A collection of TBL summaries relevant to Intensive Care Medicine

ANTHARTIC

Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest Francois et al. N Engl J Med 2019;381:1831-42. DOI: 10.1056/NEJMoa1812379 Clinical Question In post out-of-hospital cardiac arrest patients treated with targeted temperature management, does the use of empirical antibiotics prevent early ventilator-associated pneumonia? Background Rates of survival to hospital discharge and good neurological outcomes post out-of-hospital cardiac arrest (OOHCA) remain poor Despite […]

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Vitamin C Sepsis

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial Fowler AA. JAMA; 2019;322(13):1261-1270 Clinical Question In patients with sepsis and acute respiratory distress syndrome, can intravenous administration of vitamin C, compared to placebo, reduce organ failure scores and biomarkers of inflammation and vascular injury? […]

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