Tag: Microbiology

ADAPT-Sepsis: PCT or CRP Guided Antibiotic Duration

24 January 2025 Hrishee Vaidya Intensive Care Medicine, Summaries Leave a comment

ADAPT-Sepsis: PCT or CRP-guided Antibiotic Duration for Patients with suspected Sepsis Dark et al. JAMA Dec 9 2024. doi:10.1001/jama.2024.26458 Clinical Question For critically ill adults with suspected sepsis, does a procalcitonin (PCT) guided or C-reactive protein (CRP) guided antibiotic discontinuation prompt, compared with usual care, reduce the total duration of antibiotics without increasing all-cause 28-day mortality? Background Shorter antibiotic durations […]

REVISE – Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation

12 July 2024 Celia Bradford Intensive Care Medicine Leave a comment

Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation (REVISE) D. Cook. NEJM 2024. DOI: 10.1056/NEJMoa2404245 Clinical Question In mechanically ventilated adults, does stress ulcer prophylaxis with intravenous pantoprazole (40 mg daily), compared with placebo (0.9% saline), reduce the occurrence of clinically important upper gastrointestinal bleeding at 90 days? Background Critical illness is associated with an increased risk of gastrointestinal (GI) stress […]

ARiE Trial – Rifaximin for encephalopathy

1 March 2024 Aniket Nadkarni Intensive Care Medicine, Summaries Leave a comment

In critically ill adults with overt acute hepatic encephalopathy (HE) admitted to ICU, does the addition of rifaximin to broad spectrum antimicrobials affect time to resolution of HE?

PROPHY-VAP: Ceftriaxone to prevent early ventilator-associated pneumonia

8 February 2024 andrew.achilleos@nhs.net Intensive Care Medicine, Summaries Leave a comment

In patients with severe brain injury who require mechanical ventilation, does an early, single dose of ceftriaxone compared with placebo reduce the incidence of early VAP?

CandiSep

12 August 2022 George Walker Intensive Care Medicine, Summaries Leave a comment

In septic adults at high risk for invasive candida infection (ICI) does the use (1,3)-β-D-glucan (BDG) guided antifungal strategy, compared with standard treatment, reduce 28-day mortality compared to standard care?

RECOVERY: COVID-19 Kaletra

21 October 2020 Celia Bradford Intensive Care Medicine Leave a comment

In patients admitted to hospital with COVID-19, does Lopinavir-ritonavir therapy (Kaletra) compared to usual care, reduce 28-day mortality?

ACTT-1

25 May 2020 Fraser Magee Emergency Medicine, Intensive Care Medicine One comment

In hospitalised adult patients with evidence of lower respiratory tract infection due to COVID-19, is remdesivir superior to placebo in shortening the time to recovery?

Pandemic Triage

22 March 2020 Fraser Magee Intensive Care Medicine One comment

A multicentre evaluation of two intensive care unit triage protocols for use in an influenza pandemic Winston K Cheung. Medical Journal of Australia; August 2012 [3]:178-181. doi:10.5694/mja11.10926] Clinical Question In the event of a viral pandemic, what effect does the use of a triage protocol (specifically the NSW ICU triage protocol) have in increasing ICU bed availability, both in admission […]