A compendium of critical appraisals in Intensive Care Medicine research and related specialties
A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline L McIntyre. NEJM 2025; DOI: 10.1056/NEJMoa2416761 Clinical Question In hospitalised patients, does the use of Lactated Ringers (LR) vs Normal Saline (NS) lower the incidence of death or readmission to the hospital within 90 days after the index admission? Background Fluid choice (balanced solutions vs NS) has been widely […]
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In adult patients with acute decompensated heart failure (ADHF), does the addition of acetazolamide to loop diuretics improve decongestion by day 3?
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In patients with sepsis-induced hypotension does a restrictive fluid strategy (with early vasopressor usage) compared to a liberal fluid strategy result in lower mortality before discharge by day 90?
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Effect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation @DerekRussellMD. JAMA; 328(3):270-279. doi:10.1001/jama.2022.9792 Clinical Question In critically ill adult patients undergoing tracheal intubation and positive pressure ventilation, does intravenous infusion of a 500ml fluid bolus vs no fluid bolus, decrease the incidence of cardiovascular collapse during, or shortly after the procedure? Background Tracheal intubation […]
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In adults with acute pancreatitis does aggressive fluid resuscitation compared to moderate resuscitation result in a reduction in the development of moderately severe or severe pancreatitis?
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In adult patients in ICU with septic shock, does a restrictive approach to fluid therapy compared to a standard care result in fewer deaths at day 90?
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Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults Finfer S, NEJM, 2022; DOI: 10.1056/NEJMoa2114464 Clinical Question In critically ill adults does the use of a balanced multielectrolyte solution (BMES, Plasmalyte 148), as opposed to 0.9% Sodium Chloride, for fluid resuscitation and therapy result in reduced 90 day mortality? Background Fluid administration is a key component of critical care therapy […]
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In adult intensive care patients does the use of a balanced crystalloid compared to 0.9% saline reduce 90-day all-cause mortality?
In adult intensive care patients needing administration of resuscitation fluids, does the slow infusion compared to a fast infusion of a fluid boluses reduce 90-day all-cause mortality?
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Transfusion Volume for Children with Severe Anaemia in Africa K.Maitland. New England Journal of Medicine August 1st 2019; 381:5; 420-431. doi: 10.1056/NEJMoa1900100 Clinical Question In African children presenting to hospital with severe anaemia, is a blood transfusion volume of 30 ml/kg superior to 20 ml/kg in reducing 28 day mortality? Background Severe anaemia is a major cause of death and […]
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In children with septic shock, does a restricted fluid bolus volume, compared with a standard fluid bolus volume, improve outcomes?
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