Critical Care Evidence Updates – October 2025
Randomised Controlled Trials
Adjunctive terlipressin versus placebo in the treatment of refractory septic shock: a randomized, placebo-controlled trial Critical Care
Applying positive end-expiratory pressure to facemask ventilation improves post-induction lung atelectasis: a three-arm randomized controlled trial BMC Anesthesiology
Cefiderocol versus standard therapy for hospital-acquired and health-care-associated Gram-negative bacterial bloodstream infection (the GAME CHANGER trial): an open-label, parallel-group, randomised trial The Lancet Infectious Diseases
A multicentre randomised clinical trial European Journal of Anaesthesiology
Dexmedetomidine for treatment of hyperactive delirium in non-intubated ICU patients: the 4D randomized clinical trial Intensive Care Medicine
Effects of The Caregiver Pathway intervention on symptoms of post-intensive care syndrome among family caregivers to critically ill patients: long-term results from a randomized controlled trial Intensive Care Medicine
Multicenter randomized trial assessing efficacy and safety of aerosolized dornase Alfa in COVID-19 ARDS Scientific Reports
Phenylephrine Vs. Norepinephrine on the Renin–Angiotensin–Aldosterone System and Postoperative Complications in Acute Abdomen Emergency Surgery: A Randomized Controlled Trial Critical Care Medicine
Positive communication for decreasing burnout in intensive-care-unit staff: a cluster-randomized trial Annals of Intensive Care
Relationship Between Phenotyping and Individualized Absolute Risk Differences in Sepsis: A Secondary Analysis of Two Approaches in Two Multicenter Trials Critical Care Explorations
Safety and efficacy of inhaled PEG-ADM in ARDS patients: a randomised controlled trial Critical Care
Slow-Tempo Music and Delirium/Coma-Free Days Among Older Adults Undergoing Mechanical Ventilation A Randomized Clinical Trial JAMA Internal Medicine
Targeted Tissue Perfusion Versus Macrocirculatory-Guided Standard Care in Patients With Septic Shock: A Randomized Clinical Trial—The TARTARE-2S Trial Critical Care Medicine
The effectiveness of white noise for sleep quality in patients admitted to the intensive care unit: a randomized controlled trial Intensive and Critical Care Nursing
The Efficacy of a Multidisciplinary Peri-anesthetic Management Bundle for Alleviating Delirium after Thoracic Surgery: A Randomized Clinical Trial Journal of Cardiothoracic and Vascular Anesthesia
Other Guidance/Reports
British societies guideline on the management of emergencies in patients on extracorporeal membrane oxygenation Intensive Care Medicine
Defining the scope of point-of-care ultrasound in internal medicine: a consensus statement by the point-of-care special interest group of the Internal Medicine Society of Australia and New Zealand Internal Medicine Journal
EBCP Expert consensus statement on basic qualifications and competencies for clinical perfusionists in Europe developed in collaboration with EACTS and EACTAIC: Knowledge, skills, and competencies required for contemporary clinical perfusion practice European Journal of Cardio-Thoracic Surgery
ELSO 2025 Narrative Guideline on the Use of ECMO for Accidental Hypothermia ASAIO Journal
European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2025 Post-Resuscitation Care Resuscitation
European Resuscitation Council Guidelines 2025 Adult Advanced Life Support Resuscitation
European Resuscitation Council Guidelines 2025 Adult Basic Life Support Resuscitation
European Resuscitation Council Guidelines 2025 Ethics in Resuscitation Resuscitation
European Resuscitation Council Guidelines 2025 Special Circumstances in Resuscitation Resuscitation
How to Do Echo in Septic Cardiomyopathy: A Consensus Statement of the Italian Society of Echocardiography and Cardiovascular Imaging Journal of Cardiovascular Echography
Kidney & extracorporeal support interactions: a narrative review Current Opinion in Critical Care
Kidney-organ interactions: recent advances and clinical implications Current Opinion in Critical Care
Thoracic trauma WSES-AAST guidelines World Journal of Emergency Surgery
Cochrane
Molnupiravir for treating COVID‐19
Primary Research
Accuracy of continuous glucose monitoring in critically ill patients Critical Care and Resuscitation
Acute Brain Injury in COVID-19 Versus Influenza A Patients on Venovenous Extracorporeal Membrane Oxygenation: A Propensity Score Matching Analysis of the Extracorporeal Life Support Organization Registry Critical Care Medicine
Adrenaline and return of spontaneous circulation during in-hospital cardiac arrest Resuscitation Plus
An Interpretable Machine Learning Model for Early Multitemporal Prediction of Onset of Acute Kidney Injury in Intensive Care Unit Patients with Severe Trauma Journal of Intensive Care Medicine
