Renal – The Bottom Line

IDEAL-ICU

9 November 2018 David Slessor Intensive Care Medicine Leave a comment

patients with septic shock and severe acute kidney injury, does early vs. delayed renal replacement therapy improve 90 day mortality?

Atan

24 August 2018 Celia Bradford Intensive Care Medicine Leave a comment

In critically ill patients on noradrenaline for haemodynamic support, who required hemofiltration for AKI, does the use of a high cutoff hemofilter compared with a standard hemofilter impact the median hours of noradrenaline-free time at day 7?

BICAR-ICU

22 June 2018 Steve Mathieu Intensive Care Medicine 4 comments

In critically ill patients with severe metabolic acidaemia (pH ≤7⋅20), does the infusion of sodium bicarbonate, compared with no infusion, to reach and maintain a targeted pH of 7⋅30 decrease the primary composite outcome of mortality by day 28 or the presence of at least one organ failure at day 7?

SALT-EM

2 March 2018 Fraser Magee Emergency Medicine, Intensive Care Medicine Leave a comment

In non-critically ill adult patients admitted to hospital from the Emergency Department, does the administration of a balanced salt solution compared with normal saline, reduce hospital free days to day 28?

SMART

2 March 2018 Celia Bradford Intensive Care Medicine Leave a comment

In critically ill patients does the administration of balanced crystalloids compared with saline, reduce a 30 day composite outcome of death, new renal replacement therapy or persistent renal dysfunction?

ELAIN FOLLOW-UP

16 February 2018 Celia Bradford Intensive Care Medicine Leave a comment

In adult critically ill patients, with acute kidney injury, does early initiation of RRT compared to delayed initiation of RRT reduce the composite endpoint of MAKE365; consisting of death, RRT and persistent renal dysfunction at one year?

PRESERVE

1 December 2017 Fraser Magee Emergency Medicine, Intensive Care Medicine, Peri-operative Medicine One comment

In high-risk patients undergoing angiography, does the administration of bicarbonate and/or acetylcysteine, compared with placebo, prevent major adverse events and acute kidney injury?

SPARK

4 August 2017 Celia Bradford Intensive Care Medicine Leave a comment

In critically ill patients, with mild renal failure, does furosemide infusion compared to placebo worsen kidney function?

AMACING

10 March 2017 Celia Bradford Intensive Care Medicine 2 comments

In high-risk patients receiving contrast medium, does prophylactic hydration with normal saline compared to no prophylaxis impact the rate of contrast-induced nephropathy?