A compendium of critical appraisals in Intensive Care Medicine research and related specialties
A category to collect all the summaries, so that they can be used in menus and widgets. Please don’t expand this – “Specialties” and “Special Topics” have been created as a custom category sets for the clinical topics.
In children hospitalised with uncomplicated severe anaemia, is an immediate blood transfusion strategy superior to delayed transfusion in reducing 28-day mortality?
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In adults with decompensated heart failure who are at high-risk of diuretic resistance, does furosemide administered by infusion compared to intermittent bolus increase the incidence of freedom from congestion at 72 hours?
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In obese patients, does the use of recruitment maneuvers with high PEEP, compared with low PEEP, decrease postoperative pulmonary complications?
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In adult critically ill patients with hypoxemic respiratory failure necessitating intubation, does high-flow nasal cannula (HFNC) compared to bag-valve-mask (BVM) for both pre-oxygenation and oxygenation during intubation reduce desaturation?
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In patients with cirrhosis and acute variceal bleeding, does early transjugular intrahepatic portosystemic shunt (TIPS) compared to standard care increase transplant-free survival?
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In severely injured trauma patients, where anticoagulation is contraindicated, does the use of prophylactic inferior vena cava filters reduce the incidence of pulmonary embolism (PE)?
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In patients with intermediate risk PE, do low doses of tPA and short durations of ultrasound facilitated catheter directed thrombolysis, result in a reduction in RV:LV diameter at 48 hours?
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In patients with moderate to severe ARDS, does a strategy of early neuromuscular blockade with heavy sedation, as opposed to usual care with lighter sedation targets, result in a lower 90 day mortality?
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In critically ill adults, does haloperidol 1 mg or haloperidol 2 mg given three times a day compared to placebo reduce mortality?
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In adult patients with sepsis-associated coagulopathy does the administration of human recombinant thrombomodulin (rhsTM) compared to placebo reduce 28 day mortality?
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