Critical Care Evidence Updates – August 2022

Randomised Controlled Trials

Acetazolamide in Acute Decompensated Heart Failure with Volume Overload  NEJM

An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis (DEFINE): A Phase Ib/IIa Randomised Controlled Trial  American Journal of Respiratory and Critical Care Medicine

Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest  NEJM

Continuous intra-arterial versus intermittent oscillometric arterial pressure monitoring and hypotension during induction of anaesthesia: the AWAKE randomised trial  British Journal of Anaesthesia

Driving pressure-guided ventilation and postoperative pulmonary complications in thoracic surgery: a multicentre randomised clinical trial  British Journal of Anaesthesia

Effect of high versus low dose of dexamethasone on clinical worsening in patients hospitalised with moderate or severe COVID-19 pneumonia: an open-label, randomised clinical trial  European Respiratory Journal

Effect of Intravenous Tirofiban vs Placebo Before Endovascular Thrombectomy on Functional Outcomes in Large Vessel Occlusion Stroke – The RESCUE BT Randomized Clinical Trial  JAMA

Effect of Remote Ischemic Conditioning vs Usual Care on Neurologic Function in Patients With Acute Moderate Ischemic Stroke – The RICAMIS Randomized Clinical Trial  JAMA

Effects of mean arterial pressure target on mottling and arterial lactate normalization in patients with septic shock: a post hoc analysis of the SEPSISPAM randomized trial  Annals of Intensive Care

Oxygen Targets in Comatose Survivors of Cardiac Arrest  NEJM

Reduction in transfer of micro-organisms between patients and staff using short-sleeved gowns and hand/arm hygiene in intensive care during the COVID-19 pandemic: A simulation-based randomised trial  Journal of the Intensive Care Society

The Use of IV Vasoactive Intestinal Peptide (Aviptadil) in Patients With Critical COVID-19 Respiratory Failure: Results of a 60-Day Randomized Controlled Trial  Critical Care Medicine

Timing of Exposure to ICU Diaries and Its Impact on Mental Health, Memories, and Quality of Life: A Double-Blind Randomized Control Trial  Critical Care Explorations


SecurAcath for securing percutaneous catheters MTG34

Superficial venous arterialisation for chronic limb threatening ischaemia IPG736

Other Guidance/Reports

Clinical sepsis phenotypes in critically ill COVID-19 patients  Critical Care

ESC Congress 2022 Guidelines  European Heart Journal

Interviews with primary care physicians identify unmet transition needs after ICU  Critical Care

Management of Decompensated Cirrhosis in the Surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document  Trauma Surgery & Acute Care Open

New drugs for acute kidney injury  Intensive Care Medicine

Preventing pressure injuries among patients in the intensive care unit: insights gained

Intensive Care Medicine

Preventing unrecognised oesophageal intubation: a consensus guideline from the Project for Universal Management of Airways and international airway societies*  Anaesthesia

Update June 2022: management of hospitalised adults with coronavirus disease 2019 (COVID-19): a European Respiratory Society living guideline  European Respiratory Journal

Update on vitamin C administration in critical illness  Current Opinion in Critical Care


Interventions for preventing and reducing the use of physical restraints of older people in general hospital settings

Primary Research

A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial  Critical Care

A Care Step Pathway for the Diagnosis and Treatment of COVID-19–Associated Invasive Fungal Infections in the Intensive Care Unit  Critical Care Nurse

A Multiple Baseline Trial of an Electronic ICU Discharge Summary Tool for Improving Quality of Care  Critical Care Medicine

A thematic analysis of staff perspectives on the impact of a mental health nurse (RMN) in a critical care unit  Journal of the Intensive Care Society

A stratification strategy to predict secondary infection in critical illness-induced immune dysfunction: the REALIST score  Annals of Intensive Care

Acute bilateral parotid swelling upon laryngeal mask airway insertion: A case report  Anaesthesia and Intensive Care

Association between histological diaphragm atrophy and ultrasound diaphragm expiratory thickness in ventilated patients  Journal of Intensive Care

Bebtelovimab-Induced Bradycardia Leading to Cardiac Arrest  Critical Care Explorations

Care practices for patients requiring mechanical ventilation more than seven days in Swedish intensive care units: A national survey  Intensive and Critical Care Nursing

Clinical validation of a multiplex droplet digital PCR for diagnosing suspected bloodstream infections in ICU practice: a promising diagnostic tool  Critical Care

Co-infection and ICU-acquired infection in COVID-19 ICU patients: a secondary analysis of the UNITE-COVID data set  Critical Care

Comparison of different clinical risk scores to predict long-term survival and neurological outcome in adults after cardiac arrest: results from a prospective cohort study  Annals of Intensive Care

Core outcome measures for clinical effectiveness trials of nutritional and metabolic interventions in critical illness: an international modified Delphi consensus study evaluation (CONCISE)  Critical Care

Development and Implementation of an Ultrasound-Guided Peripheral Intravenous Catheter Education Program for Critical Care Nurses  Dimensions of Critical Care Nursing

Duration of resuscitation and long-term outcome after in-hospital cardiac arrest: A nationwide observational study  Resuscitation

Early hyperoxia and 28-day mortality in patients on venoarterial ECMO support for refractory cardiogenic shock: a bicenter retrospective propensity score-weighted analysis  Critical Care

Early prediction of hospital outcomes in patients tracheostomized for complex mechanical ventilation weaning  Annals of Intensive Care

