Category: Intensive Care Medicine

A collection of TBL summaries relevant to Intensive Care Medicine

ANTHARTIC

Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest Francois et al. N Engl J Med 2019;381:1831-42. DOI: 10.1056/NEJMoa1812379 Clinical Question In post out-of-hospital cardiac arrest patients treated with targeted temperature management, does the use of empirical antibiotics prevent early ventilator-associated pneumonia? Background Rates of survival to hospital discharge and good neurological outcomes post out-of-hospital cardiac arrest (OOHCA) remain poor Despite […]

COLCOT

22 November 2019 David Slessor Intensive Care Medicine Leave a comment

In patients post myocardial infarction, does low dose colchicine compared with placebo, reduce ischaemic cardiovascular events?

ICU-ROX

1 November 2019 Celia Bradford Intensive Care Medicine One comment

In mechanically ventilated ICU patients does a conservative use of oxygen therapy compared to usual oxygen therapy affect the number of ventilator-free-days?

Vitamin C Sepsis

25 October 2019 Segun Olusanya Intensive Care Medicine, Summaries Leave a comment

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial Fowler AA. JAMA; 2019;322(13):1261-1270 Clinical Question In patients with sepsis and acute respiratory distress syndrome, can intravenous administration of vitamin C, compared to placebo, reduce organ failure scores and biomarkers of inflammation and vascular injury? […]

Subira

20 October 2019 Duncan Chambler Intensive Care Medicine Leave a comment

In patients weaning from mechanical ventilation, does a spontaneous breathing trial (SBT) with pressure support (PS) for 30 minutes vs a SBT with T-piece for 2 hours differ in the rate of successful liberation from mechanical ventilation (MV)?

HYPERION

11 October 2019 Segun Olusanya Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

In patients with coma following cardiac arrest with a non-shockable rhythm, does moderate hypothermia vs. normothermia, improve neurological outcome?

Garrouste-Orgeas

4 October 2019 David Slessor Intensive Care Medicine Leave a comment

In intensive care patients, does an ICU diary compared to no ICU diary, reduce post-traumatic stress disorder symptoms at 3 months?

SoM

27 September 2019 Duncan Chambler Intensive Care Medicine Leave a comment

Contact precautions in single-bed or multiple-bed rooms for patients with extended-spectrum Beta-lactamase-producing enterobacteriaceae in Dutch hospitals Kluytmans-van den Bergh. Lancet Infectious Diseases 2019; Published online 23rd August 2019. doi: 10.1016/S1473-3099(19)30262-2. Clinical Question In non-ICU, non-haematology patients that have been identified as carriers of extended-spectrum beta-lactamase-producing enterobacteriaceae (ESBLs), is a strategy of contact precautions in a multiple-bed room compared to contact […]

PHARLAP

20 September 2019 James Walter Intensive Care Medicine Leave a comment

Does an open lung ventilation strategy which includes maximal recruitment maneuvers (RMs) and positive end-expiratory pressure (PEEP) titration improve outcomes compared to traditional lung-protective ventilation in patients with moderate – severe acute respiratory distress syndrome (ARDS)?

PAUSE

13 September 2019 Celia Bradford Intensive Care Medicine, Peri-operative Medicine Leave a comment

In patients with atrial fibrillation (AF) on direct oral anticoagulant (DOAC) medications, does a standard approach to therapy interruption and resumption in the perioperative period result in an acceptable risk for bleeding and thromboembolic events?

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