Analysis of Mortality and Length of Stay Associated With Implementation of a Large Telecritical Care Program in an Integrated Healthcare System Critical Care Medicine
Assessment of outcomes in postaneurysmal subarachnoid bleed patients admitted to the intensive care unit utilizing the subarachnoid haemorrhage international trialist clinicoradiological prediction model for dichotomised functional outcome and mortality Critical Care and Resuscitation
Association between early administration of mucoactive agents and in-hospital mortality in patients with pneumonia requiring mechanical ventilation: a nationwide cohort study Journal of Intensive Care
Association Between Early Arterial Catheterization and Prognosis in Patients with Septic Shock: A Retrospective Propensity Score Analysis Journal of Intensive Care Medicine
Association of appropriate empiric antimicrobial therapy with acute kidney injury in gram-negative sepsis Journal of the Intensive Care Society
Association of medication-induced deep sedation and emotional distress during mechanical ventilation with loss of independent living: an observational cohort study The Lancet Respiratory Medicine
Associations of positive end-expiratory pressure (PEEP) with extubation failure and clinical outcomes in invasively ventilated patients with acute brain injury: A secondary analysis of the ENIO study Journal of Critical Care
Characteristics of ventilator weaning in patients intubated for Guillain–Barré syndrome or myasthenia gravis: a nationwide multicenter study Intensive Care Medicine
Circulating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS Critical Care
Combined Ultrasound Measurements of Diaphragm and Intercostal Muscles in Mechanically Ventilated Patients with Sepsis: A Novel Approach to Optimize Extubation Prediction Journal of Intensive Care Medicine
Critical hyponatraemia secondary to severe bilateral renal artery stenosis requiring intensive care – an unusual aetiopathogenesis for a common problem Anaesthesia and Intensive Care
Critical Illness-Associated Hyperglycemia and New-Onset Diabetes: A Retrospective Cohort Study Critical Care Medicine
Determinants of ICU memories and the impact on the development and trajectory of post-traumatic stress symptoms: a multicenter longitudinal cohort study Intensive Care Medicine
Discovery of a resistant cohort to acute kidney injury: insights from patients with septic shock Critical Care
Do diabetes and poor control of acute stress-related hyperglycemia increase the risk of ICU-acquired infections? A retrospective assessment in patients with septic shock Annals of Intensive Care
Documentation and evaluation of care of dying patients Critical Care and Resuscitation
Does obesity impact on weaning from invasive ventilation: a secondary analysis of the WEAN SAFE study Annals of Intensive Care
Dual doppler dynamics: integrating femoral venous doppler and VExUS for predicting organ dysfunction in acute heart failure Journal of Anesthesia, Analgesia and Critical Care
Dynamic mechanical power at the bedside: A validation study in volume-controlled and pressure-controlled ventilation modes Journal of Critical Care
Effect of early intubation on patient-centered outcomes in urosepsis: a retrospective multicenter cohort study Journal of Intensive Care
Effect of time to extracorporeal cardiopulmonary resuscitation on survival outcomes in in-hospital cardiac arrest patients Resuscitation
Electrochemical skin conductance is associated with peripheral tissue hypoperfusion in septic patients Intensive Care Medicine Experimental
Evaluation of 6-hour urine creatinine clearance as the kidney component in the SOFA score: An observational cohort study Journal of Intensive Medicine
Explainable AI identifies key biomarkers for acute kidney injury prediction in the ICU Intensive Care Medicine Experimental
Factors associated with ICU mortality and long-term outcomes in immunocompromised patients admitted to the intensive care unit for acute respiratory failure Annals of Intensive Care
Five Years After Extracorporeal Membrane Oxygenation: A Prospective Cohort Study of Health-Related Quality of Life and Patient Outcomes Critical Care Medicine
Hyperosmolar Dehydration in Sepsis: Implications for Initial Fluid Management Critical Care Medicine
Impact of body mass index on 90-day survival in patients in cardiogenic shock treated with V-A ECMO: A propensity weighted analysis Journal of Critical Care
Impact of ICU Length of Stay and Illness Severity on Rehabilitation Progress and Functional Recovery: A Secondary Analysis of the Japanese Rehabilitation and Risk Factors on the Post-Intensive Care Syndrome (J-RELIFE) Prospective Registry Critical Care Explorations
