HALT-IT
In patients with gastrointestinal (GI) bleeding does high dose tranexamic acid (TXA) when compared to a placebo reduce mortality from GI bleeding?
Continue reading »Category: Emergency Medicine
A collection of TBL summaries relevant to Emergency Medicine
DIRECT-MT
In patients with acute anterior ischaemic stroke, is endovascular thrombectomy alone, compared with endovascular thrombectomy preceded by intravenous alteplase, noninferior with respect to modified Rankin score at 90 days?
Continue reading »Boulware
In people who have high-risk or moderate-risk exposure to someone with confirmed COVID-19 infection, does taking hydroxychloroquine following the exposure compared to placebo reduce the incidence of a new illness compatible with COVID-19?
Continue reading »ACTT-1
In hospitalised adult patients with evidence of lower respiratory tract infection due to COVID-19, is remdesivir superior to placebo in shortening the time to recovery?
Continue reading »LOTUS China
In patients infected with SARS-CoV-2, what is the efficacy and safety of oral lopinavir–ritonavir?
Continue reading »FABLED
In patients with severe sepsis what is the sensitivity of blood cultures taken after the initiation of antimicrobial therapy?
Continue reading »CURASMUR
In patients requiring emergency out-of-hospital endotracheal intubation, is rocuronium non-inferior to suxamethonium in providing a successful first pass attempt?
Continue reading »VITAMINS
Does treatment with vitamin C, hydrocortisone, and thiamine lead to a more rapid resolution of septic shock compared with hydrocortisone alone?
Continue reading »ESETT
In patients with status epilepticus who have been treated with benzodiazepines, is Levetriracetam, Valproate or Fosphenyoin more likely to lead to an absence of seizures and improved responsiveness at 60 minutes?
Continue reading »PEG-eD
In low and moderate risk patients presenting to the Emergency Department with symptoms suggestive of pulmonary embolism (PE), can a higher d-dimer threshold be used to safely exclude pulmonary embolism without the need for imaging?
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