Tag: Anticoagulation

HALT-IT

26 June 2020 George Walker Emergency Medicine, Summaries One comment

In patients with gastrointestinal (GI) bleeding does high dose tranexamic acid (TXA) when compared to a placebo reduce mortality from GI bleeding?

CRASH-3

9 November 2019 George Walker Emergency Medicine, Summaries One comment

Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH – 3): a randomised, placebo-controlled trial The CRASH-3 trial collaborators. The Lancet, 2019; doi.org/10.1016/S1040-6736(19)32233-0 Clinical Question In patients with traumatic brain injury (TBI), does the administration of tranexamic acid (TXA) under 3 hours from injury, compared with placebo, reduce […]

PAUSE

13 September 2019 Celia Bradford Intensive Care Medicine, Peri-operative Medicine Leave a comment

In patients with atrial fibrillation (AF) on direct oral anticoagulant (DOAC) medications, does a standard approach to therapy interruption and resumption in the perioperative period result in an acceptable risk for bleeding and thromboembolic events?

EXTEND IA TNK

8 June 2018 Fraser Magee Emergency Medicine, Intensive Care Medicine Leave a comment

In patients with anterior circulation strokes undergoing endovascular thrombectomy, is IV thrombolysis within 4.5 hours of stroke onset with tenecteplase, non-inferior to alteplase, at establishing reperfusion?

CURE

12 January 2018 David Slessor Emergency Medicine, Summaries 3 comments

In patients with acute coronary syndromes without ST elevation, does clopidogrel + aspirin, compared with aspirin alone, reduce a composite outcome of death from cardiovascular causes, acute myocardial infarction and stroke?

The Heparin Citrate Study

28 April 2016 Phil McGlone Intensive Care Medicine 3 comments

In critically ill patients requiring continuous renal replacement therapy (CRRT), does regional anticoagulation with citrate prolong circuit life compared to heparin and protamine?

ANNEXA

5 February 2016 Jamie Plumb Emergency Medicine, Intensive Care Medicine, Peri-operative Medicine Leave a comment

In healthy adults taking either apixaban (ANNEXA-A) or rivaroxaban (ANNEXA-R) does andexanet alfa compared to placebo normalise anticoagulation?

Idarucizumab for Dabigatran Reversal

4 September 2015 David Slessor Emergency Medicine, Intensive Care Medicine, Peri-operative Medicine One comment

In patients taking dabigatran, who present with serious bleeding or require urgent surgery/intervention is idarucizumab safe and efficacious for the reversal of anticoagulation?

BRIDGE Study

21 August 2015 Steve Mathieu Peri-operative Medicine One comment

In elective surgical patients with atrial fibrillation who are suspending their normal warfarin peri-operatively, does no bridging anticoagulation compared to bridging anticoagulation with dalteparin increase the incidence of thromboembolism or reduce the incidence of major bleeding?