Year: 2025

BICARICU-2: NaHCO3 for Metabolic Acidemia

Intensive Care Medicine Leave a comment

Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury Jung et al. JAMA 2025. doi: 10.1001/jama.2025.20231 Clinical Question In patients with severe metabolic acidosis (pH ≤7.20) and moderate to severe AKI  does the administration of sodium bicarbonate (NaHCO3) compared to placebo reduce 90-day mortality? Background Multiple cardiac, respiratory, renal and neurological pathophysiological consequences of severe academia have been reported […]

Continue reading »

REMAP CAP: Corticosteroids

Intensive Care Medicine Leave a comment

Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia: The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial Angus. ICM 2025; doi: https://doi.org/10.1007/s00134-025-07861-w Clinical Question In adult patients with severe community acquired pneumonia (CAP) requiring ICU admission, does a 7-day course of intravenous hydrocortisone reduce 90-day mortality? Background Community-acquired pneumonia (CAP) remains a leading cause of ICU admissions and mortality […]

Continue reading »

Target Protein – Augmented Enteral Protein During Critical Illness

Intensive Care Medicine Leave a comment

Augmented Enteral Protein During Critical Illness MJ Summers. JAMA 2025; doi: 10.1001/jama.2025.9110 Clinical Question In critically ill patients receiving enteral nutrition does the augmentation of protein delivery compared to standard care result in an increased number of days free of the index hospital and alive at day 90? Background Critical illness weakness is a common complication within the ICU population […]

Continue reading »

Shared Decision Making in Resuscitation Decisions

Intensive Care Medicine, Peri-operative Medicine Leave a comment

A Randomized Trial of Shared Decision-Making in Code Status Discussions Becker. NEJM Evidence 2025; doi:10.1056/EVIDoa2400422 Clinical Question In hospitalized adults requiring code status discussions, does a shared decision-making approach (including a checklist and decision aid) compared to usual care increase the proportion of patients choosing a DNR status? Background In-hospital cardiac arrest outcomes are poor (<20% survival; ~40% with neurologic […]

Continue reading »

UK-ROX Trial

Intensive Care Medicine Leave a comment

Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients Martin. JAMA June 12 2025; doi:10.1001/jama.2025.9663 Clinical Question In mechanically ventilated adult patients in the ICU, does a strategy of conservative oxygen therapy, targeting a SpO2 of 90% (Range 88-92%) compared with usual care, reduce mortality at 90 days? Background In the United Kingdom, around 184,000 adults are admitted to […]

Continue reading »
1 2