Critical Care Evidence Updates – August 2025
Randomised Controlled Trials
Continuous versus bolus norepinephrine administration and arterial blood pressure stability during induction of general anaesthesia in high-risk noncardiac surgery patients: a randomised trial British Journal of Anaesthesia
Dalbavancin for Treatment of Staphylococcus aureus Bacteremia – The DOTS Randomized Clinical Trial JAMA
Early Cardiac Rehabilitation for Critically Ill Patients With Acute Decompensated Heart Failure – A Randomized Clinical Trial JAMA Network Open
Economic analysis of high-flow nasal oxygen compared with noninvasive ventilation in patients with acute respiratory failure: results from the RENOVATE randomized clinical trial Respiratory Medicine
Effect of albumin infusion in patients with predicted severe acute pancreatitis: A randomized controlled trial Pancreatology
Effect of remimazolam besylate versus midazolam on time to extubation in critically ill, mechanically ventilated patients: a randomized controlled trial Frontiers in Medicine
Effects of Preoxygenation With Intratracheal Suctioning During Extubation: An Alternating Cluster-Controlled Trial (INtratracheal suctioning and oxygenation AT Extubation [INNOVATE]) Critical Care Medicine
Enteral protein supplementation in critically ill trauma and surgical patients: A single-center randomized clinical trial Journal of Trauma and Acute Care Surgery
Exercise in patients with a tracheostomy and speaking valve: a randomised crossover-controlled trial Critical Care
Functional Status After Delirium in the ICU: A 1-Year Follow-Up of the Agents Intervening Against Delirium in the ICU (AID-ICU) Trial Critical Care Medicine
Gabapentin for pain management following major surgery: a placebo controlled, double blind, randomized clinical trial (The GAP Study) Anesthesiology
Higher vs standard mean arterial pressure target in the immediate postoperative period of liver transplantation to prevent acute kidney injury: A randomized clinical trial (LIVER-PAM) American Journal of Transplantation
Immediate “sipping” vs. delayed oral fluid intake after extubation: A randomized controlled trial Journal of Critical Care
Low-Dose Hydrocortisone in Cirrhotic Patients With Septic Shock: A Double-Blind Randomised Placebo-Controlled Trial Liver International
Personalized driving pressure-guided positive end-expiratory pressure in patients at risk of postoperative respiratory failure (IMPROVE-2): a multicenter, pragmatic, randomized clinical trial Intensive Care Medicine
Prophylactic VA-ECMO During Complex High-Risk PCI: A Randomized Controlled Trial JACC
ROBotic-assisted Early Mobilization in ventilated surgical critically ill patients (ROBEM-I)—A randomized, controlled, outcome-assessor-blinded pilot study Anaesthesia Critical Care & Pain Medicine
Safety of intermittent versus continuous enteral nutrition in critically ill patients. Randomized clinical trial Enfermería Intensiva (English ed.)
The clinical outcome of Montelukast versus co-enzyme Q10 in adult patients with sepsis: A randomized controlled clinical trial Journal of Critical Care
Therapeutic plasma exchange in patients with acute liver failure: A pilot randomized controlled trial Journal of Clinical and Experimental Hepatology
Other Guidance/Reports
2025 ADS/ANZCA/GESA/NACOS clinical practice recommendations on the peri-procedural use of GLP-1/GIP receptor agonists Anaesthesia and Intensive Care
2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Infliximab Clinical Infectious Diseases
2025 ESC Guidelines for the management of myocarditis and pericarditis: Developed by the task force for the management of myocarditis and pericarditis of the European Society of Cardiology (ESC) Endorsed by the Association for European Paediatric and Congenital Cardiology (AEPC) and the European Association for Cardio-Thoracic Surgery (EACTS) European Heart Journal
AASLD AST Practice Guideline on Adult Liver Transplantation: Diagnosis and management of Graft-Related complications Liver Transplantation
Acute heart failure in non-cardiac surgery: A clinical consensus statement of the Association for Acute CardioVascular Care (ACVC) and the Heart Failure Association (HFA) of the ESC European Heart Journal
Best Management Practices on Temporary Mechanical Circulatory Support: Joint Consensus Report of the PeriOperative Quality Initiative and the Enhanced Recovery After Surgery Cardiac Society The Annals of Thoracic Surgery
Blood Product Transfusion in Adult Intensive Care Unit: An Indian Society of Critical Care Medicine Position Paper Indian Journal of Critical Care Medicine
Clinical guidelines and strategic plan for the prevention, diagnosis and treatment of delirium: The zero delirium project Revista Española de Anestesiología y Reanimación (English Edition)
European Society of Intensive Care Medicine Clinical Practice Guideline on fluid therapy in adult critically ill patients: Part 3—fluid removal at de-escalation phase Intensive Care Medicine
Red Cell Transfusion in Acute Myocardial Infarction: AABB International Clinical Practice Guidelines Annals of Internal Medicine
Cochrane
Early versus late tracheostomy in people with multiple trauma
Exercise therapy for the treatment of delirium in the intensive care unit
Primary Research
A phase I trial evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenously administered low-anticoagulant heparin (M6229) in critically ill sepsis patients Intensive Care Medicine Experimental
Advanced vascular ultrasound prior to radial artery cannulation on the intensive care unit: A feasibility service evaluation Journal of the Intensive Care Society
Assessing the carbon footprint of the initial 24 h post-severe trauma admission in a French ICU: a pilot study Annals of Intensive Care
Association Between Whole Blood Cell-Derived Inflammatory Markers and All-Cause Mortality in Patients with Sepsis-Associated Acute Kidney Injury: A Retrospective Study Based on the MIMIC-IV Database Journal of Intensive Care Medicine
Association of Breathing Effort With Survival in Patients With Acute Respiratory Distress Syndrome Critical Care Medicine
