CAPE COD
In patients with severe community acquired pneumonia (CAP) does the use of hydrocortisone compared to a placebo reduce 28-day mortality?
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COAST
In hypoxic African children (oxygen saturations of between 80 and 91%) with pneumonia, does oxygen therapy reduce mortality when compared with a permissive hypoxia (no oxygen) strategy?
In severely hypoxic children (oxygen saturations less than 80%), does high-flow nasal therapy reduce mortality when compared with low-flow oxygen therapy?