Critical Care Evidence Updates – August 2024

Randomised Controlled Trials

Automatic Mechanical Ventilation vs Manual Bag Ventilation During CPR – A Pilot Randomized Controlled Trial  Chest

Beta-Blocker Interruption or Continuation after Myocardial Infarction  NEJM

Collateral-based selection for endovascular treatment of acute ischaemic stroke in the late window (MR CLEAN-LATE): 2-year follow-up of a phase 3, multicentre, open-label, randomised controlled trial in the Netherlands  The Lancet Neurology

Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery  The Stop-or-Not Randomized Clinical Trial  JAMA

Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in Belgium and the Netherlands  The Lancet

Efficacy and Safety of Early Treatment with Glibenclamide in Patients with Aneurysmal Subarachnoid Hemorrhage: A Randomized Controlled Trial  Neurocritical Care

First-attempt awake tracheal intubation success rate using a hyperangulated unchannelled videolaryngoscope vs. a channelled videolaryngoscope in patients with anticipated difficult airway: a randomised controlled trial  Anaesthesia

Long-term effects of flexible visitation in the intensive care unit on family members’ mental health: 12-month results from a randomized clinical trial  Intensive Care Medicine

Lower-Dosage Acute Peritoneal Dialysis versus Acute Intermittent Hemodialysis in Acute Kidney Injury A Randomized Controlled Trial  CJASN

Nasal high flow or noninvasive ventilation? navigating hypercapnic COPD exacerbation treatment: A randomized noninferiority clinical trial Respiratory Medicine

Potassium Supplementation and Prevention of Atrial Fibrillation After Cardiac Surgery – The TIGHT K Randomized Clinical Trial  JAMA

Prolonged vs shorter awake prone positioning for COVID-19 patients with acute respiratory failure: a multicenter, randomised controlled trial  Intensive Care Medicine

Suvorexant for Reduction of Delirium in Older Adults After Hospitalization – A Randomized Clinical Trial  JAMA Network Open

 

NICE

Adrenal insufficiency: identification and management NG243

 

Other Guidance/Reports

2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): Developed by the task force for the management of atrial fibrillation of the European Society of Cardiology (ESC), with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Endorsed by the European Stroke Organisation (ESO)  European Heart Journal

2024 ESC Guidelines for the management of elevated blood pressure and hypertension: Developed by the task force on the management of elevated blood pressure and hypertension of the European Society of Cardiology (ESC) and endorsed by the European Society of Endocrinology (ESE) and the European Stroke Organisation (ESO)  European Heart Journal

2024 European Society of Hypertension clinical practice guidelines for the management of arterial hypertension  European Journal of Internal Medicine

AARC Clinical Practice Guideline: Patient-Ventilator Assessment  Respiratory Care

Anesthesiologists ultrasound-guided regional anesthesia core curriculum: a Delphi consensus from Italian regional anesthesia experts  Journal of Anesthesia, Analgesia and Critical Care

Definition and management of right ventricular injury in adult patients receiving extracorporeal membrane oxygenation for respiratory support using the Delphi method: a PRORVnet study. Expert position statements  Intensive Care Medicine

ESPEN practical guideline on clinical nutrition in hospitalized patients with acute or chronic kidney disease  Clinical Nutrition

Expert perspectives on ECCO₂R for acute hypoxemic respiratory failure: consensus of a 2022 European roundtable meeting  Annals of Intensive Care

Guideline on positioning and early mobilisation in the critically ill by an expert panel  Intensive Care Medicine

Imaging in acute percutaneous mechanical circulatory support in adults. A clinical consensus statement of the Association for Acute CardioVascular Care (ACVC) of the ESC, the European Association of Cardiovascular Imaging (EACVI) of the ESC and the European branch of the Extracorporeal Life Support Organization (EuroELSO)  Cardiovascular Imaging

International consensus definitions for infection-triggered encephalopathy syndromes  Developmental Medicine & Child Neurology

International Initiatives of the American Heart Association: Original Concepts, Present Programs, and Future Focus: A Science Advisory From the American Heart Association  Circulation

Intraoperative somatosensory evoked potential (SEP) monitoring: an updated position statement by the American Society of Neurophysiological Monitoring  Journal of Clinical Monitoring and Computing

Ketamine analgo-sedation for mechanically ventilated critically ill adults: A rapid practice guideline from the Saudi Critical Care Society and the Scandinavian Society of Anesthesiology and Intensive Care Medicine  Acta Anaesthesiologica Scandinavica

Key summary of German national guideline for adult patients with nosocomial pneumonia- Update 2024 Funding number at the Federal Joint Committee (G-BA): 01VSF22007  Infection

