A compendium of critical appraisals in Intensive Care Medicine research and related specialties
A collection of TBL summaries relevant to Emergency Medicine
In trauma patients with exsanguinating haemorrhage, does the use of the REBOA (resuscitative endovascular balloon occlusion of the aorta) device with standard care in the emergency department, compared with standard care alone, impact 90-day-mortality?
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In patients with trauma and critical bleeding who require activation of a major haemorrhage protocol, does the empiric administration of 3 pools of cryoprecipitate (6g fibrinogen) within 90 minutes of randomisation (and no more than 3 hours after injury) improve survival, compared to standard care?
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Extracorporeal Life Support in Infarct-Related Cardiogenic Shock Thiele H. NEJM 2023; Online ahead of print. doi:10.1056/NEJMoa2307227 Clinical Question In patients presenting with acute myocardial infarction complicated by cardiogenic shock undergoing revascularisation, does the early unselected application of extracorporeal life support reduce mortality from any cause at day 30? Background The use of venoarterial extracorporeal membrane oxygenation (VA ECMO), which is […]
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In patients with non-ST elevation out-of-hospital cardiac arrest, does expedited delivery of patients to a cardiac arrest centre, compared with delivery to the geographically closest hospital, improve all-cause mortality at 30 days?
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In critically ill adults undergoing tracheal intubation, does the use of a videolaryngoscope (VL) compared to a direct laryngoscope (DL) improve the first-pass success rate?
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In adult patients with major trauma, who are at risk for trauma-induced coagulopathy does early administration of 1g of tranexamic acid (TXA) followed by an infusion of 1g over 8 hours, compared with placebo, increase survival with a favourable functional outcome at 6 months?
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In patients with refractory out-of-hospital cardiac arrest (OHCA) and an initial ventricular arrhythmia, does extracorporeal cardiopulmonary resuscitation (ECPR), as compared with conventional CPR (CCPR), improve survival with a favourable neurologic outcome
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In patients with sepsis-induced hypotension does a restrictive fluid strategy (with early vasopressor usage) compared to a liberal fluid strategy result in lower mortality before discharge by day 90?
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In patients with refractory VF, does Double Sequential External Defibrillation or Vector-change Defibrillation improve survival to hospital discharge?
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Diuretics Versus Volume Expansion in the Initial Management of Acute Intermediate HighâRisk Pulmonary Embolism Ferrari E. Lung (2022); DOI:10.1007/s00408-022-00530-5 Clinical Question In adult patients with acute pulmonary embolism and right heart strain does a strategy of volume expansion or early diuretic therapy result in a more rapid resolution of troponin levels? Background Acute pulmonary embolism (PE) is a common cause […]
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