George Walker

STRESS-L: Landiolol and Organ Failure in Patients With Septic Shock

29 October 2023 George Walker Intensive Care Medicine, Summaries Leave a comment

Landiolol and Organ Failure in Patients With Septic Shock Whitehouse. JAMA Published online October 25, 2023. doi:10.1001/jama.2023.20134 Clinical Question In patients with tachycardia and septic shock who are treated with high dose norepinephrine does the use of β-blockade for up to 14 days reduce organ failure compared to standard care? Background Many view the use of β-blockade as contentious in […]

Acetazolamide in Acute Decompensated Heart Failure with Volume Overload

4 August 2023 George Walker Intensive Care Medicine, Summaries Leave a comment

In adult patients with acute decompensated heart failure (ADHF), does the addition of acetazolamide to loop diuretics improve decongestion by day 3?

Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia

28 July 2023 George Walker Evidence-based Medicine, Intensive Care Medicine Leave a comment

In haematology or ICU patients with platelet counts between 10,000 and 50,000 per mm3, is receiving no prophylactic platelets non inferior compared to the administration of 1u platelets in order to reduce the risk of catheter-related bleeding?

DEVICE

1 July 2023 George Walker Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

In critically ill adults undergoing tracheal intubation, does the use of a videolaryngoscope (VL) compared to a direct laryngoscope (DL) improve the first-pass success rate?

TAME

19 June 2023 George Walker Evidence-based Medicine, Intensive Care Medicine Leave a comment

In patients resuscitated from out-of-hospital cardiac arrest (OOHCA) does targeted mild hypercapnia compared to targeted normocapnia improve 6-month neurological outcomes?

CAPE COD

22 March 2023 George Walker Intensive Care Medicine, Summaries Leave a comment

In patients with severe community acquired pneumonia (CAP) does the use of hydrocortisone compared to a placebo reduce 28-day mortality?

CLOVERS

27 January 2023 George Walker Emergency Medicine, Intensive Care Medicine Leave a comment

In patients with sepsis-induced hypotension does a restrictive fluid strategy (with early vasopressor usage) compared to a liberal fluid strategy result in lower mortality before discharge by day 90?

Pro-MEDIC

19 December 2022 George Walker Intensive Care Medicine Leave a comment

In adults with an expected ICU stay of > 72 hours, does the provision of enteral melatonin compared to placebo increase the number of delirium-free assessments within 14 days or before ICU discharge?

TEAM

9 December 2022 George Walker Intensive Care Medicine, Summaries Leave a comment

Early Active Mobilization during Mechanical Ventilation in the ICU @chodgsonANZICRC @TEAMtrialICU. NEJM 2022; 387:1747-58 doi:10.1056/NEJMoa2209083 Clinical Question In mechanically ventilated adult patients does the provision of early mobilisation when compared to standard care increase the number of days alive and out of hospital at 180 days? Background ICU Acquired weakness (ICUAW) is common with one systematic review reporting a median […]

TBL Mini: Rib Fixation

14 November 2022 George Walker Intensive Care Medicine, Summaries Leave a comment

Operative vs Nonoperative Treatment of Acute Unstable Chest Wall Injuries: A Randomised Clinical Trial Dehghan et al. JAMA Surg 2022 doi:10.1001/jamasurg.2022.4299 Background Blunt chest wall trauma has high associated rates of morbidity and mortality RCTs have shown a reduced ICU length of stay in those requiring mechanical ventilation, however this has not been replicated in non-ventilated patients What did they […]

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