A compendium of critical appraisals in Intensive Care Medicine research and related specialties
In patients with cardiogenic shock receiving venoarterial extracorporeal membrane oxygenation(VA-ECMO), does early use of moderate hypothermia (33-34°C) compared with strict normothermia (36-37 °C) improve 30 day mortality?
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In patients who are unconscious following out-of-hospital cardiac arrest, does targeted hypothermia compared with targeted normothermia, impact all-cause mortality?
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In patients with coma following cardiac arrest with a non-shockable rhythm, does moderate hypothermia vs. normothermia, improve neurological outcome?
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In patients that survive with a good neurological outcome following out-of-hospital cardiac arrest, does 48 hours vs. 24 hours of therapeutic hypothermia, improve memory, attention & executive function at 6 months?
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In patients with severe blunt traumatic brain injury (TBI) does early and sustained cooling compared with standard care improve neurological outcomes at 6 months?
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In septic and mechanically ventilated patients aged 50 or over, does 24 hours of induced hypothermia followed by 48 hours of normothermia improve 30-day mortality compared to routine care?
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In adults with out of hospital cardiac arrest (OOHCA) due to a presumed cardiac cause, who are post ‘return of spontaneous circulation’ (ROSC), does cooling to 33°C for 48 hours, compared with 24 hours, improve improved neurological outcomes at 6 months?
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In patients with traumatic brain injury (TBI), does hypothermia (32-35°C) and standard care compared to standard care alone reduce death and major disability at 6 months after injury?
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Does the regular administration of paracetamol to critically ill patients with fever and known or suspected infection, affect the number of ICU-free days?
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In children suffering an out-of-hospital cardiac arrest, does hypothermia compared to normothermia increase survival with a good neurobehavioural outcome?
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