Obesity and cardiovascular disease: an ESC clinical consensus statement  European Heart Journal

Recommendations for clinical trial design in acute kidney injury from the 31st acute disease quality initiative consensus conference. A consensus statement  Intensive Care Medicine

The use of angiotensin II for the management of distributive shock: expert consensus statements  Journal of Anesthesia, Analgesia and Critical Care

 

Cochrane

Accuracy of routine laboratory tests to predict mortality and deterioration to severe or critical COVID‐19 in people with SARS‐CoV‐2

Non‐surgical interventions for preventing contralateral tissue loss and amputation in dysvascular patients with a primary major lower limb amputation

 

Primary Research

A modified screening protocol for ARDS in patients with respiratory support based on SpO₂ and FiO₂: A single-center prospective, observational study  Journal of Intensive Medicine

A pilot feasibility study comparing large language models in extracting key information from ICU patient text records from an Irish population  Intensive Care Medicine Experimental

A retrospective registry-based study into the proportion of patients admitted to intensive care who have anaphylaxis as a principal diagnosis and their outcomes in Australia and New Zealand  Critical Care and Resuscitation

Accelerometer-derived movement features as predictive biomarkers for muscle atrophy in neurocritical care: a prospective cohort study  Critical Care

Alteration in early resting‑state functional MRI activity in comatose survivors of cardiac arrest: a prospective cohort study  Critical Care

Association of norepinephrine with pressure ulcer development in critically ill patients with COVID-19-related acute respiratory distress syndrome: A dose–response analysis  Intensive and Critical Care

Changes in nitric oxide inhibitors and mortality in critically ill patients: a cohort study  Annals of Intensive Care

Clinical phenotyping uncovers heterogeneous associations between corticosteroid treatment and survival in critically ill COVID-19 patients  Intensive Care Medicine

Combination of Hydrogen Inhalation and Hypothermic Temperature Control After Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care II Trial  Critical Care Medicine

Comparison of Tenecteplase Versus Alteplase for the Treatment of Pulmonary Embolism and Cardiac Arrest with Suspected Pulmonary Embolism  Journal of Intensive Care Medicine

Conservative or liberal oxygen targets in patients on venoarterial extracorporeal membrane oxygenation  Intensive Care Medicine

Conservative Treatment of Mesenteric and Hepatic Portal Venous Gas Caused by Gut-Derived Infection After Ileostomy: A Case Report  Critical Care Nurse

Contribution of intrapulmonary shunt to the pathogenesis of profound hypoxaemia in viral infection: a mechanistic discussion with an illustrative case  Journal of the Intensive Care Society

Correlation and concordance of carotid Doppler ultrasound and echocardiography with invasive cardiac output measurement in critically ill patients  Intensive Care Medicine Experimental

Derivation and external validation of predictive models for invasive mechanical ventilation in intensive care unit patients with COVID-19  Annals of Intensive Care

Dexmedetomidine Improves Microcirculatory Alterations in Patients With Initial Resuscitated Septic Shock  Journal of Intensive Care Medicine

Droxidopa for Vasopressor Weaning in Critically Ill Patients with Persistent Hypotension: A Multicenter, Retrospective, Single-Arm Observational Study  Journal of Intensive Care Medicine

Early reapplication of prone position during venovenous ECMO for acute respiratory distress syndrome: a prospective observational study and propensity-matched analysis  Annals of Intensive Care

Emergency Department Triage, Transfer Times, and Hospital Mortality of Patients Admitted to the ICU: A Retrospective Replication and Continuation Study  Critical Care Medicine

Evaluating the Appropriateness, Consistency, and Readability of ChatGPT in Critical Care Recommendations  Journal of Intensive Care Medicine

Eye tracking during a simulated start of shift safety check: An observational analysis of gaze behavior of critical care nurses  Journal of the Intensive Care Society

Factors associated with cancer treatment resumption after ICU stay in patients with solid tumors  Annals of Intensive Care

Factors predicting mortality in the cardiac ICU during the early phase of targeted temperature management in the treatment of post-cardiac arrest syndrome – The RAPID score  Resuscitation Plus

Fluid boluses and infusions in the early phase of resuscitation from septic shock and sepsis-induced hypotension: a retrospective report and outcome analysis from a tertiary hospital  Annals of Intensive Care

High expression of L-GILZ transcript variant 1 (GILZ TV 1) is associated with increased 30-day sepsis mortality, and a high expression ratio possibly contraindicates hydrocortisone administration  Critical Care

High frequency oscillations may improve somatosensory evoked potential detection of good outcomes in disorders of consciousness secondary to acute neurologic injury  Resuscitation

ICU-Electroencephalogram Unit Improves Outcome in Status Epilepticus Patients: A Retrospective Before-After Study  Critical Care Medicine

Immunomodulators in patients receiving extracorporeal membrane oxygenation for COVID-19: a propensity-score adjusted analysis of the ELSO registry  Annals of Intensive Care

Impact of Hemoglobin Levels on Composite Cardiac Arrest or Stroke Outcome in Patients With Respiratory Failure Due to COVID-19  Critical Care Explorations

Impact of inhaled sedation on delirium incidence and neurological outcome after cardiac arrest – A propensity-matched control study (Isocare)  Resuscitation

Incorporating Patient Values in Large Language Model Recommendations for Surrogate and Proxy Decisions  Critical Care Explorations

“It’s all about setting the stage.” The nurse facilitator trial: perceived outcomes and implementation issues. A qualitative study among ICU clinicians and nurse facilitators  Intensive Care Medicine

Long-term survival comparison of patients admitted to the intensive care unit following in-hospital cardiac arrest in perioperative and ward settings. A multicentre retrospective cohort study  Intensive Care Medicine

Machine Learning Tools for Acute Respiratory Distress Syndrome Detection and Prediction  Critical Care Medicine

Moderate IV Fluid Resuscitation Is Associated With Decreased Sepsis Mortality  Critical Care Medicine

Modes of administration of nitric oxide devices and ventilators flow-by impact the delivery of pre-determined concentrations  Annals of Intensive Care

Neurologic complications in patients receiving aortic versus subclavian versus femoral arterial cannulation for post-cardiotomy extracorporeal life support: results of the PELS observational multicenter study  Critical Care

Neuroprognostication, withdrawal of care and long-term outcomes after cardiopulmonary resuscitation  Current Opinion in Critical Care

Nociception level index variations in ICU: curarized vs non-curarized patients — a pilot study  Journal of Anesthesia, Analgesia and Critical Care

Nurse Practitioner and Physician Assistant-led Cardiovascular Surgery Postoperative Intensive Care Unit Staffing Model  Journal of Intensive Care Medicine

Pericardiocentesis, Chest Tube Insertion, and Needle Thoracostomy During Resuscitation of Nontraumatic Adult In-Hospital Cardiac Arrest: A Retrospective Cohort Study  Critical Care Explorations

Phenotyping COVID-19 respiratory failure in spontaneously breathing patients with AI on lung CT-scan  Critical Care

Point-of-care creatinine vs. central laboratory creatinine in the critically ill  Critical Care and Resuscitation

Post-discharge functional outcomes in older patients with sepsis  Critical Care

Redefining urine output thresholds for acute kidney injury criteria in critically Ill patients: a derivation and validation study  Critical Care

Reducing Central Line–Associated Bloodstream Infections With a Multipronged Nurse-Driven Approach  Critical Care Nurse

Research report: Management of dysphagia using pharyngeal electrical stimulation in the general intensive care population – A service development  Journal of the Intensive Care Society

Retrospective ANalysis of multi-drug resistant Gram-nEgative bacteRia on veno-venous extracorporeal membrane oxygenation. The multicenter RANGER STUDY  Critical Care

Standard versus individualised positive end-expiratory pressure (PEEP) compared by electrical impedance tomography in neurocritical care: a pilot prospective single centre study  Intensive Care Medicine Experimental

Stroke Volume and Stroke Volume Variation, but not Cardiac Index Is Associated With Survival of Majorly Burned Patients in Early Burn Shock  Journal of Intensive Care Medicine

The Impact of Delayed Transition From Noninvasive to Invasive Mechanical Ventilation on Hospital Mortality in Immunocompromised Patients With Sepsis  Critical Care Medicine

The use of echocardiography in the management of shock in critical care: a prospective, multi-centre, observational study  Intensive Care Medicine

Urine Output and Development of Acute Kidney Injury in Sepsis: A Multicenter Observational Study  Journal of Intensive Care Medicine

Validating quantitative pupillometry thresholds for neuroprognostication after out-of-hospital cardiac arrest. A predefined substudy of the Blood Pressure and Oxygenations Targets After Cardiac Arrest (BOX)-trial  Intensive Care Medicine

Venous return physiology applied to post-cardiac arrest haemodynamic management: a post hoc analysis of the NEUROPROTECT trial  Intensive Care Medicine Experimental

VV-ECMO in critical COVID-19 obese patients: a cohort study  Journal of Anesthesia, Analgesia and Critical Care

 

Metadata

Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash