David Slessor

Clinical Decisions on Beta Blockers After MI

23 April 2025 David Slessor Blog, Evidence-based Medicine Leave a comment

Clinical Question In adults with acute myocardial infarction and preserved left ventricular ejection fraction (LVEF), does initiating beta-blocker therapy at discharge, compared with no beta-blocker therapy, reduce the risk of death or recurrent myocardial infarction? Background Beta-blockers have long been a cornerstone of post–myocardial infarction care, largely based on trials conducted in the pre-reperfusion era. However, with modern advances […]

Validation of the MIRACLE 2 Score for Prognostication After OOHCA

22 March 2024 David Slessor Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

In patient with out-of-hospital cardiac arrest, how does the MIRACLE2 score compare with previously reporting scoring systems, for predicting poor neurological outcome at hospital discharge?

AID-ICU

21 April 2023 David Slessor Intensive Care Medicine, Summaries Leave a comment

In patients in the ICU with delirium, does haloperidol compared with placebo, increase the number of days alive and out of the hospital at 90 days?

DOSEVF

10 November 2022 David Slessor Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

In patients with refractory VF, does Double Sequential External Defibrillation or Vector-change Defibrillation improve survival to hospital discharge?

BOX (Oxygen)

8 November 2022 David Slessor Intensive Care Medicine, Summaries Leave a comment

In comatose patients following cardiac arrest does a restrictive compared with a liberal oxygenation strategy, reduce death or survival at discharge with a poor neurological outcome?

SHINE

29 April 2022 David Slessor Intensive Care Medicine, Summaries Leave a comment

In neonates undergoing elective endotracheal intubation, does nasal high-flow therapy compared with standard care, improve 1st pass success without physiological instability?

COSMIC-EOL

5 March 2022 David Slessor Intensive Care Medicine, Summaries Leave a comment

In relatives of patients dying in the ICU, does a 3 step support strategy compared with standard care reduce prolonged grief disorder?

Terminal QRS distortion

25 February 2022 David Slessor Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

Terminal QRS distortion is present in anterior myocardial infarction but absent in early repolarization Lee. @smithECGBlog. The American Journal of Emergency Medicine;2016;34(11):2182-2185 Clinical Question In patients with benign early repolarisation, is there the absence of terminal QRS distortion on the ECG? Background For patients who present with chest pain, it can be difficult to distinguish between ECG findings of benign […]

SUBCLAVIAN LINES

28 January 2022 David Slessor Emergency Medicine, Intensive Care Medicine Leave a comment

In patients undergoing elective neurosurgery, is a supraclavicular in-plane ultrasound guided approach, compared with an infra-clavicular out-of-plane ultrasound guided approach, non-inferior for catheterisation-related complication?

COMBAT-COVID

10 December 2021 David Slessor Intensive Care Medicine, Summaries Leave a comment

In mechanically ventilated patients with COVID-19 and severe endotheliopathy, does prostacylin compared with placebo, improve days alive without ventilation by day 28?

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