out-of-hours” compared to discharge “in-hours” associated with subsequent in-hospital mortality?
Continue reading »Pulmonary Artery Catheters in patient Management PAC-MAN study group, Lancet 2005;366;472-477 Clinical Question In critically ill patients, does the use of a pulmonary artery catheter (PAC) reduce mortality? Design Randomised controlled trial Non-blinded Stratified by age and presumptive clinical syndrome Intention to treat analysis Power calculation: 1281 patients would allow detection of a 10% change in absolute hospital mortality, with […]
Continue reading »In high-risk patients undergoing gastrointestinal surgery, does a cardiac output-guided haemodynamic therapy algorithm compared to clinician-guided standard therapy reduce death and major morbidity within 30 days?
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