VITAMINS
Does treatment with vitamin C, hydrocortisone, and thiamine lead to a more rapid resolution of septic shock compared with hydrocortisone alone?
Continue reading »Category: Emergency Medicine
A collection of TBL summaries relevant to Emergency Medicine
ESETT
In patients with status epilepticus who have been treated with benzodiazepines, is Levetriracetam, Valproate or Fosphenyoin more likely to lead to an absence of seizures and improved responsiveness at 60 minutes?
Continue reading »PEG-eD
In low and moderate risk patients presenting to the Emergency Department with symptoms suggestive of pulmonary embolism (PE), can a higher d-dimer threshold be used to safely exclude pulmonary embolism without the need for imaging?
Continue reading »LEAP2
Is 5-day oral lefamulin non-inferior to 7-day oral moxifloxacin in the management of community-acquired bacterial pneumonia?
Continue reading »ANTHARTIC
Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest Francois et al. N Engl J Med 2019;381:1831-42. DOI: 10.1056/NEJMoa1812379 Clinical Question In post out-of-hospital cardiac arrest patients treated with targeted temperature management, does the use of empirical antibiotics prevent early ventilator-associated pneumonia? Background Rates of survival to hospital discharge and good neurological outcomes post out-of-hospital cardiac arrest (OOHCA) remain poor Despite […]
Continue reading »CRASH-3
Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH – 3): a randomised, placebo-controlled trial The CRASH-3 trial collaborators. The Lancet, 2019; doi.org/10.1016/S1040-6736(19)32233-0 Clinical Question In patients with traumatic brain injury (TBI), does the administration of tranexamic acid (TXA) under 3 hours from injury, compared with placebo, reduce […]
Continue reading »HYPERION
In patients with coma following cardiac arrest with a non-shockable rhythm, does moderate hypothermia vs. normothermia, improve neurological outcome?
Continue reading »AVERT Shock
In trauma patients with hemorrhagic shock, does the use of low-dose arginine vasopressin compared to placebo reduce the volume of blood products transfused?
Continue reading »TRACT Transfusion Volume
Transfusion Volume for Children with Severe Anaemia in Africa K.Maitland. New England Journal of Medicine August 1st 2019; 381:5; 420-431. doi: 10.1056/NEJMoa1900100 Clinical Question In African children presenting to hospital with severe anaemia, is a blood transfusion volume of 30 ml/kg superior to 20 ml/kg in reducing 28 day mortality? Background Severe anaemia is a major cause of death and […]
Continue reading »TRACT Tranfusion Timing
In children hospitalised with uncomplicated severe anaemia, is an immediate blood transfusion strategy superior to delayed transfusion in reducing 28-day mortality?
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