Critical Care Evidence Updates – August 2025
What’s new in the Critical Care literature – monthly updates
Continue reading »Year: 2025
Emergency Evidence Updates – August 2025
What’s new in the Critical Care literature – monthly updates
Continue reading »Collaborative VLS – Video vs Direct Laryngoscopy for Endotracheal Intubation in the OT
Video Laryngoscopy vs Direct Laryngoscopy for Endotracheal Intubation in the Operating Room A Cluster Randomized Clinical Trial Ruetzler et al. JAMA 2024;331;(15):1279-1286. doi:10.1001/jama.2024.0762 Clinical Question In patients being intubated for cardiac, thoracic or vascular surgery, does initial video laryngoscopy (VL) with a hyperangulated blade or direct laryngoscopy (DL) effect the number of intubation attempts? Background Endotracheal intubation is integral to the […]
Continue reading »REMAP CAP: Corticosteroids
Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia: The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial Angus. ICM 2025; doi: https://doi.org/10.1007/s00134-025-07861-w Clinical Question In adult patients with severe community acquired pneumonia (CAP) requiring ICU admission, does a 7-day course of intravenous hydrocortisone reduce 90-day mortality? Background Community-acquired pneumonia (CAP) remains a leading cause of ICU admissions and mortality […]
Continue reading »Target Protein – Augmented Enteral Protein During Critical Illness
Augmented Enteral Protein During Critical Illness MJ Summers. JAMA 2025; doi: 10.1001/jama.2025.9110 Clinical Question In critically ill patients receiving enteral nutrition does the augmentation of protein delivery compared to standard care result in an increased number of days free of the index hospital and alive at day 90? Background Critical illness weakness is a common complication within the ICU population […]
Continue reading »Shared Decision Making in Resuscitation Decisions
A Randomized Trial of Shared Decision-Making in Code Status Discussions Becker. NEJM Evidence 2025; doi:10.1056/EVIDoa2400422 Clinical Question In hospitalized adults requiring code status discussions, does a shared decision-making approach (including a checklist and decision aid) compared to usual care increase the proportion of patients choosing a DNR status? Background In-hospital cardiac arrest outcomes are poor (<20% survival; ~40% with neurologic […]
Continue reading »UK-ROX Trial
Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients Martin. JAMA June 12 2025; doi:10.1001/jama.2025.9663 Clinical Question In mechanically ventilated adult patients in the ICU, does a strategy of conservative oxygen therapy, targeting a SpO2 of 90% (Range 88-92%) compared with usual care, reduce mortality at 90 days? Background In the United Kingdom, around 184,000 adults are admitted to […]
Continue reading »Critical Care Evidence Updates – May 2025
What’s new in the Critical Care literature – monthly updates
Continue reading »Emergency Evidence Updates – May 2025
What’s new in the Critical Care literature – monthly updates
Continue reading »Fluid – Hospital Wide Lactated Ringer’s versus Normal Saline
A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline L McIntyre. NEJM 2025; DOI: 10.1056/NEJMoa2416761 Clinical Question In hospitalised patients, does the use of Lactated Ringers (LR) vs Normal Saline (NS) lower the incidence of death or readmission to the hospital within 90 days after the index admission? Background Fluid choice (balanced solutions vs NS) has been widely […]
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