Tag: Peri-operative Medicine

TOP: Liberal or restrictive post-op transfusion

Liberal or Restrictive Postoperative Transfusion in Patients at High Cardiac Risk: The TOP Randomized Clinical Trial Kougias P. JAMA 2025;334:2197-2207. doi:10.1001/jama.2025.20841 Clinical Question In high cardiac risk adults who develop postoperative anaemia following vascular or general surgery, does a liberal transfusion threshold (Hb <10 g/dL) compared to a restrictive transfusion threshold (Hb <7 g/dL) reduce 90‑day incidence of all‑cause death, […]

BigPAK-2 – preventive care strategy to reduce acute kidney injury after major surgery

A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial Zarbock. The Lancet 2025. doi: 10.1016/S0140-6736(25)01717-9 Clinical Question In patients at high risk of AKI undergoing major surgery, does a preventative care strategy based on KDIGO guidelines, compared to standard care lead to a reduction in moderate/severe AKI within […]