Impact of Left Ventricular Venting on Acute Brain Injury in Patients With Cardiogenic Shock: An Extracorporeal Life Support Organization Registry Analysis Critical Care Medicine
Impact of respiratory viruses detection on outcomes in ventilated nosocomial pneumonia: an exposed/unexposed study Annals of Intensive Care
Improving alarm management to reduce alarm fatigue in critical care: a mixed-methods study Intensive and Critical Care Nursing
Incidence and outcomes of extubation failure in mechanically ventilated patients with cirrhosis: a post-hoc analysis of a prospective multicenter study Annals of Intensive Care
Integrating Rapid Cardiopulmonary and Gastric Ultrasound for Emergency Airway Management in Critically Ill Patients: A Case Series of Resident-Performed Echocardiographic Assessment Using Subcostal-Only-View in Physiologically Difficult Airway Critical Care Explorations
Management of adult organ donors after brain death in ICU: insights from an Italian survey Journal of Anesthesia, Analgesia and Critical Care
Methylene Blue Administration in Septic Shock: A Retrospective Cohort Study Critical Care Medicine
Multimodal assessment of peripheral perfusion in critically ill patients: a pilot study Annals of Intensive Care
Neuromuscular blockade and their monitoring in the intensive care unit: a multicenter observational prospective study Annals of Intensive Care
Outcomes of carbapenem-resistant Acinetobacter baumannii bloodstream infections in intensive care units and prognostic effect of different antimicrobial regimens Annals of Intensive Care
PEEP-AKI-COVID ICU: Effect of positive end-expiratory pressure on acute kidney injury development in patients with COVID-19-associated acute respiratory distress syndrome: an ancillary analysis of the COVID-ICU study Journal of Intensive Care
Perfusion variables and hemodynamic phenotypes during fluid removal via net ultrafiltration in continuous renal replacement therapy: a retrospective single-center cohort study Journal of Critical Care
Prediction of 48-h Intensive Care Unit Mortality in Hospitalized Cancer Patients: Performance of the EPIC Deterioration Index and Sequential Organ Failure Assessment Score Journal of Intensive Care Medicine
Preventing unplanned extubations: A test bench simulation comparing endotracheal tube securing techniques in acute care settings Journal of Critical Care
Protective mechanical ventilation controlled by the real-time mechanical power measurement Journal of Clinical Monitoring and Computing
Randomized trial of activated vitamin D for acute kidney injury prevention in critically ill patients JCI Insight
Respiratory effects of trunk inclination in obese and non-obese patients mechanically ventilated for ARDS Critical Care
Sepsis in the absence of fever: Determining the criteria for and feasibility of future therapeutic temperature management trials Critical Care and Resuscitation
Significance of positive semi-quantitative PCR tests on bronchoalveolar lavage for Pneumocystis jirovecii pneumonia in HIV-negative immunocompromised ICU patients with acute respiratory failure Annals of Intensive Care
Six years of a clinical communication intervention in shared decision-making to promote documentation of goals of care for critically ill patients with a life-limiting illness Critical Care and Resuscitation
The ADVanced Organ Support (ADVOS) hemodialysis system balances blood pH within 24 h in patients with multiple organ failure and hypercapnic acidosis Intensive Care Medicine Experimental
The lower limit margin: a determinant of autoregulatory sensitivity to changes in cerebral perfusion pressure Critical Care
The Relationship Between Antibiotic Administration Timing and Short-Term and Long-Term Prognosis in Elderly Septic Patients Journal of Intensive Care Medicine
Temperature profiles in adult intensive care unit patients treated for infection in a tertiary intensive care unit: A single-centre prospective observational cohort study Critical Care and Resuscitation
Tidal volume and mortality during extracorporeal membrane oxygenation for acute respiratory distress syndrome: a multicenter observational cohort study Annals of Intensive Care
Timing of inotropic support is associated with mortality in patients with acute decompensated heart failure-associated cardiogenic shock Intensive Care Medicine Experimental
Transesophageal lung ultrasound score is associated with arterial oxygenation and clinical outcomes in mechanically ventilated critically ill patients Intensive Care Medicine Experimental
Utility of the NELA score and other variables in predicting the need for ICU admission post emergency laparotomy Anaesthesia and Intensive Care
Vasoactive drugs and the distribution of crystalloid fluid during acute sepsis Journal of Intensive Medicine
Metadata
Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash
