Tag: Perioperative Care

BigPAK-2 – preventive care strategy to reduce acute kidney injury after major surgery

A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial Zarbock. The Lancet 2025. doi: 10.1016/S0140-6736(25)01717-9 Clinical Question In patients at high risk of AKI undergoing major surgery, does a preventative care strategy based on KDIGO guidelines, compared to standard care lead to a reduction in moderate/severe AKI within […]

Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery

28 November 2025 Jake Reeve Peri-operative Medicine Leave a comment

Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery: The IMPROVE-multi Randomized Clinical Trial B Saugel. JAMA 2025; doi: 10.1001/jama.2025.17235 Clinical Question In patients undergoing major intra-abdominal surgery, does an individualised blood pressure target, compared to standard care, improve rates of acute kidney injury, acute myocardial infarction, non-fatal cardiac arrest or death within the first 7 days? Background […]

PROTECTION – Amino Acids for Kidney Protection

7 July 2024 Celia Bradford Intensive Care Medicine, Peri-operative Medicine Leave a comment

In adult patients scheduled for cardiac surgery with cardiopulmonary bypass does infusion of a balanced solution of amino acids, commencing at the time of surgery, compared with balanced crystalloid alone (Ringer’s Lactate) reduce the incidence of acute kidney injury (AKI)?

PALACS

31 December 2021 Celia Bradford Intensive Care Medicine, Peri-operative Medicine Leave a comment

Posterior left pericardiotomy for the prevention of atrial fibrillation after cardiac surgery Mario Gaudino, The Lancet Dec 4 2021; 398: 2075–83 https://doi.org/10.1016/S0140-6736(21)02490-9 Clinical Question In selected patients undergoing cardiac surgery, does posterior left pericardiotomy compared with usual care, reduce the incidence of postoperative atrial fibrillation? Background Atrial fibrillation is common following cardiac surgery with approximately one-third of patients developing […]

Dex-CSDH

26 January 2021 Celia Bradford Intensive Care Medicine, Peri-operative Medicine Leave a comment

In patients with chronic subdural haemorrhage, what effect does dexamethasone compared with placebo have on neurological outcome at 6 months?

PAUSE

13 September 2019 Celia Bradford Intensive Care Medicine, Peri-operative Medicine Leave a comment

In patients with atrial fibrillation (AF) on direct oral anticoagulant (DOAC) medications, does a standard approach to therapy interruption and resumption in the perioperative period result in an acceptable risk for bleeding and thromboembolic events?

IMPACT

19 October 2018 Duncan Chambler Peri-operative Medicine Leave a comment

In adult patients at risk of nausea and vomiting during surgery, do multiple antiemetic interventions compared to single antiemetic interventions or no intervention reduce nausea and vomiting?

TRICS-III 6 month follow up

5 October 2018 Steve Mathieu Intensive Care Medicine, Peri-operative Medicine Leave a comment

In patients undergoing cardiac surgery, who have a moderate-to-high risk of death, does a restrictive transfusion strategy compared with a liberal strategy impact on a composite outcome of death, myocardial infarction, stroke and acute kidney injury requiring dialysis at 6 months after surgery?

RELIEF

18 May 2018 Steve Mathieu Intensive Care Medicine, Peri-operative Medicine, Summaries 5 comments

In adult patients undergoing major elective abdominal surgery, does a restrictive fluid regimen compared with a liberal fluid regimen reduce complications and improved disability-free survival?

FEDORA

27 April 2018 Duncan Chambler Peri-operative Medicine Leave a comment

In peri-operative patients at low to moderate risk of post-operative complications, does goal-directed haemodynamic therapy using oesophageal doppler monitoring compared to standard care, reduce the incidence of post-operative complications within 180 days?

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