INSTINCT
In patients with necrotising soft tissue infection (NSTI), does the use of intravenous immunoglobulin (IVIG) compared to placebo improve patient reported physical outcomes?
Continue reading »Tag: Microbiology
EMPIRICUS
In non-neutropenic critically ill patients with sepsis, multiple Candida colonisation, and multiple organ failure exposed to broad-spectrum antibacterials, does empirical micafungin therapy compared to placebo increase invasive fungal infection-free survival at day 28?
Continue reading »Talan
In patients with drained cutaneous abscesses does trimethoprim-sulfamethoxazole compared with placebo increase clinical cure rates?
Continue reading »Uranga
In hospitalised patients with community-acquired pneumonia (CAP), is five days of antibiotic therapy non-inferior to standard practice with respect to clinical improvement?
Continue reading »BLISS
In adult ICU patients with severe sepsis does the use of continuous infusion (CI) of beta-lactam antibiotics compared to intermittent bolus (IB) improve clinical outcomes?
Continue reading »APPAC
In patients presenting with acute uncomplicated appendicitis, is antibiotic therapy non-inferior to appendicectomy surgery?
Continue reading »PRORATA
In adult patients with suspected bacterial infections, does procalcitonin-guided antibiotic care compared to usual care reduce patient exposure to antibiotics without increasing mortality?
Continue reading »3Sites
In intensive care patients who require a central venous catheter (CVC), does the choice of insertion site affect the complication rates?
Continue reading »BLING2
In adult ICU patients on beta-lactam antibiotics, does continuous infusion compared to intermittent bolus increase survival?
Continue reading »STOP-IT
In patients with intraabdominal sepsis and who have received adequate source control, does a fixed short course of antibiotics result in similar treatment success compared to a longer duration of antibiotic therapy?
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