Critical Care Evidence Updates – December 2021


COVID-19 rapid guideline: managing COVID-19 NG191

FreeO2 automatic oxygen titration for chronic obstructive pulmonary disease and respiratory distress syndrome – medtech innovation briefing (MIB281)

Other Guidance/Reports

A guide to enteral nutrition in intensive care units: 10 expert tips for the daily practice Critical Care

Ask. Listen. Act. (2nd edition) (PDF) RCN

Assessment of the further emergence of the SARS-CoV-2 Omicron VOC in the context of the ongoing Delta VOC transmission in the EU/EEA, 18th update (PDF) European Centre for Disease Prevention and Control

COVID-19: Preventing nosocomial infection in older people British Geriatrics Society

Deprivation of liberty safeguards BMA

Physiotherapy management for COVID-19 in the acute hospital setting and beyond: an update to clinical practice recommendations Journal of Physiotherapy


Autogenic drainage for airway clearance in cystic fibrosis

Transfusion thresholds for guiding red blood cell transfusion

Systematic Reviews from Other Sources

Bag-Mask Ventilation Versus Apneic Oxygenation During Tracheal Intubation in Critically Ill Adults: A Secondary Analysis of 2 Randomized Trials Journal of Intensive Care Medicine

Hydrocortisone, ascorbic acid, and thiamine (HAT) for sepsis and septic shock: a meta-analysis with sequential trial analysis Journal of Intensive Care

Inappropriate treatment at the end of life: a systematic review of qualitative evidence (PDF) Evidence for Policy and Practice Information and Co-ordinating Centre

Medical futility regarding cardiopulmonary resuscitation in in-hospital cardiac arrests of adult patients: A systematic review and Meta-analysis Resuscitation

Quality appraisal of guidelines on physical restraints in intensive care units: A systematic review Intensive and Critical Care Nursing

Utilization and outcomes of extracorporeal CO2 removal (ECCO2R): Systematic review and meta-analysis of arterio-venous and veno-venous ECCO2R approaches Artificial Organs

Videolaryngoscopy vs. direct Macintosh laryngoscopy in tracheal intubation in adults: a ranking systematic review and network meta-analysis Anaesthesia

Primary Research

A pilot study of trained ICU doulas providing early psychological support to critically ill patients Critical Care

A qualitative study of nurses’ perception on patients’ thirst in intensive care units Intensive and Critical Care Nursing

Albumin and fibrinogen kinetics in sepsis: a prospective observational study Critical Care

An Evidence-Based Protocol for Manual Prone Positioning of Patients With ARDS Critical Care Nurse

Analysis of Intent and Reason for Oncologic Therapy Administration in Cancer Patients Admitted to the Intensive Care Unit Journal of Intensive Care Medicine

Assessment of Safety of Remdesivir in Covid −19 Patients with Estimated Glomerular Filtration Rate (eGFR) < 30 ml/min per 1.73 m^2 Journal of Intensive Care Medicine

Association between mortality and age among mechanically ventilated COVID-19 patients: a Japanese nationwide COVID-19 database study Annals of Intensive Care

Association of Surge Conditions with Mortality Among Critically Ill Patients with COVID-19 Journal of Intensive Care Medicine

Automated left atrial strain analysis for predicting atrial fibrillation in severe COVID-19 pneumonia: a prospective study Annals of Intensive Care

Awake prone position reduces work of breathing in patients with COVID-19 ARDS supported by CPAP Annals of Intensive Care

Bag valve resuscitator versus Mapleson C circuit during manual ventilation: A bench top study Intensive and Critical Care Nursing

Benefits and risks of noninvasive oxygenation strategy in COVID-19: a multicenter, prospective cohort study (COVID-ICU) in 137 hospitals Critical Care

Bleeding and thrombotic events in adults supported with venovenous extracorporeal membrane oxygenation: an ELSO registry analysis Intensive Care Medicine

