Category: Emergency Medicine

A collection of TBL summaries relevant to Emergency Medicine

ANTHARTIC

Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest Francois et al. N Engl J Med 2019;381:1831-42. DOI: 10.1056/NEJMoa1812379 Clinical Question In post out-of-hospital cardiac arrest patients treated with targeted temperature management, does the use of empirical antibiotics prevent early ventilator-associated pneumonia? Background Rates of survival to hospital discharge and good neurological outcomes post out-of-hospital cardiac arrest (OOHCA) remain poor Despite […]

CRASH-3

9 November 2019 George Walker Emergency Medicine, Summaries Leave a comment

Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH – 3): a randomised, placebo-controlled trial The CRASH-3 trial collaborators. The Lancet, 2019; doi.org/10.1016/S1040-6736(19)32233-0 Clinical Question In patients with traumatic brain injury (TBI), does the administration of tranexamic acid (TXA) under 3 hours from injury, compared with placebo, reduce […]

HYPERION

11 October 2019 Segun Olusanya Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

In patients with coma following cardiac arrest with a non-shockable rhythm, does moderate hypothermia vs. normothermia, improve neurological outcome?

AVERT Shock

6 September 2019 David Slessor Emergency Medicine, Summaries One comment

In trauma patients with hemorrhagic shock, does the use of low-dose arginine vasopressin compared to placebo reduce the volume of blood products transfused?

TRACT Transfusion Volume

23 August 2019 Fraser Magee Emergency Medicine, Intensive Care Medicine Leave a comment

Transfusion Volume for Children with Severe Anaemia in Africa K.Maitland. New England Journal of Medicine August 1st 2019; 381:5; 420-431. doi: 10.1056/NEJMoa1900100 Clinical Question In African children presenting to hospital with severe anaemia, is a blood transfusion volume of 30 ml/kg superior to 20 ml/kg in reducing 28 day mortality? Background Severe anaemia is a major cause of death and […]

TRACT Tranfusion Timing

16 August 2019 Fraser Magee Emergency Medicine Leave a comment

In children hospitalised with uncomplicated severe anaemia, is an immediate blood transfusion strategy superior to delayed transfusion in reducing 28-day mortality?

IVC Filters

12 July 2019 Adrian Wong Emergency Medicine, Intensive Care Medicine Leave a comment

In severely injured trauma patients, where anticoagulation is contraindicated, does the use of prophylactic inferior vena cava filters reduce the incidence of pulmonary embolism (PE)?

OPTALYSE PE

5 July 2019 David Slessor Emergency Medicine, Summaries Leave a comment

In patients with intermediate risk PE, do low doses of tPA and short durations of ultrasound facilitated catheter directed thrombolysis, result in a reduction in RV:LV diameter at 48 hours?

SCARLET

14 June 2019 George Walker Emergency Medicine, Intensive Care Medicine Leave a comment

In adult patients with sepsis-associated coagulopathy does the administration of human recombinant thrombomodulin (rhsTM) compared to placebo reduce 28 day mortality?

EXTEND

31 May 2019 David Slessor Emergency Medicine, Summaries Leave a comment

In patients with acute ischaemic stroke, with salvageable brain tissue, does alteplase compared with placebo, administered between 4.5 – 9 hours post stroke onset, improve functional outcome at 90 days?

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