Early steroids and ventilator-associated pneumonia in COVID-19-related ARDS  Critical Care

Ecological effects of selective oral decontamination on multidrug-resistance bacteria acquired in the intensive care unit: a case–control study over 5 years  Intensive Care Medicine

Effects of Ketamine Infusion on Breathing and Encephalography in Spontaneously Breathing ICU Patients  Journal of Intensive Care Medicine

Elimination of Herpes Simplex Virus-2 and Epstein-Barr Virus With Seraph 100 Microbind Affinity Blood Filter and Therapeutic Plasma Exchange: An Explorative Study in a Patient With Acute Liver Failure  Critical Care Explorations

Exploration of a rapid response team model of care: A descriptive dual methods study  Intensive and Critical Care Nursing

Family support in intensive care units during COVID-19 visit ban: A multinational Delphi Study during first COVID-19 wave  Intensive and Critical Care Nursing

How do intensive care clinicians ensure culturally sensitive care for family members at the end of life? A retrospective descriptive study  Intensive and Critical Care Nursing

Impact of Family Presence on Delirium in Critically Ill Patients: A Retrospective Cohort Study  Critical Care Medicine

Impact of Macintosh blade size on endotracheal intubation success in intensive care units: a retrospective multicenter observational MacSize-ICU study  Intensive Care Medicine

In-Hospital Depressed Level of Consciousness and Long-Term Functional Outcomes in ICU Survivors  Critical Care Medicine

Kinetics of capillary refill time after fluid challenge  Annals of Intensive Care

Low-dose intravenous plus inhaled versus intravenous polymyxin B for the treatment of extensive drug-resistant Gram-negative ventilator-associated pneumonia in the critical illnesses: a multi-center matched case–control study  Annals of Intensive Care

Management and outcomes of pregnant women admitted to intensive care unit for severe pneumonia related to SARS-CoV-2 infection: the multicenter and international COVIDPREG study   Intensive Care Medicine

Mental health-related quality of life is related to delirium in intensive care patients  Intensive Care Medicine

Mental well-being of ICU nurses after the second surge of the COVID-19 pandemic: A cross-sectional and longitudinal study  Intensive and Critical Care Nursing

Modulation of the Association Between Age and Death by Risk Factor Burden in Critically Ill Patients With COVID-19  Critical Care Explorations

Multisystem Inflammatory Syndrome in Adults (MIS-A) After COVID-19 Infection and Recent Vaccination with Recombinant Adenoviral Vector Encoding the Spike Protein Antigen of SARS-CoV-2 (ChAdOx1 nCoV-19, Vaxzevria)  Journal of Intensive Care Medicine

Muscular myostatin gene expression and plasma concentrations are decreased in critically ill patients  Critical Care

One Year Post-Discharge Outcomes After Implementation of an ICU Early Mobility Protocol  Dimensions of Critical Care Nursing

Optimal bispectral index level of sedation and cerebral oximetry in traumatic brain injury: a non-invasive individualized approach in critical care?  Intensive Care Medicine Experimental

Optimization of central venous pressure during the perioperative period is associated with improved prognosis of high-risk operation patients  Journal of Intensive Medicine

Outcomes and Prognostic Factors of Pulmonary Hypertension Patients Undergoing Emergent Endotracheal Intubation  Journal of Intensive Care Medicine

Physiologic responses to exercise in survivors of critical illness: an exploratory pilot study  Intensive Care Medicine Experimental

Plasma volume expansion reveals hidden metabolic acidosis in patients with diabetic ketoacidosis  Intensive Care Medicine Experimental

Poor long-term recovery after critical COVID-19 during 12 months longitudinal follow-up  Intensive and Critical Care Nursing

Practical Strategies Related to the Application of Balloon Tamponade Therapy in Acute Variceal Bleeding  Critical Care Explorations

Preoperative cardiopulmonary exercise testing improves risk assessment of morbidity and length of stay following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy  Anaesthesia and Intensive Care

Psychological Attachment Orientation and Long-Term Posttraumatic Stress Symptoms Among Family Members of ICU Patients  Critical Care Explorations

Psychological distress and morbidity of family members experiencing virtual visiting in intensive care during COVID-19: an observational cohort study  Intensive Care Medicine

Strategies for lung- and diaphragm-protective ventilation in acute hypoxemic respiratory failure: a physiological trial  Critical Care

Stress Hyperphenylalaninemia Is Associated With Mortality in Cardiac ICU: Clinical Factors, Genetic Variants, and Pteridines  Critical Care Medicine

The Chronological Demographics of Ventricular-Arterial Decoupling in Patients with Sepsis and Septic Shock: A Prospective Observational Study  Journal of Intensive Care Medicine

The Efficacy of Albumin Dialysis in the Treatment of Severe Cholestatic Drug-Induced Liver Injury  Critical Care Explorations

The lived experience by patients and family members of extracorporeal membrane oxygenation: A qualitative study  Intensive and Critical Care Nursing

The use of ICU resources in CAR-T cell recipients: a hospital-wide study  Annals of Intensive Care

Time-varying intensity of oxygen exposure is associated with mortality in critically ill patients with mechanical ventilation  Critical Care

Trauma-induced coagulopathy  Intensive Care Medicine

Using real-time visualization system for data-driven decision support to achieve lung protective strategy: a retrospective observational study  Critical Care

Visual and auditory stimulation for patients in the intensive care unit: A mixed-method study  Intensive and Critical Care Nursing


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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