Classic Trial
In adult patients in ICU with septic shock, does a restrictive approach to fluid therapy compared to a standard care result in fewer deaths at day 90?
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PLUS Study
Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults Finfer S, NEJM, 2022; DOI: 10.1056/NEJMoa2114464 Clinical Question In critically ill adults does the use of a balanced multielectrolyte solution (BMES, Plasmalyte 148), as opposed to 0.9% Sodium Chloride, for fluid resuscitation and therapy result in reduced 90 day mortality? Background Fluid administration is a key component of critical care therapy […]
Continue reading »BaSICS
In adult intensive care patients does the use of a balanced crystalloid compared to 0.9% saline reduce 90-day all-cause mortality?
In adult intensive care patients needing administration of resuscitation fluids, does the slow infusion compared to a fast infusion of a fluid boluses reduce 90-day all-cause mortality?
Continue reading »TRACT Transfusion Volume
Transfusion Volume for Children with Severe Anaemia in Africa K.Maitland. New England Journal of Medicine August 1st 2019; 381:5; 420-431. doi: 10.1056/NEJMoa1900100 Clinical Question In African children presenting to hospital with severe anaemia, is a blood transfusion volume of 30 ml/kg superior to 20 ml/kg in reducing 28 day mortality? Background Severe anaemia is a major cause of death and […]
Continue reading »FiSh
In children with septic shock, does a restricted fluid bolus volume, compared with a standard fluid bolus volume, improve outcomes?
Continue reading »6S
In critically ill adults with severe sepsis, does 6% hydroxyethyl starch (HES) compared to Ringer’s acetate reduce the incidence of death or end stage kidney failure?
Continue reading »SHoC-ED
In selected non-trauma patients presenting to the emergency department with undifferentiated hypotension, does a standardised point-of-care ultrasound protocol, compared with usual care, improve 30 day or hospital survival?
Continue reading »RELIEF
In adult patients undergoing major elective abdominal surgery, does a restrictive fluid regimen compared with a liberal fluid regimen reduce complications and improved disability-free survival?
Continue reading »SALT-ED
In non-critically ill adult patients admitted to hospital from the Emergency Department, does the administration of a balanced salt solution compared with normal saline, reduce hospital free days to day 28?
Continue reading »SMART
In critically ill patients does the administration of balanced crystalloids compared with saline, reduce a 30 day composite outcome of death, new renal replacement therapy or persistent renal dysfunction?
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