Critical Care Evidence Updates – December 2022

Randomised Controlled Trials

Adjunctive granisetron therapy in patients with sepsis or septic shock (GRANTISS): A single-center, single-blinded, randomized, controlled clinical trial  – Frontiers in Pharmacology

Association Between Length of Storage of Transfused Packed RBC Units and Outcome of Surgical Critically Ill Adults: A Subgroup Analysis of the Age of Blood Evaluation Randomized Trial  – Critical Care Medicine

Characteristics, therapies, and outcomes of In-Hospital vs Out-of-Hospital cardiac arrest in patients presenting to cardiac intensive care units: From the critical care Cardiology trials network (CCCTN)  – Resuscitation

Chlorthalidone vs. Hydrochlorothiazide for Hypertension–Cardiovascular Events – NEJM

Colistin Monotherapy versus Combination Therapy for Carbapenem-Resistant Organisms  – NEJM Evidence

Continuous peripheral nerve blocks for analgesia of ventilated critically ill patients with multiple trauma: a prospective randomized study  – Anaesthesia Critical Care & Pain Medicine

Effect of clinical peer review on mortality in patients ventilated for more than 24 hours: a cluster randomised controlled trial  – BMJ Quality and Safety

Effect of high-flow oxygen versus T-piece ventilation strategies during spontaneous breathing trials on weaning failure among patients receiving mechanical ventilation: a randomized controlled trial  – Critical Care

Evaluation of a closed loop-blood sampling system in intensive care: A pilot randomised controlled trial. The ENCLOSE trial  –  Intensive and Critical Care Nursing

Haloperidol for the Treatment of Delirium in ICU Patients – NEJM

Hemoperfusion for Clinically Suspected Organophosphate and Carbamate Poisoning in Critically Ill Patients: A Randomized Trial  – Blood Purification

Isoflurane vs. propofol for sedation in invasively ventilated patients with acute hypoxemic respiratory failure: an a priori hypothesis substudy of a randomized controlled trial  – Annals of Intensive Care

Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial  – JAMA

Mannitol for prevention of acute kidney injury after liver transplantation: a randomized controlled trial  – BMC Anesthesiology

Melatonin for prevention of acute kidney injury in patients treated with intravenous polymyxin B: a double-blind, placebo-controlled randomised clinical trial  – Clinical Microbiology and Infection

Non-interventional follow-up versus fluid bolus in RESPONSE to oliguria in hemodynamically stable critically ill patients: a randomized controlled pilot trial  – Critical Care

Outcomes in participants with failure of initial antibacterial therapy for hospital-acquired/ventilator-associated bacterial pneumonia prior to enrollment in the randomized, controlled phase 3 ASPECT-NP trial of ceftolozane/tazobactam versus meropenem  – Critical Care

Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia – NEJM

The effect of abdominal massage on enteral nutrition tolerance in patients on mechanical ventilation: A Randomized Controlled Study  – Intensive and Critical Care Nursing

The effects of a sensory stimulation intervention on psychosocial and clinical outcomes of critically ill patients and their families: A randomised controlled trial  – Intensive and Critical Care Nursing

Thromboelastometry-guided treatment algorithm in postpartum haemorrhage: a randomised, controlled pilot trial  – British Journal of Anaesthesia

Ultra-lung-protective ventilation and biotrauma in severe ARDS patients on veno-venous extracorporeal membrane oxygenation: a randomized controlled study  – Critical Care

Ultrasound-Guided Infraclavicular Axillary Vein Versus Internal Jugular Vein Cannulation in Critically Ill Mechanically Ventilated Patients: A Randomized Trial  – Critical Care Medicine

Other Guidance/Reports

2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade: A Report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade  – Anesthesiology

Canadian Stroke Best Practice Recommendations: Acute Stroke Management, 7th Edition Practice Guidelines Update, 2022  – Canadian Journal of Neurological Sciences

Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression  – Military Medical Research

Guidelines for Reporting Outcomes in Trial Protocols – The SPIRIT-Outcomes 2022 Extension  – JAMA

Randomized Trials Fit for the 21st Century: A Joint Opinion From the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation  – Journal of the American College of Cardiology

Primary Research

A multicentric prospective observational study of diagnosis and prognosis features in ICU mesenteric ischemia: the DIAGOMI study  – Annals of Intensive Care

A novel method to calculate compliance and airway resistance in ventilated patients  – Intensive Care Medicine Experimental

A prospective observational study on impact of epinephrine administration route on acute myocardial infarction patients with cardiac arrest in the catheterization laboratory (iCPR study)  – Critical Care

Abdominal atherosclerosis is not a risk factor of nonocclusive mesenteric ischemia among critically ill patients: a propensity matching study  – Annals of Intensive Care

Anemia before in-hospital cardiac arrest and survival from cardio-pulmonary resuscitation—a retrospective cohort study  – Journal of Anesthesia, Analgesia and Critical Care

Angiotensin II for Vasodilatory Hypotension in Patients Requiring Mechanical Circulatory Support  – Journal of Intensive Care Medicine

Assessment of Good Practice Guidelines for Administration of Drugs via Feeding Tubes by a Clinical Pharmacist in the Intensive Care Unit  – Critical Care Nurse

Association between age and the host response in critically ill patients with sepsis  – Critical Care

Association between cholinesterase activity and critical illness brain dysfunction  – Critical Care

“At the end, we are all human” – Striving for equity in the care of patients from culturally diverse backgrounds  – Intensive and Critical Care Nursing

Auto-antibodies against type I IFNs in > 10% of critically ill COVID-19 patients: a prospective multicentre study  – Annals of Intensive Care

Brain injury markers in blood predict signs of hypoxic ischaemic encephalopathy on head computed tomography after cardiac arrest  – Resuscitation

