A compendium of critical appraisals in Intensive Care Medicine research and related specialties
A collection of TBL summaries relevant to Peri-operative Medicine
In patients with breast cancer having potentially curative surgery, does a strategy of paravertebral block and propofol anaesthesia, compared to a strategy of opioid and sevoflurane anaesthesia, reduce local or metastatic recurrence?
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In patients undergoing major surgery who are at high risk of complications, does light anaesthesia (BIS 50) compared with deep anaesthesia (BIS 35) improve survival at 1-year?
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In patients with atrial fibrillation (AF) on direct oral anticoagulant (DOAC) medications, does a standard approach to therapy interruption and resumption in the perioperative period result in an acceptable risk for bleeding and thromboembolic events?
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In patients at high risk of respiratory complications after cardiac surgery, does the routine application of high-flow nasal oxygen compared to standard oxygen reduce hospital length of stay?
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In obese patients, does the use of recruitment maneuvers with high PEEP, compared with low PEEP, decrease postoperative pulmonary complications?
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Does titrating positive end-expiratory pressure (PEEP) with the use of an esophageal balloon to estimate pleural pressure improve outcomes compared with an empirical high PEEP –FiO2 strategy in patients with moderate – severe acute respiratory distress syndrome (ARDS)
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In adult ICU patients undergoing tracheal intubation, does bag mask ventilation (BMV) between induction and laryngoscopy reduce the risk of hypoxaemia?
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In high-risk patients undergoing major abdominal surgery, does epidural analgesia compared with no epidural analgesia reduce mortality and morbidity?
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In adult critically ill patients receiving pharmacological thromboprophylaxis, does the use of adjunctive intermittent pneumatic compression devices result in a lower incidence of proximal deep vein thrombosis (DVT)?
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In adult patients undergoing abdominal surgery, with intermediate-to-high-risk of post-operative pulmonary complications, will an individualised perioperative open-lung ventilation strategy (iPROVE), compared with standard protective ventilation, result in fewer post-operative complications during the first 7 days post surgery
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