George Walker

TIGHT K: Potassium Supplementation and Prevention of Atrial Fibrillation After Cardiac Surgery

Potassium Supplementation and Prevention of Atrial Fibrillation After Cardiac Surgery: The TIGHT K Randomized Clinical Trial O’Brien. JAMA 2024; 332:979 – 988. doi:10.1001/jama.2024.17888 Clinical Question In adult patients undergoing coronary artery bypass surgery (CABG) is supplementing potassium when serum concentration is ≤ 3.5 mEq/L non-inferior to supplementation when serum concentration is ≤ 4.5 mEq/L to reduce the frequency of new […]

ANNEXA-I – Andexanet for Factor Xa Inhibitor–Associated ICH

In patients who have recently taken factor Xa inhibitors with an intracerebral haemorrhage (ICH) did the administration of Andexanet result in better haemostatic efficacy compared to standard care?

DanGer Shock – Microaxial Flow Pump in Infarct-Related Cardiogenic Shock

26 April 2024 George Walker Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock Møller JE et al. 2024. NEJM. DOI: 10.1056/NEJMoa2312572 Clinical Question In adults presenting with STEMI and cardiogenic shock does the use of a microaxial flow pump (Impella CP) compared to standard care reduce death from any cause at day 180? Background Cardiogenic shock is a frequent complication of STEMI and […]

ACORN

10 January 2024 George Walker Emergency Medicine, Intensive Care Medicine Leave a comment

In acutely ill adults (ED / ICU) does the administration of cefipime or piperacillin-tazobactam (pip-taz) result in an increased incidence of AKI or death by day 14?

STRESS-L: Landiolol and Organ Failure in Patients With Septic Shock

29 October 2023 George Walker Intensive Care Medicine, Summaries Leave a comment

Landiolol and Organ Failure in Patients With Septic Shock Whitehouse. JAMA Published online October 25, 2023. doi:10.1001/jama.2023.20134 Clinical Question In patients with tachycardia and septic shock who are treated with high dose norepinephrine does the use of β-blockade for up to 14 days reduce organ failure compared to standard care? Background Many view the use of β-blockade as contentious in […]

Acetazolamide in Acute Decompensated Heart Failure with Volume Overload

4 August 2023 George Walker Intensive Care Medicine, Summaries Leave a comment

In adult patients with acute decompensated heart failure (ADHF), does the addition of acetazolamide to loop diuretics improve decongestion by day 3?

Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia

28 July 2023 George Walker Evidence-based Medicine, Intensive Care Medicine Leave a comment

In haematology or ICU patients with platelet counts between 10,000 and 50,000 per mm3, is receiving no prophylactic platelets non inferior compared to the administration of 1u platelets in order to reduce the risk of catheter-related bleeding?

DEVICE

1 July 2023 George Walker Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

In critically ill adults undergoing tracheal intubation, does the use of a videolaryngoscope (VL) compared to a direct laryngoscope (DL) improve the first-pass success rate?

TAME

19 June 2023 George Walker Evidence-based Medicine, Intensive Care Medicine Leave a comment

In patients resuscitated from out-of-hospital cardiac arrest (OOHCA) does targeted mild hypercapnia compared to targeted normocapnia improve 6-month neurological outcomes?

CAPE COD

22 March 2023 George Walker Intensive Care Medicine, Summaries Leave a comment

In patients with severe community acquired pneumonia (CAP) does the use of hydrocortisone compared to a placebo reduce 28-day mortality?

1 2 3 … 5 »