Critical Care Evidence Updates – January 2026
Randomised Controlled Trials
Early Supplemental Parenteral Nutrition Shortens Ventilation and Intensive Care Unit Stay in ICU Patients Aged ≥60 Years Requiring Mechanical Ventilation: A Randomized Controlled Trial Clinical Nutrition ESPEN
Efficacy and safety of remimazolam besylate in patients receiving mechanical ventilation: A randomized phase Ⅱa trial Journal of Intensive Medicine
Impact of renal vein doppler ultrasound-guided CVP titration in sepsis: a pilot randomized controlled trial Critical Care
Remimazolam Besylate Versus Dexmedetomidine As a Sedative in ICU Patients Undergoing Mechanical Ventilation: A Multicenter, Single-blinded, Randomized, Noninferiority Trial Critical Care Medicine
Other Guidance/Reports
A consensus of international experts on definition, sampling, treatment, and prevention of peripheral extracorporeal membrane oxygenation cannula-site infection obtained by the Delphi method: the SAVECMO study Intensive Care Medicine
Consensus document on the diagnosis and treatment of acute kidney injury Nefrologia (English edition)
Consensus Statement on Optimisation of Patient Care After Hospitalisation for Acute Heart Failure Heart, Lung and Circulation
Dead space in critical care: a practical approach with clinical scenarios Journal of Anesthesia, Analgesia and Critical Care
Guidelines for Neuroprognostication in Critically Ill Adults with Status Epilepticus Neurocritical Care
JSA guideline for management of malignant hyperthermia in 2025 Journal of Anesthesia
Multidisciplinary guidelines on renal replacement therapy in intensive care medicine Critical Care
Practice guideline on the prevention and treatment of central line-associated bloodstream infection: Part 1––Diagnosis and prevention Journal of Intensive Medicine
Practice guideline on the prevention and treatment of central line-associated bloodstream infection: Part 2 – Treatment Journal of Intensive Medicine
Standardization of Baseline and Provocative Invasive Hemodynamic Protocols for the Evaluation of Heart Failure and Pulmonary Hypertension: A Scientific Statement From the American Heart Association Circulation: Heart Failure
Primary Research
A national benchmarking survey to explore the use of dose error reduction software in adult intensive care units (ICUs) Journal of the Intensive Care Society
Acute kidney injury is a major mediator of intra-abdominal pressure-related mortality in critically ill patients: a longitudinal analysis Journal of Anesthesia, Analgesia and Critical Care
An episode-based approach for assessing the impact of dyskalaemia on critical care outcomes – results from a territory-wide cohort study Anaesthesia and Intensive Care
Bedside detection of end-tidal overdistention: an exploratory comparison of loading maneuvers Intensive Care Medicine Experimental
Between a nightmare and a miracle: A qualitative study of patient experience during and after intensive care unit admission in pregnancy or postpartum Journal of Critical Care
Can one use serum Lactate Concentration to Correct for the Anion gap? Journal of Intensive Care Medicine
Clinicians’ Perspectives on Strengthening Interprofessional Teamwork to Support Surrogate Decision-Makers of Critically Ill Patients in ICUs Critical Care Explorations
Comparison of prolonged exhalation end-tidal CO₂ and transcutaneous CO₂ monitoring in COPD patients Critical Care
Development and external validation of a machine learning model for predicting the 28-day mortality risk in patients with sepsis complicated by acute respiratory failure in the ICU Journal of Intensive Medicine
Effect of Neurologic Conditions on Delirium Duration and Time to ICU Discharge Critical Care Explorations
Epidemiology and outcome of intra-abdominal infections in intensive care unit in Italy from the Italian Register of complicated Intra-abdominal InfectionS—the IRIS study: a prospective observational nationwide study Journal of Anesthesia, Analgesia and Critical Care
Evaluation of Clonidine Utilization for Dexmedetomidine Discontinuation in the Intensive Care Unit Journal of Intensive Care Medicine
Exploring the training, implementation and utilisation experiences of lung ultrasound accredited physiotherapists in the United Kingdom: A national survey Journal of the Intensive Care Society
Family-administered delirium screening improves satisfaction among ICU caregivers: a prospective cohort study Intensive Care Medicine
Guideline-Concordant Sedative and Analgesia Use in Critically Ill Patients Receiving Sustained Neuromuscular Blockade Critical Care Explorations
Impaired systemic antibody response against gut microbiota pathobionts in critical illness and susceptibility to nosocomial infections Intensive Care Medicine Experimental
Infection-related hospital readmissions after surviving sepsis: A retrospective population level study of adult sepsis survivors in Australia Journal of Critical Care
Inhaled L-Epinephrine As a Rescue Therapy in Critical Bronchiolitis Critical Care Explorations
MELD-Lactate and lactate clearance in critically ill cirrhosis patients with sepsis The American Journal of Gastroenterology
Monitoring respiratory effort during invasive mechanical ventilation: a multinational survey of clinical practice Intensive Care Medicine
Morphological subphenotypes of acute pancreatitis-related acute respiratory distress syndrome Critical Care
Passive leg raising and microvascular skin blood flow to predict peripheral tissue perfusion fluid responsiveness Critical Care
Patterns of opioid and sedative use in adult ICUs: Insights from the ALERT-ICU study on iatrogenic withdrawal syndrome Journal of Critical Care
Real-time prediction of ventilator-associated pneumonia onset in ICU: development of a dynamic machine learning model Journal of Anesthesia, Analgesia and Critical Care
Risk Factors Associated with the Onset of Atrial Fibrillation in Patients with Sepsis and Septic Shock in Intensive Care Units Journal of Intensive Care Medicine
Self-Efficacy and Knowledge of Intensive Care Nurses in the Management of Pressure Injuries The Journal of Continuing Education in Nursing
The effect of dexmedetomidine on rocuronium-induced neuromuscular blockade and its reversal by sugammadex Intensive Care Medicine Experimental
The impact of early physical mobilisation for the management and prevention of intensive care unit delirium: A qualitative study exploring patients’ perspectives Journal of the Intensive Care Society
The impact of ketamine on ICU mortality in patients with sepsis: A retrospective cohort study Journal of Critical Care
The Relationship Between Lactate Levels and Acute Kidney Injury Risk in Patients with Hemorrhagic Shock and Septic Shock: An Analysis Based on the MIMIC-IV Database Journal of Intensive Care Medicine
The SIS NET ICU study: characteristics of patients with severe community acquired pneumonia admitted to Italian ICUs—a multicenter prospective observational study Journal of Anesthesia, Analgesia and Critical Care
The Superiority of AVAPS Mode of Non-invasive Ventilation in Combination with HFNC Over HFNC Alone in Patients with Chronic Obstructive Pulmonary Disease Complicated by Respiratory Failure Journal of Intensive Care Medicine
The Use of Vasoactive Agents in Pulmonary Embolism Among the Critically Ill: A Multi-Centred, Retrospective Cohort Study in Queensland Intensive Care Units Journal of Intensive Care Medicine
Thermal intervention improves pulse oximetry accuracy in critically ill patients with low perfusion: a quasi-experimental study Journal of Intensive Care
Validation of SOFA-2 score in sepsis and exploration of its extension with additional immune markers Journal of Intensive Medicine
Validity of ICU prognostic risk stratification tools in the oldest patients: a comparative analysis of clinical scores in a multicenter binational cohort Journal of Anesthesia, Analgesia and Critical Care
Metadata
Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash
