A compendium of critical appraisals in Intensive Care Medicine research and related specialties
Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation Semler. N Engl J Med 2022; 387:1759-1769. DOI: 10.1056/NEJMoa2208415 Clinical Question In patients receiving invasive mechanical ventilation, does a target oxygen saturation of 90%, 94%, or 98% increase days alive and free of mechanical ventilation at 28 days? Background Despite the ubiquity of oxygen therapy in the critical care setting, the […]
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In comatose patients following cardiac arrest does a restrictive compared with a liberal oxygenation strategy, reduce death or survival at discharge with a poor neurological outcome?
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In neonates undergoing elective endotracheal intubation, does nasal high-flow therapy compared with standard care, improve 1st pass success without physiological instability?
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In adult patients undergoing rapid sequence intubation for emergency surgery, does pre-oxygenation with high-flow nasal oxygen, compared with standard face-mask oxygen, reduce the incidence of oxygen desaturation?
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In patients with acute hypoxaemic respiratory failure, does a lower vs higher oxygenation target reduce mortality at 90 days?
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In mechanically ventilated ICU patients does a conservative use of oxygen therapy compared to usual oxygen therapy affect the number of ventilator-free-days?
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In patients at high risk of respiratory complications after cardiac surgery, does the routine application of high-flow nasal oxygen compared to standard oxygen reduce hospital length of stay?
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In adult critically ill patients with hypoxemic respiratory failure necessitating intubation, does high-flow nasal cannula (HFNC) compared to bag-valve-mask (BVM) for both pre-oxygenation and oxygenation during intubation reduce desaturation?
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In immunocompromised patients with acute hypoxic respiratory failure (AHRF), does the use of high flow oxygen as opposed to standard oxygen therapy, reduce 28 day mortality?
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In infants (<12 months) with bronchiolitis and hypoxaemia (saturations <92%) in the emergency department or general paediatric ward, does early treatment with high flow therapy versus standard oxygen therapy result in fewer infants having treatment failure that leads to escalation of care?
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