Changes in carbon dioxide production and oxygen uptake evaluated using indirect calorimetry in mechanically ventilated patients with sepsis Critical Care

Characteristics and prognosis of bloodstream infection in patients with COVID-19 admitted in the ICU: an ancillary study of the COVID-ICU study Annals of Intensive Care

Clinical characteristics and risk factors associated with mortality in patients with severe community-acquired pneumonia and type 2 diabetes mellitus Critical Care

Development of a new score for early mortality prediction in trauma ICU patients: RETRASCORE Critical Care

Diagnosing capillary leak in critically ill patients: development of an innovative scoring instrument for non-invasive detection Annals of Intensive Care

Diagnostic Sensitivity of Plasma Endothelin-1 for Cerebral Vasospasm After Subarachnoid Hemorrhage, a Multicentre Double-Blind Study Journal of Intensive Care Medicine

Do alterations in pulmonary vascular tone result in changes in central blood volumes? An experimental study Intensive Care Medicine Experimental

Early Use of Sarilumab in Patients Hospitalised with COVID-19 Pneumonia and Features of Systemic Inflammation. Antimicrobial Agents and Chemotherapy

Effect of a backboard on chest compression quality during in-hospital adult cardiopulmonary resuscitation: A randomised, single-blind, controlled trial using a manikin model Intensive and Critical Care Nursing

Effect of a Multiorgan Focused Clinical Ultrasonography on Length of Stay in Patients Admitted With a Cardiopulmonary Diagnosis A Randomized Clinical Trial JAMA Network Open

Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19 A Randomized Clinical Trial JAMA

Effect of Regional vs General Anesthesia on Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery The RAGA Randomized Trial JAMA

Effect of Use of a Bougie vs Endotracheal Tube With Stylet on Successful Intubation on the First Attempt Among Critically Ill Patients Undergoing Tracheal Intubation – A Randomized Clinical Trial JAMA

Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients – A Randomized Clinical Trial JAMA Internal Medicine

ESCAPE: An Open-Label Trial of Personalized Immunotherapy in Critically ill COVID-19 Patients Journal of Innate Immunity

Etomidate versus ketamine for emergency endotracheal intubation: a randomized clinical trial Intensive Care Medicine

Exploring population pharmacokinetic models in patients treated with vancomycin during continuous venovenous haemodiafiltration (CVVHDF) Critical Care

Favorable Outcomes After Implementing a Nurse-Driven Sedation Protocol Critical Care Nurse

Feasibility of conservative fluid administration and deresuscitation compared with usual care in critical illness: the Role of Active Deresuscitation After Resuscitation‑2 (RADAR‑2) randomised clinical trial Intensive Care medicine

Flow Index accurately identifies breaths with low or high inspiratory effort during pressure support ventilation Critical Care

Gas conditioning during helmet noninvasive ventilation: effect on comfort, gas exchange, inspiratory effort, transpulmonary pressure and patient–ventilator interaction Annals of Intensive Care

Glutamine relieves the hypermetabolic response and reduces organ damage in severe burn patients: A multicenter, randomized controlled clinical trial Burns

High- Versus Low-Dose Dexamethasone for the Treatment of COVID-19-Related Acute Respiratory Distress Syndrome: A Multicenter, Randomized Open-Label Clinical Trial Journal of Intensive Care Medicine

HSV-1 reactivation is associated with an increased risk of mortality and pneumonia in critically ill COVID-19 patients Critical Care

Impact of rewarming rate on interleukin-6 levels in patients with shockable cardiac arrest receiving targeted temperature management at 33 °C: the ISOCRATE pilot randomized controlled trial Critical Care

Implementation of nonpharmacologic physical restraint minimization interventions in the adult intensive care unit: A scoping review Intensive and Critical Care Nursing

Incidence, characteristics and risk factors of medical device-related pressure injuries: An observational cohort study Intensive and Critical Care Nursing

