PEITHO
In patients with intermediate-risk/sub-massive pulmonary embolism (PE), does the addition of tenecteplase, compared with heparin alone improve the composite outcome of death and haemodynamic decompensation?
Continue reading »Author: David Slessor
MOPETT
In patients with moderate Pulmonary Embolism (PE), does low dose thrombolysis + anticoagulation, compared with anticoagulation alone, reduce pulmonary artery pressure at 28 months?
Continue reading »MAPPETT 3
In patients with sub-massive PE, does the use of thrombolysis + heparin, compared to heparin alone, reduce the composite outcome of mortality or clinical deterioration?
Continue reading »SEPSISPAM
In patients with septic shock does a high target mean arterial pressure (MAP), compared to a low target MAP, improve mortality?
Continue reading »Than
In patients with suspected acute coronary syndrome does a rapid diagnostic pathway allow early discharge from hospital without more adverse effects when compared with a conventional diagnostic assessment and discharge plan?
Continue reading »OSCILLATE
Does High Frequency Oscillatory Ventilation (HFOV) improve mortality in patients with new onset moderate-severe ARDS compared with standard ventilation?
Continue reading »Waldman
In patients with corneal abrasions, is topical tetracaine, compared with saline, for 24 hours a safe and effective analgesic?
Continue reading »OSCAR
Does High Frequency Oscillatory Ventilation (HFOV), compared with conventional ventilation, improve 30 day mortality in patients with ARDS?
Continue reading »Jacobs
In patients with cardiac arrest does adrenaline, compared to placebo, improve survival to hospital discharge?
Continue reading »Villanueva
In patients who present with an upper gastrointestinal (GI) bleed, does a restrictive transfusion goal compared with a liberal transfusion goal affect mortality?
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