Critical Care Evidence Updates – June 2026
Randomised Controlled Trials
Adjuvant intravenous immunoglobulin in elderly sepsis: a randomized controlled study of mortality, organ function, and inflammation Frontiers in Medicine
Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia NEJM
Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial Intensive Care Medicine
Endotracheal Tube Repositioning Frequency for Preventing Oral Mucosal Pressure Injuries in Intensive Care Units: A Randomised Controlled Trial Study Protocol Nursing in Critical Care
Enteral When Compared With IV Magnesium Replacement in the Critically Ill: A Noninferiority Randomized Clinical Trial Critical Care Medicine
Evaluation of the clinical impact of different telemedicine practices in intensive care units: A stepped-wedge cluster randomized clinical trial (TELESCOPE 2): Study protocol Critical Care and Resuscitation
HA-330 hemoadsorption in septic shock requiring high-dose norepinephrine: a multicenter randomized controlled trial (CLEANSE) Critical Care
Critical Care
Multidisciplinary telemedicine intervention for ICU recovery: the TelePORT feasibility randomized trial Critical Care
Nitrous oxide added at the end of sevoflurane anaesthesia hastens emergence and eliminates prolonged time to extubation (SEVONATE study): A randomised controlled trial Anaesthesia and Intensive Care
Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial Intensive Care Medicine
Pre-Emptive Initiation of Continuous Renal Replacement Therapy in Patients With Acute Liver Failure With Cerebral Edema Improves Outcomes: A Randomized Controlled Trial Alimentary Pharmacology and Therapeutics
Sugammadex versus neostigmine for reversal of neuromuscular blockade and postoperative pulmonary complications (SNaPP): an international, randomised, controlled, phase 4 trial The Lancet Respiratory Medicine
Swab Testing to Optimize Pneumonia Treatment With Empiric Vancomycin: A Randomized Controlled Trial Clinical Infectious Diseases
The cost analysis of remifentanil and fentanyl for analgosedation in mechanically ventilated patients in intensive care: Post hoc analysis of an open-labelled pilot randomised controlled study Critical Care and Resuscitation
Other Guidance/Reports
Ethical Considerations and End-of-Life Care in Donor and Transplant Critical Care Journal of Intensive Care Medicine
Guidelines: Diagnosis and management of perioperative immediate hypersensitivity reactions 2025 Anaesthesia Critical Care & Pain Medicine
International evidence-based recommendations for point-of-care lung ultrasound Intensive Care Medicine
Cochrane
Repositioning for pressure injury prevention in adults
Primary Research
A Retrospective Cohort Study Assessing the Impact of Dexmedetomidine on Prognosis in Mechanically Ventilated Sepsis Patients Journal of Intensive Care Medicine
Age-associated outcomes in cardiogenic shock supported with microaxial flow pumps Annals of Intensive Care
An exploration of the use of safety huddles in ICUs across the United Kingdom – A cross-sectional national e-survey Intensive and Critical Care Nursing
Arterial Blood Gas–Derived Risk Models for 28-Day Mortality in Critically Ill Adults: A Retrospective Cohort Study Journal of Intensive Care Medicine
Association Between Attending Physician Transition Days and Liberation from Mechanical Ventilation in the Intensive Care Unit Journal of Intensive Care Medicine
Association Between Emergency Department-to-ICU Transfer Time and Hospital Mortality Across ICU Admission Diagnoses: A Post Hoc Subgroup Analysis Critical Care Medicine
Association of obesity and nutritional status on early sepsis-associated acute kidney injury in older patients with sepsis BMC Nephrology
Body composition-guided protein dosing in critically ill patients: a before-and-after study (PROGRESS-ICU) Critical Care
Caring for Patients Receiving Continuous Renal Replacement Therapy in the Intensive Care Unit: A Qualitative Study Nursing in Critical Care
Determinants of Delayed Recovery of Consciousness After Analgosedation Discontinuation in the ICU: Insights From Patients With COVID-19 Hypoxemic Respiratory Failure Critical Care Medicine
Dexmedetomidine for Reducing Mortality in Patients with Sepsis and Concomitant Heart Failure: A Retrospective Cohort Study Journal of Intensive Care Medicine
Dietitian-Led Feeding Tube Placement: Reducing Nursing Workload and Enhancing Patient Safety in the Intensive Care Unit Critical Care Nurse
Does the Frailty Burden Impact ICU Performance Indicators Benchmarking? A Multicenter Cohort Study Using Two Severity-of-Illness Scores Critical Care Medicine
Early Corticosteroid use and Clinical Outcomes in Patients with Mixed and Cardiogenic Shock Journal of Intensive Care Medicine
Early identification of acute kidney injury progression in critically ill patients with sepsis: interpretable machine learning approach Clinical Kidney Journal
Effects of increasing respiratory rate on ventilatory efficiency and mechanical costs during low-tidal-volume ventilation: a prospective physiological pilot study Annals of Intensive Care
Evaluation of novel materials for front-of-neck access simulations Anaesthesia and Intensive Care
Facilitators and barriers to the implementation of critical care ultrasound (CCUS): an international survey Journal of Critical Care
Gut microbiota dysbiosis in intensive care unit patients with acute kidney injury: insights from 16S sequencing and mediation analysis BMC Nephrology
Human Development Index and outcomes in older critically ill patients: A European multicentre study Annals of Intensive Care
Identifying subgroups of ICU patients with high mortality rates using machine learning: A nationwide, population-based study Journal of Critical Care
Impact of higher versus lower PEEP on mortality in mechanically ventilated patients with Sepsis — A multicenter, multi-cohort observational analysis Journal of Critical Care
Impact of Molecular Adsorbent Recirculating System Therapy on Piperacillin Concentration in Critically Ill Patients: An Observational Cohort Study Critical Care Medicine
Implementation and evaluation of the multidisciplinary “ABCDEF of sleep” protocol in Brazilian intensive care units: A quasi-experimental study. Results of a two-phase Journal of Critical Care
Implementation of procalcitonin-guided antibiotic stopping advice in sepsis: A mixed-methods process evaluation in a clinical trial context Journal of the Intensive Care Society
Improved survival in patients admitted to ICU with multiple myeloma: a retrospective cohort analysis Annals of Intensive Care
Incidence and Outcomes of Refractory Septic Shock per Consensus Clinical Criteria: A Multicohort Retrospective Study Critical Care Medicine
Incidence of nasogastric tube-related pressure injury in the intensive care unit Journal of Wound Care
Intensive Care Nurses’ Experiences With Digital Silence and Implications for Care: A Qualitative Study Nursing in Critical Care
Interaction between healthcare professionals and the pediatric patient in an adult intensive care unit: An observational study Intensive and Critical Care Nursing
“It was torture for him, and it was torture for us to see him like that”: understanding multiple ICU-related triggers of family PTSD symptoms—a qualitative thematic study Intensive Care Medicine
Medical adhesive-related skin injury (MARSI) in intensive care: prevalence and associated factors Journal of Wound Care
Nursing Practice for Temperature Control During Continuous Kidney Replacement Therapy in Intensive Care: A Cross-Sectional Study Journal of Renal Care
Percutaneous dilatational tracheostomy and thyroid isthmus penetration (PETRIS) Anaesthesia Critical Care & Pain Medicine
Postoperative thermal comfort: Associations with pain, anxiety and body temperature Journal of Perioperative Practice
Prognosis of critically ill patients with cirrhosis and acute kidney injury initiated on dialysis BMC Nephrology
Prognostic factors in ICU patients with community-acquired bacterial meningitis: A post hoc analysis of a multicenter prospective cohort study Journal of Intensive Medicine
Progress of Severe AKI in Sepsis Patients Targeted by Iron Metabolism: A Retrospective Analysis of the MIMIC-IV Database Journal of Intensive Care Medicine
Promoting Sleep in Acute and Critically Ill Adults: Enhancing Recovery Through Evidence-Based Practices Critical Care Nurse
Psychology in an extracorporeal membrane oxygenation (ECMO) service in the North-West Journal of the Intensive Care Society
Pulse Pressure Variation During Passive Leg Raising to Assess Preload Responsiveness: Influence of Inspiratory Effort During Pressure Support Ventilation Critical Care Medicine
Radial Artery Catheter Complications Based on Site, Dressing and Application Technique: A Descriptive Observational Study Nursing in Critical Care
Reducing Respiratory Device–Related Pressure Injuries in High-Acuity Patients: A Quality Improvement Project Critical Care Nurse
Relationship between norepinephrine dose and outcome in septic shock: a retrospective study Journal of Anesthesia, Analgesia and Critical Care
Safer local anaesthetic practices through multidisciplinary engagement: A pre–post intervention study Journal of Perioperative Practice
SOFA-2 Versus SOFA-1 for Mortality Prediction in Infection-Triggered ICU Patients Journal of Intensive Care Medicine
Standardized low-flow ventilation with PEEP maintenance during bronchoscopy in mechanically ventilated ICU patients: a pilot trial Journal of Intensive Care
Status Epilepticus Is Detected Earlier than Seizures on cEEG in Critically Ill Adults Neurocritical Care
The Impact of Centrally Acting Drug Burden at Discharge on Long-Term Outcomes Among ICU Survivors Critical Care Medicine
The interplay between microcirculatory dysfunction and coagulopathy in patients with sepsis: An exploratory single-center observational study Journal of Critical Care
The thyroid-heart axis-hormone dynamics and outcomes in cardiogenic shock following myocardial infarction Journal of the Intensive Care Society
The use of the modified Dutch worry criteria, combined with vital signs and early warning scores, to improve nurses’ recognition and escalation of ward deteriorating patients: A prospective cross-sectional observation multi-method study Intensive and Critical Care Nursing
Timing matters: sex differences in treatment limitation decisions in intensive care Critical Care
Ventilator-associated pneumonia in males and females: A post hoc analysis of the prospective multicenter multinational EUVAP cohort Journal of Intensive Medicine
Metadata
Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash
