PREPARE II

Effect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation @DerekRussellMD. JAMA; 328(3):270-279. doi:10.1001/jama.2022.9792 Clinical Question In critically ill adult patients undergoing tracheal intubation and positive pressure ventilation, does intravenous infusion of a 500ml fluid bolus vs no fluid bolus, decrease the incidence of cardiovascular collapse during, or shortly after the procedure? Background Tracheal intubation […]

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PILOT

Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation Semler. N Engl J Med 2022; 387:1759-1769. DOI: 10.1056/NEJMoa2208415 Clinical Question In patients receiving invasive mechanical ventilation, does a target oxygen saturation of 90%, 94%, or 98% increase days alive and free of mechanical ventilation at 28 days? Background Despite the ubiquity of oxygen therapy in the critical care setting, the […]

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