A collection of TBL summaries relevant to Emergency Medicine

RENOVATE – High-Flow vs NIV

High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients with Acute Respiratory Failure RENOVATE and BRICNet Authors. JAMA 2024. doi: 10.1001/jama.2024.26244 Clinical Question In adult patients with acute respiratory failure does the use of high-flow nasal oxygen compared to noninvasive ventilation reduce the rate of endotracheal intubation or death at 7 days? Background Both high-flow nasal oxygen (HFNO) and noninvasive ventilation […]

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TRAUMOX2 – Early Restrictive vs Liberal Oxygen for Trauma Patients

Early Restrictive vs Liberal Oxygen for Trauma Patients Arleth. JAMA 2024. doi: 10.1001/jama.2024.25786 Clinical Question In adult patients experiencing blunt or penetrating trauma does an early restrictive oxygen strategy compared to a liberal oxygen strategy reduce death and/or major respiratory complications within 30 days? Background ATLS guidelines recommend that all severely injured patients should receive supplemental oxygen in the initial […]

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DanGer Shock – Microaxial Flow Pump in Infarct-Related Cardiogenic Shock

Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock Møller JE et al. 2024. NEJM. DOI: 10.1056/NEJMoa2312572 Clinical Question In adults presenting with STEMI and cardiogenic shock does the use of a microaxial flow pump (Impella CP) compared to standard care reduce death from any cause at day 180? Background Cardiogenic shock is a frequent complication of STEMI and […]

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NICO – Noninvasive Airway Management of Comatose Patients with Acute Poisoning

Effect of Noninvasive Airway Management of Comatose Patients with Acute Poisoning: A Randomized Clinical Trial Freund Y. JAMA. 2023. DOI: 10.1001/jama.2023.24391 Clinical Question In adults with a decreased conscious level from suspected acute poisoning, does withholding intubation versus routine practice reduce in-hospital death, and length of ICU stay and hospital stays? Background The decision to intubate a poisoned patient with […]

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Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury

In patients with trauma and critical bleeding who require activation of a major haemorrhage protocol, does the empiric administration of 3 pools of cryoprecipitate (6g fibrinogen) within 90 minutes of randomisation (and no more than 3 hours after injury) improve survival, compared to standard care?

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