Critical Care Evidence Updates – February 2025
What’s new in the Critical Care literature – monthly updates
Continue reading »Year: 2025
Emergency Evidence Updates – February 2025
What’s new in the Critical Care literature – monthly updates
Continue reading »NAVIGATE: Early noninvasive ventilation in general wards for acute respiratory failure
NAVIGATE: Early noninvasive ventilation in general wards for acute respiratory failure Monti et al. for the NAVIGATE Study Group, BJA Feb 2025. doi:10.1016/j.bja.2024.11.023 Clinical Question In adult patients with mild acute respiratory failure (ARF), does a regime of 2-hour cycles of noninvasive ventilation (NIV), delivered on general wards every 8 hours, reduce the progression to severe acute respiratory failure (defined […]
Continue reading »BALANCE – 7 vs 14 days of antibiotics
Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections BALANCE Investigators. NEJM 2024; DOI: 10.1056/NEJMoa2404991 Clinical Question In hospitalised patients with bloodstream infections (BSI), is antibiotic treatment for 7 days, compared to treatment for 14 days, non-inferior with respect to mortality at 90 days? Background BSI are common and a leading cause of mortality and morbidity, accounting […]
Continue reading »ADAPT-Sepsis: PCT or CRP Guided Antibiotic Duration
ADAPT-Sepsis: PCT or CRP-guided Antibiotic Duration for Patients with suspected Sepsis Dark et al. JAMA Dec 9 2024. doi:10.1001/jama.2024.26458 Clinical Question For critically ill adults with suspected sepsis, does a procalcitonin (PCT) guided or C-reactive protein (CRP) guided antibiotic discontinuation prompt, compared with usual care, reduce the total duration of antibiotics without increasing all-cause 28-day mortality? Background Shorter antibiotic durations […]
Continue reading »Continued enteral nutrition until extubation compared with fasting before extubation
Continued enteral nutrition until extubation compared with fasting before extubation in patients in the intensive care unit: an open-label, cluster-randomised, parallel-group, non-inferiority trial Landais et al. The Lancet Respiratory Medicine 2023. 11:319-28. doi://10.1016/ S2213-2600(22)00413-1 Clinical Question In patients ventilated for more than 48h in the Intensive Care Unit, is continued enteral nutrition compared with fasting prior to extubation, non-inferior with […]
Continue reading »Critical Care Evidence Updates – December 2024
What’s new in the Critical Care literature – monthly updates
Continue reading »Emergency Evidence Updates – December 2024
What’s new in the Critical Care literature – monthly updates
Continue reading »ASTER – Acetaminophen in Sepsis
Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis Ware. JAMA 2024. doi:10.1001/jama.2024.8772 Clinical Question In critically ill adult patients with sepsis does the administration of acetaminophen compared to placebo increase the number of days alive and free of organ support to day 28? Background Acetaminophen is a potent and specific haemoprotein reductant that can […]
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