SHINE
In neonates undergoing elective endotracheal intubation, does nasal high-flow therapy compared with standard care, improve 1st pass success without physiological instability?
Continue reading »Tag: Paediatrics
McCardle
Treatment of Multisystem Inflammatory Syndrome in Children McArdle. NEJM 2021; 385: 35-45.DOI: 10.1056/NEJMoa2102968 Clinical Question In children with multisystem inflammatory syndrome, what affect do different treatments have on the composite of inotropic support or mechanical ventilation by day 2 or death, and disease severity by day 2? Background Multisystem inflammatory syndrome in children (MIS-C) is a new, rare but serious […]
Continue reading »TRACT Transfusion Volume
Transfusion Volume for Children with Severe Anaemia in Africa K.Maitland. New England Journal of Medicine August 1st 2019; 381:5; 420-431. doi: 10.1056/NEJMoa1900100 Clinical Question In African children presenting to hospital with severe anaemia, is a blood transfusion volume of 30 ml/kg superior to 20 ml/kg in reducing 28 day mortality? Background Severe anaemia is a major cause of death and […]
Continue reading »TRACT Tranfusion Timing
In children hospitalised with uncomplicated severe anaemia, is an immediate blood transfusion strategy superior to delayed transfusion in reducing 28-day mortality?
Continue reading »FiSh
In children with septic shock, does a restricted fluid bolus volume, compared with a standard fluid bolus volume, improve outcomes?
Continue reading »Franklin
In infants (<12 months) with bronchiolitis and hypoxaemia (saturations <92%) in the emergency department or general paediatric ward, does early treatment with high flow therapy versus standard oxygen therapy result in fewer infants having treatment failure that leads to escalation of care?
Continue reading »Ventura
In paediatric patients with septic shock, does adrenaline compared with dopamine reduce 28 day mortality?
Continue reading »THAPCA-OH
In children suffering an out-of-hospital cardiac arrest, does hypothermia compared to normothermia increase survival with a good neurobehavioural outcome?
Continue reading »FEAST
In paediatric patients with severe febrile illnesses, in a resource limited setting, do fluid boluses with albumin vs. saline vs. no fluid boluses affect mortality?
Continue reading »RESTORE
Does a nurse-implemented, goal-directed sedation protocol result in fewer ventilator days in children with acute respiratory failure?
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