Tag: Transfusion

SAHARA – Liberal vs Restrictive Transfusion Targets in SAH

18 December 2024 Celia Bradford Intensive Care Medicine Leave a comment

Liberal versus Restrictive Transfusion in Aneurysmal Subarachnoid Haemorrhage English S. NEJM 2024 DOI:10.1056/NEJMoa2410962 Clinical Question In patients following acute aneurysmal subarachnoid haemorrhage, does a liberal strategy of blood transfusion compared with a restrictive strategy of blood transfusion reduce unfavourable neurological outcome? SubArachnoid Haemorrhage Red-cell transfusion And Outcome (SAHaRA) Background Anaemia is common following aneurysmal subarachnoid haemorrhage with an incidence of approximately 50% during the […]

TRAIN – Transfusion Strategies in Acute Brain Injured Patients

26 October 2024 andrew.achilleos@nhs.net Intensive Care Medicine, Summaries Leave a comment

Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury @fabio_taccone. JAMA. 2024. PMID: 39382241 Clinical Question In patients with acute brain injury, does a liberal, compared to a restrictive strategy of blood transfusion, improve neurological outcomes at 180 days? Background The TRICC study, published over 20 years go, led to the widespread adoption of restrictive thresholds for blood […]

HEMOTION – transfusion thresholds in TBI

24 June 2024 Celia Bradford Intensive Care Medicine One comment

Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury Turgeon AF. NEJM June 13 2024; doi:10.1056/NEJMoa240360 Clinical Question In adult patients with moderate or severe traumatic brain injury, does a liberal transfusion strategy (transfusion if haemoglobin <10g/dl) compared to a restrictive strategy (transfusion if haemoglobin <7g/dl) reduce the rate of an unfavourable Glasgow Outcome Scale – Extended, at […]

Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury

18 October 2023 Celia Bradford Emergency Medicine, Intensive Care Medicine, Peri-operative Medicine, Summaries Leave a comment

In patients with trauma and critical bleeding who require activation of a major haemorrhage protocol, does the empiric administration of 3 pools of cryoprecipitate (6g fibrinogen) within 90 minutes of randomisation (and no more than 3 hours after injury) improve survival, compared to standard care?

Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia

28 July 2023 George Walker Evidence-based Medicine, Intensive Care Medicine Leave a comment

In haematology or ICU patients with platelet counts between 10,000 and 50,000 per mm3, is receiving no prophylactic platelets non inferior compared to the administration of 1u platelets in order to reduce the risk of catheter-related bleeding?

PATCH

19 June 2023 Celia Bradford Emergency Medicine, Intensive Care Medicine Leave a comment

In adult patients with major trauma, who are at risk for trauma-induced coagulopathy does early administration of 1g of tranexamic acid (TXA) followed by an infusion of 1g over 8 hours, compared with placebo, increase survival with a favourable functional outcome at 6 months?

RePHILL

1 April 2022 Celia Bradford Emergency Medicine, Intensive Care Medicine Leave a comment

In patients with trauma-related haemorrhagic shock does prehospital administration of packed red cells and lyophilised plasma (Lyo-Plas) compared with normal saline reduce the composite outcome of mortality and failure to reach lactate clearance?

FEISTY

9 April 2021 George Walker Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

In adult trauma patients with major haemorrhage and hypofibrinogenaemia does the use fibrinogen concentrate (FC) compared to cryoprecipitate (cryo) result in a shorter time to administration?

REALITY

6 March 2021 Celia Bradford Intensive Care Medicine Leave a comment

In patients with acute myocardial infarction and anaemia is a restrictive, compared with a liberal transfusion strategy, non-inferior with respect to major adverse cardiovascular outcomes at 30 days?

Timing of Endoscopy for Acute Upper Gastrointestinal Bleeding

20 August 2020 George Walker Emergency Medicine Leave a comment

In patients with acute upper GI (UGI) bleeding and a Glasgow-Blatchford score ≥ 12, does endoscopy performed within 6 hours of gastroenterological consultation, compared with endoscopy performed within 6 – 24 hours have a lower 30 day mortality?

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