In hospitalised patients with SARS-CoV-2 infection does dexamethasone in additional to usual care, compared to usual care alone, reduce 28-day mortality?Continue reading »
In adult patients with COVID-19, does combined interferon beta-1b, lopinavir-ritonavir, and ribavirin, compared with lopinavir-ritonavir alone, reduce the time to a negative swab result?Continue reading »
TBL at Wessex Intensive Care Society meeting 2019 #WICS19 It’s a pleasure to be speaking at WICS 2019. I will be producing notes here to support my talk later today. This will include a narrative of my slides, a little more depth of content and links to all the trials. In short, here are my 6 key statements: Video-laryngoscopy is […]Continue reading »
This editorial blog has been written to complement the short presentation delivered by Duncan Chambler at the British Association of Indian Anaesthetists (BAOIA) 2018 conference in Newcastle.Continue reading »
In this Editorial, Professor Imelda Galvin from Queen’s University in Canada takes us through the details of Power, how it relates to trial sample size, and why it matters.Continue reading »
In patients with septic shock, do corticosteroids compared to placebo reduce mortality?
This is an editorial blog post in anticipation of the ADRENAL trial results to be presented at #CCR18.
It’s been another big year for research in ICM, EM and Peri-operative Care. What do the TBL editors think are the best trials of 2017?Continue reading »
P-values – interpreting the evidence seriesContinue reading »
Rather than reinvent the wheel, we are delighted to include a link to the RCEM Critical Appraisal Dictionary. The RCEM learning site provides excellent open access educational resources, including critical care appraisal modulesContinue reading »
In statistical hypothesis testing, a type I error is the incorrect rejection of a true null hypothesis (a “false positive”), while a type II error is incorrectly retaining a false null hypothesis (a “false negative”). The more you try and avoid a Type I error (false positive), the more likely a Type II error (false negative) may happen. Researchers have found that an alpha level of 5% is a good balance between these two issuesContinue reading »