Intensive care unit versus high-dependency care unit for patients with acute heart failure: a nationwide propensity score-matched cohort study Journal of Intensive Care

Intravenous albumin for the prevention of hemodynamic instability during sustained low-efficiency dialysis: a randomized controlled feasibility trial (The SAFER-SLED Study) Annals of Intensive Care

Intravenous iron to treat anaemia following critical care: a multicentre feasibility randomised trial British Journal of Anaesthesia

Lenzilumab in hospitalised patients with COVID-19 pneumonia (LIVE-AIR): a phase 3, randomised, placebo-controlled trial The Lancet Respiratory Medicine

Lung histopathologic clusters in severe COVID-19: a link between clinical picture and tissue damage Critical Care

Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges Intensive Care Medicine Experimental

Molecular mechanisms of postintensive care syndrome Intensive Care Medicine Experimental

Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, phase 2, proof-of-concept trial The Lancet Respiratory Medicine

Novel protocol combining physical and nutrition therapies, Intensive Goal-directed REhabilitation with Electrical muscle stimulation and Nutrition (IGREEN) care bundle Critical Care

Nurse perceptions of a nurse family liaison implemented during the COVID-19 pandemic: A qualitative thematic analysis Intensive and Critical Care Nursing

Nurse-performed ultrasound assessment of gastric residual volume and enteral nasogastric tube placement in the general intensive care unit Intensive and Critical Care Nursing

Nursing points of interest when nebulizing antibiotics in ventilated patients Intensive and Critical Care Nursing

Outcomes of a Delirium Prevention Program in Older Persons After Elective Surgery – A Stepped-Wedge Cluster Randomized Clinical Trial JAMA Surgery

Patient discharge from intensive care: an updated scoping review to identify tools and practices to inform high-quality care Critical Care

Positive end-expiratory pressure in COVID-19 acute respiratory distress syndrome: the heterogeneous effects Critical Care

Practical strategies for airway clearance in patients with severe COVID-19 Intensive and Critical Care Nursing

Predicting 90-day survival of patients with COVID-19: Survival of Severely Ill COVID (SOSIC) scores Annals of Intensive Care

Predictors for extubation failure in COVID-19 patients using a machine learning approach Critical Care

Propofol as a Drug of Diversion: Changing Disposal Practices to Reduce Risk Critical Care Nurse

Proportional assist ventilation relieves clinically significant dyspnea in critically ill ventilated patients Annals of Intensive Care

Prospective international validation of the predisposition, infection, response and organ dysfunction (PIRO) clinical staging system among intensive care and general ward patients Annals of Intensive Care

Real-world corticosteroid use in severe pneumonia: a propensity-score-matched study Critical Care

Recent Advances in Bedside Device-Based Early Detection of Sepsis Journal of Intensive Care Medicine

Single-dose of adrecizumab versus placebo in acute cardiogenic shock (ACCOST-HH): an investigator-initiated, randomised, double-blinded, placebo-controlled, multicentre trial The Lancet Respiratory Medicine

Stimulating severe COVID-19: the potential role of GM-CSF antagonism The Lancet Respiratory Medicine

Surface EMG-based quantification of inspiratory effort: a quantitative comparison with Pes Critical Care

The accuracy of various neuro-prognostication algorithms and the added value of neurofilament light chain dosage for patients resuscitated from shockable cardiac arrest: An ancillary analysis of the ISOCRATE study Resuscitation

The effect of the volemic and cardiac status on brain oxygenation in patients with subarachnoid hemorrhage: a bi-center cohort study Annals of Intensive Care

The patient and their family’s perspectives on agitation and its management in adult critical care: A qualitative study Intensive and Critical Care Nursing

Three bedside techniques to quantify dynamic pulmonary hyperinflation in mechanically ventilated patients with chronic obstructive pulmonary disease Annals of Intensive Care


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date: 4th January 2022
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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