A compendium of critical appraisals in Intensive Care Medicine research and related specialties
Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections BALANCE Investigators. NEJM 2024; DOI: 10.1056/NEJMoa2404991 Clinical Question In hospitalised patients with bloodstream infections (BSI), is antibiotic treatment for 7 days, compared to treatment for 14 days, non-inferior with respect to mortality at 90 days? Background BSI are common and a leading cause of mortality and morbidity, accounting […]
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In critically ill adult patients with presumed sepsis, does the administration of β-lactam antibiotics via a continuous infusion compared to an intermittent infusion reduce 90-day mortality?
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Is 5-day oral lefamulin non-inferior to 7-day oral moxifloxacin in the management of community-acquired bacterial pneumonia?
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In hospitalised patients with community-acquired pneumonia (CAP), is five days of antibiotic therapy non-inferior to standard practice with respect to clinical improvement?
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