Comparative evaluation of spontaneous breathing trial techniques for ventilator weaning: a bench study Intensive Care Medicine Experimental
Deep Needles and Shallow Veins. Ultrasound Estimation of Internal Jugular Mid-Vein and Posterior Wall Depth During Central Line Placement in Trendelenburg Position Journal of Intensive Care Medicine
Demographics and outcome of Legionella pneumonia in the intensive care unit: a retrospective multicenter cohort study Critical Care
Diagnostic yield and adverse events of liver biopsy in intensive-care-unit patients: a multicenter retrospective observational cohort study Annals of Intensive Care
Effect of Comprehensive Medication Management on Mortality in Critically Ill Patients Critical Care Medicine
Endothelial dysfunction in critically ill patients with sepsis and COVID-19 using the albumin transudation rate: A pilot study Journal of Critical Care
Explainable machine learning for discontinuation of therapeutic antibiotics in intensive care patients Journal of Critical Care
Extracorporeal carbon dioxide removal for the treatment of acute hypoxaemic respiratory failure: the REST RCT Health Technology Assessment
Gut microbiota differs between ICU patients admitted for cardiac arrest and other causes: a secondary, propensity-matched cohort analysis Intensive Care Medicine Experimental
Hyperoxia and End-Organ Complications Among Cardiogenic Shock Patients Supported by Veno-Arterial Extracorporeal Membrane Oxygenation Critical Care Medicine
Impact of acoustic environment in intensive care unit on nurses’ well-being during COVID-19: A qualitative interview study Intensive and Critical Care Nursing
Impact of frailty on in-hospital outcomes in nonagenarian ICU patients: a binational multicenter analysis of 8,220 cases Critical Care
Inferior Vena Cava Thrombosis Associated with Endovascular Cooling Catheters: Impact on Clinical Outcomes Resuscitation
Lessons learnt from moving an intensive care unit into a new hospital Journal of the Intensive Care Society
Levetiracetam dosing in critically ill patients receiving prolonged intermittent renal replacement therapy Journal of Critical Care
Life-Supporting Treatment Limitations in Patients Who Die Within 48 Hours After ICU Admission: A French, Multicenter, Observational, Exploratory Study Critical Care Explorations
Measuring alarm fatigue in intensive care units: translation and validation of the Charité Alarm Fatigue Questionnaire: a multi-centre study Journal of Critical Care
Meropenem and piperacillin/tazobactam optimised dosing regimens for critically ill patients receiving renal replacement therapy Intensive Care Medicine
Mitigating Skin Failure in Critically Ill Patients at the End of Life: A Case Report Critical Care Nurse
Mixed methods evaluation of a digital tool to support the transfer of medication information from ICU to ward Journal of Critical Care
Model establishment based on clinical data from patient monitors: Optimising night-time alarms in intensive care units Intensive and Critical Care Nursing
Multimodal Noninvasive Monitoring of Arterial Pressure: Do Limitations of Finger Cuff Monitoring Compromise Upper Arm Measurements? A Post Hoc Analysis of Two Prospective Cohorts Critical Care Medicine
Multimodal sedation guided by processed electroencephalography and autonomic nervous system monitoring for spinal cord stimulator implantation: retrospective identification of anesthetic drug doses Journal of Anesthesia, Analgesia and Critical Care
Norepinephrine use at extubation in critically ill patients with obesity: a cohort study with multicenter validation Intensive Care Medicine
Obesity- and Lipid-Related Traits May Causally Contribute to Sepsis-Associated Acute Kidney Injury Critical Care Medicine
Obesity and nutrition risk in patients admitted to intensive care after cardiac arrest: A multicentre cohort study Resuscitation
Palliative Care Specialty Nursing in Medical Intensive Care Units Critical Care Nurse
Physiological and clinical effects of two ultraprotective ventilation strategies in patients with veno-venous extracorporeal membrane oxygenation: the ECMOVENT study Annals of Intensive Care
Portable handheld ultrasound for VExUS assessment in critical care: Reliability and time efficiency in resident-led examinations Journal of Critical Care
Prior Use of Renin-Angiotensin System Inhibitors and Risk of Renal Replacement Therapy in Critically Ill Elderly Patients With Sepsis: A Population-Based Cohort Study Critical Care Explorations
Reducing plastic in single-use central line insertion packs: A mixed methods observational study Anaesthesia and Intensive Care
Respiratory management of critically ill pneumocystis pneumonia patients: a multicenter retrospective study Annals of Intensive Care
Revolutionizing recovery: The impact of designed digital care therapy on preventing Post-Intensive care syndrome Intensive and Critical Care Nursing
Serum proteomes and their prognostic values in sepsis patients admitted to a medical intensive care unit: a single-center study using SWATH-MS proteomics Annals of Intensive Care
Serum sodium trajectories impact clinical outcomes in extracorporeal resuscitation of cardiac arrest: A multicenter retrospective cohort study Resuscitation Plus
The Impact of the COVID-19 Pandemic on Healthcare Associated Bloodstream Infections in Scottish Intensive Care Units: A Retrospective Cohort Study Journal of Intensive Care Medicine
The Novel Application of Surgiflo and Successful Hemostasis of Refractory Intrapulmonary Hemorrhage in Extracorporeal Membrane Oxygenation Critical Care Explorations
The visitors’ book as a family-centered care tool: A corpus-based, multi-site study on the implementation of a narrative care practice in ICU Intensive and Critical Care Nursing
Two paths to paralysis: A multicenter comparison of cisatracurium to atracurium in the management of acute respiratory distress syndrome Journal of Critical Care
Virtual family participation in adult intensive care unit rounds: A multicenter pilot feasibility cohort study Journal of Critical Care
Metadata
Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash
