Jake Reeve

LOGICAL – Conservative Oxygen after Cardiac Arrest

Conservative Oxygen for Unresponsive Patients after Cardiac Arrest The LOGICAL Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. NEJM. 2026. doi: 10.1056/NEJMoa2513814 Clinical Question In patients who are unresponsive after cardiac arrest, does limiting oxygen exposure to achieve acceptable oxygenation increase the likelihood of surviving with a favourable functional outcome Background Brain damage and unfavourable […]

Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery

28 November 2025 Jake Reeve Peri-operative Medicine Leave a comment

Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery: The IMPROVE-multi Randomized Clinical Trial B Saugel. JAMA 2025; doi: 10.1001/jama.2025.17235 Clinical Question In patients undergoing major intra-abdominal surgery, does an individualised blood pressure target, compared to standard care, improve rates of acute kidney injury, acute myocardial infarction, non-fatal cardiac arrest or death within the first 7 days? Background […]