Category: Blog

ACTiVE – Automated Closed-Loop Ventilation vs Protocolized Conventional Ventilation

Evidence-based Medicine, Intensive Care Medicine Leave a comment

Effect of Automated Closed-Loop Ventilation vs Protocolized Conventional Ventilation on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial Sinnige J. JAMA 2025. doi:10.1001/jama.2025.24384 Clinical Question Among critically ill mechanically ventilated adults, does early use of an automated closed-loop ventilation system (INTELLiVENT-ASV) increase ventilator-free days at day 28 (VFD-28) compared with protocolled conventional ventilation (CV)? Background Mechanical ventilation carries […]

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ANDROMEDA-SHOCK2 – Personalized Hemodynamic Resuscitation

Evidence-based Medicine, Intensive Care Medicine Leave a comment

Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock ANDROMEDA SHOCK 2 Investigators @ShockAndromeda2. JAMA 2025. doi:10.1001/jama.2025.20402 Clinical Question In adult patients with early septic shock, does a personalised haemodynamic resuscitation protocol targeting capillary refill time (CRT) normalisation improve outcomes compared to usual care? Background In septic shock, the pathophysiological mechanisms contributing to the development of a shocked […]

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