Critical Care Evidence Updates – July 2026

Randomised Controlled Trials

Bayesian analysis of the early cold stored platelet transfusion following severe injury randomized clinical trial  Trauma Surgery & Acute Care Open

Dapagliflozin and Acute Kidney Injury Following Cardiac SurgeryA Randomized Clinical Trial  JAMA

Dapagliflozin in acute myocardial infarction with type 2 diabetes: a randomized clinical trial  Current Problems in Cardiology

Early Nephrology Consultation and Acute Kidney Injury in Hospitalized Patients – A Randomized Clinical Trial  JAMA Network Open

Effects of Abdominal Electrical Stimulation Combined With Airway Clearance Techniques in Tracheotomized Patients With Neurological Disorders: A Randomized, Controlled Trial  Critical Care Medicine

Facilitating Communication for Family Members of Critically Ill Patients During and Following a Hospital Stay: A Randomized Controlled Trial  Critical Care Medicine

ICU-specific virtual reality for mental health after critical illness: an international three-arm randomized clinical trial  Critical Care

Impact of ultra-low tidal volume ventilation on 1-year functional outcome in COVID-19 ARDS patients. A long-term follow-up analysis of a randomized controlled trial  Critical Care

Remimazolam Versus Midazolam for Sedation in Mechanically Ventilated Patients with Severe Pneumonia: A Randomized Controlled Trial  Journal of Intensive Care Medicine

Standard-dose unfractionated heparin versus low-dose unfractionated heparin and low-molecular-weight heparin in extracorporeal life support (RATE): an open-label, randomised, non-inferiority trial  The Lancet

Temocillin versus carbapenems for bacteraemia due to third-generation cephalosporin-resistant Enterobacterales in Spain (ASTARTÉ): a multicentre, phase 3, open-label, non-inferiority, randomised clinical trial  The Lancet

Vasopressin-Based Versus Norepinephrine-Based Strategy in Vasoplegic Syndrome After Cardiac Surgery: A Randomized Controlled Trial  Journal of Intensive Care Medicine

YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism in Patients With Cancer – A Randomized Clinical Trial  JAMA

 

Other Guidance/Reports

2026 ESAIC Consensus Document on Mitigation Strategies in Intensive Care Medicine  European Journal of Anaesthesiology

Consensus recommendations for patient selection and clinical implementation of polymyxin B hemoadsorption in endotoxic septic shock  Critical Care

Core outcome set for trials evaluating the management of community-acquired and nosocomial pneumonia in adults: an ERS statement  European Respiratory Journal

Developing a comprehensive haemodynamic ultrasound assessment for critical care: Rationale and methodology from the FUSIC programme  Journal of the Intensive Care Society

Digital biomarkers in cardiovascular medicine: a scientific statement of the ESC Working Group on e-Cardiology, the ESC Working Group on Cardiovascular Pharmacotherapy, the European Heart Rhythm Association (EHRA) of the ESC, the Association for Acute Cardiovascular Care (ACVC) of the ESC, the Heart Failure Association (HFA) of the ESC, the European Association of Preventive Cardiology (EAPC) of the ESC, the European Association of Cardiovascular Imaging (EACVI) of the ESC, in collaboration with the Digital Cardiology and Artificial Intelligence Committee of the ESC, and the ESC Regulatory Affairs Committee  European Heart Journal

Ethical Implementation of Organ Donation Following Medical Assistance in Dying: Recommendations of the Ethics Committee of the Transplantation Society  Transplantation

Explosive Weapons Trauma Care Collective (EXTRACCT) Clinical Practice Guideline: Transfer of Critically Injured Casualties  World Journal of Surgery

Management of critically ill cancer patients. Expert consensus statement of the “Intensive Care for Hematology and Oncology Patients” (iCHOP) Working Group of the German Society of Hematology and Oncology (DGHO), Austrian Society of Hematology and Oncology (OeGHO), German Society for Medical Intensive Care Medicine and Emergency Medicine (DGIIN), and Austrian Society of Medical and General Intensive Care and Emergency Medicine (ÖGIAIN)  European Journal of Cancer

Meningitis, encephalitis, and beyond: A practical intensive care unit guide to severe central nervous system infections  Journal of Intensive Medicine

Strategies to prevent ventilator-associated pneumonia in critically ill mechanically ventilated patients: a SIAARTI consensus statement  Journal of Anesthesia, Analgesia and Critical Care

Updated consensus terminology and definitions in chest electrical impedance tomography  IPEM

Usefulness of Bedside Point-of-care Ultrasounds in Intensive Care Unit for Septic Patients: A Consensus Statement of the Italian Society of Echocardiography and Cardiovascular Imaging  Journal of Cardiovascular Echography

Primary Research

A multiprofessional intervention for patients at risk of physical and psychological problems after ICU stay: A feasibility study  Intensive and Critical Care Nursing

A Qualitative Multicenter Study of Participant Experiences With an App-Based Mindfulness Intervention (Lift 2) for Critical Illness Survivors  Critical Care Explorations

Adenosine 5′-monophosphate prevents sepsis-associated muscle wasting by activating AMPK and suppressing IL-1β inflammatory cytokines  Journal of Intensive Care

Alarm configuration and adherence to prescribed mean arterial pressure targets in the intensive care unit: A multicentre pre–post evaluation  Critical Care and Resuscitation

Association Between the Hemoglobin-to-Red Blood Cell Distribution Width Ratio and Perioperative Mortality Risk in Myasthenia Gravis Patients with Sepsis: A Retrospective Cohort Study  Journal of Intensive Care Medicine

Association of esketamine exposure with secondary sclerosing cholangitis in critically ill patients: a retrospective cohort analysis of 20,000 ICU cases  Journal of Intensive Care

Association of prolonged pre-intubation high-flow nasal cannula duration with survival and successful V-V ECMO liberation in severe ARDS: a retrospective multicenter study  Journal of Intensive Care

Carotid blowout with ‘can’t intubate, can’t oxygenate’ crisis: Supraglottic surgical airway rescue  Anaesthesia and Intensive Care

Case Series: Episodes of Care in an Intensive Care Garden—Does Fresh Air Matter?  Nursing in Critical Care

Characteristics and outcomes of intensive care patients receiving metaraminol infusion—a retrospective observational cohort study  Anaesthesia and Intensive Care

Clinical and Culture-Based Predictors of Gut Microbiome Alpha Diversity at the Time of ICU Admission  Critical Care Explorations

Comparison of the Feasibility of Respiratory Exercises in Postoperative Patients: An Intensive Care Study  Nursing in Critical Care

Critical Care Aggression and Violence Events (CAVE) Against Nurses in the ICU: Epidemiology and Risk Factors for Recurrence  Critical Care Medicine

Early red blood cell transfusion burden, hemoglobin at first transfusion, and in-hospital mortality in patients supported with veno-arterial ECMO: a multicenter cohort study  Annals of Intensive Care

Echocardiographic assessment of left ventricular longitudinal function in critically ill patients  Critical Care

Effects of direct tracheostomy on ventilator weaning in patients intubated for Guillain-Barré syndrome  Annals of Intensive Care

Extracorporeal circuit temperature gradient and hemodynamic instability during continuous renal replacement therapy: an observational study  Annals of Intensive Care

Factors influencing the acceptability of remote multicomponent rehabilitation versus standard care following critical illness: a theory-informed qualitative study embedded within the iRehab trial  Journal of Intensive Care

Faster administration of antimicrobials in sepsis team quality improvement initiative in the intensive care unit: a retrospective audit (FAAST-R)  International Journal of Pharmacy Practice

Genomic dynamics of antimicrobial resistance transmission between bacteria from intensive care unit surfaces and from critically ill patients  Critical Care

Greening critical care by harnessing the planetary impact of medications: What fellows need to know  Journal of Critical Care

Health-Economic Value of Transvenous Diaphragm Neurostimulation in Ventilator Weaning  Critical Care Medicine

High-resolution monitoring reveals fragmented 24-hour light exposure in intensive care units  Critical Care

Hormone replacement before brain death increases organ donation rate after catastrophic brain injury: An EAST multicenter trial  Journal of Trauma and Acute Care Surgery

Hospital ward transitions and outcomes in critical care survivors: A multi-hospital cohort study  Journal of the Intensive Care Society

ICU-acquired acute kidney injury in critically ill adults: a retrospective cohort study of risk factors and KDIGO stage dynamics in a Brazilian ICU  Renal Failure

Impact of Intubation Location on Deep Sedation in the First 24 Hours of Medical ICU Care  Journal of Intensive Care Medicine

Immunocompromised patients with viral severe acute respiratory infection in intensive care: an Australia wide, retrospective, observational study  Critical Care

In-hospital development of new-onset frailty and discharge outcomes among patients with sepsis: a Korean multicenter registry study  Journal of Intensive Care

Knowledge, attitudes, and behaviors questionnaire on environmental sustainability in intensive care unit (KABQES-ICU): Validity and reliability study  Intensive and Critical Care Nursing

Mucormycosis in critically ill patients: a 9-year multicenter cohort study of clinical features, management, and 90-day outcomes  Critical Care

Nutrition and Exercise in Critical Illness (NEXIS) trial: randomized trial of combined in-bed cycling and intravenous amino acid plus usual care  AJRCCM

Persistent tissue hypoperfusion improves risk stratification beyond vasopressor dose in refractory septic shock: a secondary analysis of the ANDROMEDA-SHOCK-2 trial  Intensive Care Medicine

Pre-ICU hospital length of stay and 30-day mortality in the very old: a national cohort of 315 042 ICU admissions  Annals of Intensive Care

Previous-day physical restraint duration as a bedside signal for following-day delirium: a retrospective patient-day analysis in a mixed ICU  Journal of Intensive Care

Procalcitonin kinetics in critically ill patients: a retrospective analysis of the impact of renal dysfunction and renal replacement therapy  Journal of Anesthesia, Analgesia and Critical Care

Proenkephalin A for assessing kidney integrity and guiding KRT liberation decisions in critically ill patients  Annals of Intensive Care

Psychometric Properties of the Patient Dignity Inventory in a Longitudinal Cohort of Acute Respiratory Failure Survivors  Critical Care Medicine

Safety and outcomes of dapagliflozin initiation in critically ill patients with acute kidney injury: A post-hoc analysis of the defender trial  Journal of Critical Care

Secondary Atrial Fibrillation in Critically Ill Sepsis Patients: Evaluating the Role of Early Oral Anticoagulants in a Retrospective Multi-Center Study  Journal of Intensive Care Medicine

Surgical site infection incidence and surgical antibiotic prophylaxis in the ICU patient: a multicenter observational study  Journal of Intensive Care

The Development, Acceptability and Suitability of an Information and Well-Being Booklet for Family Members of Intensive Care Unit Patients  Nursing in Critical Care

The effect of initial rhythm on patient outcome in refractory cardiac arrest requiring extracorporeal cardiopulmonary resuscitation: A retrospective, multicentre registry cohort study  Critical Care and Resuscitation

The impact of physiotherapy led lung ultrasound on patient management: A single centre service evaluation  Journal of the Intensive Care Society

The Nonlinear Impact of Cumulative Fluid Balance on Severe Acute Kidney Injury During the First Three ICU Days in Sepsis  Journal of Intensive Care Medicine

The Unseen Wounds of Intensive Care: A Mixed Methods Study of Nurses’ Exposure to Violence  Nursing in Critical Care

Towards a Conceptual Definition of ICU-Acquired Oral Frailty: A Qualitative Study of Patients, Family Members and Clinicians  Nursing in Critical Care

Troponin T clearance via continuous renal replacement therapies in the ICU  Journal of Intensive Care

Venous congestion in critical care: Combining VExUS, lung ultrasound, and echocardiography  Annals of Intensive Care

Volatile sedation using isoflurane versus intravenous sedation in intensive care unit: a propensity matched case control study  Annals of Intensive Care

 

Metadata

Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash