Tag: Trauma

TRAUMOX2 – Early Restrictive vs Liberal Oxygen for Trauma Patients

Early Restrictive vs Liberal Oxygen for Trauma Patients Arleth. JAMA 2024. doi: 10.1001/jama.2024.25786 Clinical Question In adult patients experiencing blunt or penetrating trauma does an early restrictive oxygen strategy compared to a liberal oxygen strategy reduce death and/or major respiratory complications within 30 days? Background ATLS guidelines recommend that all severely injured patients should receive supplemental oxygen in the initial […]

TRAIN – Transfusion Strategies in Acute Brain Injured Patients

26 October 2024 andrew.achilleos@nhs.net Intensive Care Medicine, Summaries Leave a comment

Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury @fabio_taccone. JAMA. 2024. PMID: 39382241 Clinical Question In patients with acute brain injury, does a liberal, compared to a restrictive strategy of blood transfusion, improve neurological outcomes at 180 days? Background The TRICC study, published over 20 years go, led to the widespread adoption of restrictive thresholds for blood […]

HEMOTION – transfusion thresholds in TBI

24 June 2024 Celia Bradford Intensive Care Medicine One comment

Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury Turgeon AF. NEJM June 13 2024; doi:10.1056/NEJMoa240360 Clinical Question In adult patients with moderate or severe traumatic brain injury, does a liberal transfusion strategy (transfusion if haemoglobin <10g/dl) compared to a restrictive strategy (transfusion if haemoglobin <7g/dl) reduce the rate of an unfavourable Glasgow Outcome Scale – Extended, at […]

Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage

24 October 2023 Celia Bradford Emergency Medicine, Intensive Care Medicine Leave a comment

In trauma patients with exsanguinating haemorrhage, does the use of the REBOA (resuscitative endovascular balloon occlusion of the aorta) device with standard care in the emergency department, compared with standard care alone, impact 90-day-mortality?

Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury

18 October 2023 Celia Bradford Emergency Medicine, Intensive Care Medicine, Peri-operative Medicine, Summaries Leave a comment

In patients with trauma and critical bleeding who require activation of a major haemorrhage protocol, does the empiric administration of 3 pools of cryoprecipitate (6g fibrinogen) within 90 minutes of randomisation (and no more than 3 hours after injury) improve survival, compared to standard care?

PATCH

19 June 2023 Celia Bradford Emergency Medicine, Intensive Care Medicine Leave a comment

In adult patients with major trauma, who are at risk for trauma-induced coagulopathy does early administration of 1g of tranexamic acid (TXA) followed by an infusion of 1g over 8 hours, compared with placebo, increase survival with a favourable functional outcome at 6 months?

TBL Mini: Rib Fixation

14 November 2022 George Walker Intensive Care Medicine, Summaries Leave a comment

Operative vs Nonoperative Treatment of Acute Unstable Chest Wall Injuries: A Randomised Clinical Trial Dehghan et al. JAMA Surg 2022 doi:10.1001/jamasurg.2022.4299 Background Blunt chest wall trauma has high associated rates of morbidity and mortality RCTs have shown a reduced ICU length of stay in those requiring mechanical ventilation, however this has not been replicated in non-ventilated patients What did they […]

DECRA

8 April 2022 George Walker Intensive Care Medicine, Summaries Leave a comment

In patients admitted to ICU with severe diffuse traumatic brain injury (TBI) and refractory raised intracranial pressure (ICP), does early decompressive craniectomy improve functional outcomes when compared with continued medical management?

RePHILL

1 April 2022 Celia Bradford Emergency Medicine, Intensive Care Medicine Leave a comment

In patients with trauma-related haemorrhagic shock does prehospital administration of packed red cells and lyophilised plasma (Lyo-Plas) compared with normal saline reduce the composite outcome of mortality and failure to reach lactate clearance?

COBI

15 July 2021 Fraser Magee Intensive Care Medicine, Summaries One comment

In adult patients with moderate to severe traumatic brain injury, does a continuous infusion of 20% saline, compared with standard care along, improve neurological outcomes at six months?

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