Cerebrovascular complications and outcomes of critically ill adult patients with infective endocarditis  – Annals of Intensive Care

Cerebrovascular pressure reactivity and brain tissue oxygen monitoring provide complementary information regarding the lower and upper limits of cerebral blood flow control in traumatic brain injury: a CAnadian High Resolution-TBI (CAHR-TBI) cohort study  – Intensive Care Medicine Experimental

Changing epidemiology of acute kidney injury in critically ill patients with COVID-19: a prospective cohort  – Annals of Intensive Care

Circular material flow in the intensive care unit—environmental effects and identification of hotspots  – Intensive Care Medicine

Comparing rehabilitation outcomes for patients admitted to the intensive care unit with COVID-19 requiring mechanical ventilation during the first two waves of the pandemic: A service evaluation  – Intensive and Critical Care Nursing

Coronavirus disease 2019 aftermath: psychological trauma in ICU healthcare workers  – Current Opinion in Critical Care

COVID-19-associated AKI  – Current Opinion in Critical Care

Critical Care and Postoperative Management of the First Human Long Segment Orthotopic Tracheal Transplantation  – Critical Care Explorations

Diaphragm Neurostimulation Mitigates Ventilation-Associated Brain Injury in a Preclinical Acute Respiratory Distress Syndrome Model  – Critical Care Explorations

Effect of Admission and Discharge Times on Hospital Mortality in Patients With Sepsis  – Critical Care Medicine

Effect of an educational intervention on compliance with care bundle items to prevent ventilator-associated pneumonia  – Intensive and Critical Care Nursing

Effects of changes in inspired oxygen fraction on urinary oxygen tension measurements  – Intensive Care Medicine Experimental

Examining the needs of survivors of critical illness through the lens of palliative care: A qualitative study of survivor experiences  – Intensive and Critical Care Nursing

Frailty is a stronger predictor of death in younger intensive care patients than in older patients: a prospective observational study  – Annals of Intensive Care

Gene signature for the prediction of the trajectories of sepsis-induced acute kidney injury  – Critical Care

Healthcare trajectory of critically ill patients with necrotizing soft tissue infections: a multicenter retrospective cohort study using the clinical data warehouse of Greater Paris University Hospitals  – Annals of Intensive Care

How do nurses manage their work under time pressure? Occurrence of implicit rationing of nursing care in the intensive care unit: A qualitative study  – Intensive and Critical Care Nursing

Improving ICU Risk Predictive Models Through Automation Designed for Resiliency Against Documentation Bias  – Critical Care Medicine

Intellectually disabled patients’ intensive care admission characteristics, weaning from mechanical ventilation, and sedative drug use: a single-center retrospective case-control study  – Journal of Anesthesia, Analgesia and Critical Care

Machine learning for the real-time assessment of left ventricular ejection fraction in critically ill patients: a bedside evaluation by novices and experts in echocardiography  – Critical Care

Management of transgender patients in critical care  – Journal of the Intensive Care Society

Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study  – Journal of Intensive Care

Mechanical ventilation variables associated with high pulmonary artery pressures in ARDS patients: a post hoc analysis  – Critical Care

Methods for calculating ventilation rates during resuscitation from out-of-hospital cardiac arrest  – Resuscitation

Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke  – Intensive Care Medicine Experimental

Modulation of inflammation by treatment with tocilizumab after out-of-hospital cardiac arrest and associations with clinical status, myocardial- and brain injury  – Resuscitation

Outcomes and Adverse Effects of Baricitinib Versus Tocilizumab in the Management of Severe COVID-19

Critical Care Medicine

Perioperative outcomes in intermediate and high-risk patients after major surgery following introduction of a dedicated perioperative medicine team: A single centre cohort study  – Anaesthesia and Intensive Care

Perspectives and wishes for patient and family centred care as expressed by adult intensive care survivors and family-members: A qualitative interview study  – Intensive and Critical Care Nursing

Physical, social, mental and spiritual functioning of COVID-19 intensive care unit-survivors and their family members one year after intensive care unit-discharge: A prospective cohort study  – Intensive and Critical Care Nursing

Prediction of noninvasive ventilation failure using the ROX index in patients with de novo acute respiratory failure  – Annals of Intensive Care

Predicting Readmission or Death After Discharge From the ICU: External Validation and Retraining of a Machine Learning Model  – Critical Care Medicine

Prognostic significance of delirium subtypes in critically ill medical and surgical patients: a secondary analysis of a prospective multicenter study  – Journal of Intensive Care

Real-time 4D transesophageal echocardiography in the evaluation of cardioaortic embolism: the value of completing a comprehensive protocol  – Intensive Care Medicine

Score-based prediction model for severe vitamin D deficiency in patients with critical illness: development and validation  – Critical Care

The effect of music on delirium, pain, sedation and anxiety in patients receiving mechanical ventilation in the intensive care unit  – Intensive and Critical Care Nursing

The Impact of Thoracic Ultrasound on Clinical Management of Critically Ill Patients (UltraMan): An International Prospective Observational Study  – Critical Care Medicine

The importance of nutrition to morbidity and mortality in critically ill patients  – Intensive and Critical Care Medicine

The prevalence of mental frailty in ICU survivors and informal caregiver strain: A 1-year retrospective study of the Frisian aftercare cohort  – Journal of the Intensive Care Society

Timing of tracheostomy and patient outcomes in critically ill patients requiring extracorporeal membrane oxygenation: a single-center retrospective observational study  – Journal of Intensive Care

Zone 1 Endovascular Balloon Occlusion of the Aorta vs Resuscitative Thoracotomy for Patient Resuscitation After Severe Hemorrhagic Shock  – JAMA Surgery


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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