A compendium of critical appraisals in Intensive Care Medicine research and related specialties
Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH – 3): a randomised, placebo-controlled trial The CRASH-3 trial collaborators. The Lancet, 2019; doi.org/10.1016/S1040-6736(19)32233-0 Clinical Question In patients with traumatic brain injury (TBI), does the administration of tranexamic acid (TXA) under 3 hours from injury, compared with placebo, reduce […]
Continue reading »
In adult patients with sepsis-associated coagulopathy does the administration of human recombinant thrombomodulin (rhsTM) compared to placebo reduce 28 day mortality?
Continue reading »
In adults with acute, spontaneous intra-cerebral haemorrhage (ICH), does the administration of tranexamic acid (TXA) compared to a placebo improve functional status at 90 days?
Continue reading »
In adult patients with out-of-hospital cardiac arrest (OOHCA), does the administration of epinephrine compared to placebo improve survival?
Continue reading »
In adult patients post out of hospital cardiac arrest does a continuous or on demand application of neuromuscular blockade (NMB) reduce the number of shivering episodes during targeted temperature management (TTM)?
Continue reading »
In adult patients undergoing elective coronary-artery surgery does tranexamic acid (TXA) compared to a placebo increase the risk of death or thrombotic complications within the first 30 days after surgery?
Continue reading »
In adults undergoing elective coronary artery graft surgery does the administration of aspirin prior to surgery compared to a placebo result in increased mortality or thrombotic complications?
Continue reading »