Does treatment with vitamin C, hydrocortisone, and thiamine lead to a more rapid resolution of septic shock compared with hydrocortisone alone?Continue reading »
Do one or more doses of levocarnitine reduce organ failure in septic shock at 48 hours, compared with placebo?Continue reading »
In patients undergoing cardiac surgery, who have a moderate-to-high risk of death, does a restrictive transfusion strategy compared with a liberal strategy impact on a composite outcome of death, myocardial infarction, stroke and acute kidney injury requiring dialysis at 6 months after surgery?Continue reading »
In adult patients with non-traumatic out-of-hospital cardiac arrest, does a supraglottic airway device compared with tracheal intubation as the initial advanced airway management strategy, improve functional neurological outcome?Continue reading »
In critically ill patients with severe metabolic acidaemia (pH ≤7⋅20), does the infusion of sodium bicarbonate, compared with no infusion, to reach and maintain a targeted pH of 7⋅30 decrease the primary composite outcome of mortality by day 28 or the presence of at least one organ failure at day 7?Continue reading »
In adult patients undergoing major elective abdominal surgery, does a restrictive fluid regimen compared with a liberal fluid regimen reduce complications and improved disability-free survival?Continue reading »
In patients with septic shock, do corticosteroids compared to placebo reduce mortality?
This is an editorial blog post in anticipation of the ADRENAL trial results to be presented at #CCR18.
Intensive versus standard physical rehabilitation therapy in the critically ill (EPICC): a multicentre, parallel-group, randomised controlled trial Wright. 2017. Thorax 2017: 0:1–9. doi:10.1136/thoraxjnl-2016-209858 Clinical Question Does an increased intensity of ICU based physical rehabilitation therapy improve improve long-term physical quality of life compared with a standard intensity of physical rehabilitation? Background Physical and psychological recovery after a period of critical […]Continue reading »
P-values – interpreting the evidence seriesContinue reading »
Among relatives who died in the Intensive Care Unit (ICU), does a condolence letter from a clinician, compared to no condolence letter, effect grief symptoms?Continue reading »