Critical Care Evidence Updates – April 2026
Randomised Controlled Trials
0.9% sodium chloride versus ringer’s lactate in the management of severe diabetic ketoacidosis: A randomized trial Medicina Intensiva
Adjunctive betamethasone treatment of hypoxaemic adults hospitalised with Mycoplasma pneumoniae community-acquired pneumonia: an open-label, multicentre, randomised, controlled trial The Lancet Regional Health Europe
Efficacy and Tolerability of Non-Routine Gastric Residual Volume Monitoring in Mechanically Ventilated Adults Receiving Early Enteral Nutrition: A Randomised Controlled Non-Inferiority Trial Nursing in Critical Care
From Intensive Care to Recovery: Feasibility of a Randomised Controlled Study Design Evaluating a Cognitive Rehabilitation Intervention for Critically Ill Patients Nursing in Critical Care
High-Flow Nasal Oxygen Therapy After Cardiac Surgery A Randomized Clinical Trial JAMA Network Open
High-frequency oscillation improves mucus clearance and airway resistance in mechanically ventilated patients: a randomized clinical trial Annals of Intensive Care
Inferior vena cava dynamics during triggered breaths under different levels of pressure support and PEEP: A randomized crossover physiologic study Journal of Critical Care
Personalised viscoelastometry-guided systemic thrombolysis for high- and intermediate-high-risk acute pulmonary embolism in the ICU: a single-centre randomised controlled interventional feasibility trial Intensive Care Medicine Experimental
Whole genome sequencing precision medicine strategy to shorten treatment for rifampicin-resistant tuberculosis (SMARTT): a pragmatic, randomised, single-blind phase 4 trial The Lancet Respiratory Medicine
Other Guidance/Reports
2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Baricitinib vs. Tocilizumab Clinical Infectious Diseases
Post-intensive Care Syndrome (PICS): an American Association for the Surgery of Trauma Critical Care Committee Consensus Guideline – Defining, Recognizing, and Managing PICS Associated Physical Impairment, Cognitive Dysfunction, and Thromboinflammatory Dysregulation Trauma Surgery & Acute Care Open
Use of andexanet alfa: A British Society for Haematology position statement British Journal of Haematology
Cochrane
Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children
Liver support systems for adults with acute liver failure
Primary Research
Assessment of Pain Intensity Using Deep Learning Models in Non-Communicative Intensive Care Patients Nursing in Critical Care
Association Between Targeted Temperature Management and New-Onset Brain Disability in in-Hospital Cardiac Arrest Survivors: A Nationwide Cohort Study Journal of Intensive Care Medicine
Association of primary spoken language and noninvasive ventilation failure in hospitalized adults Journal of Critical Care
Awake Flexible Scope Intubation in Critically Ill Patients With Physiologically Difficult Airways: A Prospective, Observational Case Series Critical Care Explorations
Clinical Care Interaction and Patient Sleep in the Intensive Care Unit: A Secondary Data Analysis Nursing in Critical Care
Combined short- and mid-latency SSEP amplitudes for early prediction of favorable neurological recovery after cardiac arrest Resuscitation
Comparison between invasive radial and femoral arterial pressures and carotid tonometry in ICU patients: A physiological study Annals of Intensive Care
Current practices of SGLT2 inhibitor use and ketone monitoring in intensive care units: A multicentre observational study Critical Care and Resuscitation
Dexmedetomidine Use and Reduced In-hospital Mortality in ICU Patients with Delirium: A Retrospective Study Based on Two Observational Cohorts Journal of Intensive Care Medicine
Do ICU Admissions Following Rapid Response Events Differ by Patient Demographics? Journal of Intensive Care Medicine
Early Bronchoscopy and Duration of Mechanical Ventilation after Out-of-Hospital Cardiac Arrest Journal of Intensive Care Medicine
Early Sedation Intensity and Psychological Outcomes in Critically Ill Adults Nursing in Critical Care
Effect modification by chronic kidney disease on renal outcomes in septic shock patients undergoing high-MAP targeting: a secondary analysis of the OPTPRESS trial Journal of Intensive Care
Effect of Implementing a Nursing-Led SKINCARE Bundle for Preventing Medical Device–Related Pressure Injury in Critical Care Units Nursing in Critical Care
Effects of Early Versus Delayed Mechanical Thrombectomy on Outcomes in Intermediate-Risk Acute Pulmonary Embolism Critical Care Medicine
Effects of High-Flow Nasal Cannula and Helmet Continuous Positive Airway Pressure in Acute Hypoxemic Respiratory Failure Critical Care Medicine
Emotional Freedom Technique: Reducing Stress, Anxiety, and Burnout in Critical Care Nurses Critical Care Nurse
Enhanced Moisture-Focused, Nurse-Led Oral Care Improves Oral Health and Suppresses Bacterial Overgrowth in Mechanically Ventilated ICU Patients: A Quasi-Experimental Study Nursing in Critical Care
Exploring the potential impact of real-time ventilation feedback on the quality of manual bag ventilation in routine ICU practice. The FEED-BAG study Intensive and Critical Care Nursing
Exploring the Relationship Between Alarm Fatigue and Compassion Fatigue Among Critical Care Nurses Nursing in Critical Care
Family Presence During Invasive Procedures or Resuscitation, Nurse Perception and Preparedness Questionnaire (FPDIP/R-NPPQ): A Validity and Reliability Study Nursing in Critical Care
Hospital readmission after surviving sepsis: An analysis of infection recurrence, risk factors and long-term survival Journal of Critical Care
Impact of Verticalization Therapy in a Patient With Acute Respiratory Distress Syndrome and Obesity: A Case Report Critical Care Nurse
Improving sleep in ICUs through real-time sleep monitoring: a proof-of-concept study Annals of Intensive Care
Infectious meningitis and encephalitis: A primer for acute care practitioners Journal of the Intensive Care Society
Integrated or Parallel Configurations for Renal Replacement Therapy in Patients on VenoArterial Extracorporeal Membrane Oxygenation, a Single Center Retrospective Study Journal of Intensive Care Medicine
Ketamine Use in Critically Ill Patients: Insights into Depressive Symptoms and Hemodynamic Changes Journal of Intensive Care Medicine
Low versus standard calorie and protein feeding and renal dysfunction in ventilated adults with shock: a NUTRIREA-3 post hoc analysis Intensive Care Medicine
Neurological outcome of patients with a non-traumatic infratentorial cerebellar haematoma admitted to the intensive care unit Anaesthesia and Intensive Care
Out-the-Door, Dinosaur: Assessing Health Literacy to Improve Discharge Education Critical Care Nurse
Oxygen Stewardship in Adult Critical Care: A Quality Improvement Initiative Nursing in Critical Care
PEEP titration and variability in renal venous congestion metrics in mechanically ventilated patients Journal of Critical Care
Prognostic performance of the ratio of mean arterial pressure to norepinephrine equivalent dose in critically ill hypotensive patients: A single-center retrospective cohort study Journal of Critical Care
Prophylactic noninvasive ventilation after extubation in high-risk patients without hypercapnia Intensive Care Medicine
SOFA-2 score predicts mortality in pneumonia-associated sepsis: a retrospective cohort study Critical Care
Sustainable continuous renal replacement therapy: The influence of blood flow rates, effluent dose, autoeffluent, and citrate anticoagulation on carbon dioxide emissions Critical Care and Resuscitation
The Glasgow Coma Scale as a predictor of mortality in intensive care: relevance of underlying cause of impaired consciousness Journal of Critical Care
The Influence of Older Age on RBC Transfusion Decisions in ICU Patients Critical Care Medicine
The Triad of Dying: A framework for palliation and compassionate decision-making in the ICU Journal of the Intensive Care Society
Thoracic trauma in intensive care: A ten-year retrospective cohort study from a regional trauma unit Trauma
Transitions and determinants of ICU-acquired frailty after critical illness: A multicenter cohort study using a multistate Markov model Annals of Intensive Care
Using inability to walk to predict in-hospital mortality in a high-income country – A comparison with the National Early Warning Score in a multicenter prospective cohort Journal of Critical Care
Metadata
Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash
