Critical Care Evidence Updates – February 2024

Randomised Controlled Trials

Allogeneic Stem Cell Therapy for Acute Ischemic Stroke – The Phase 2/3 TREASURE Randomized Clinical Trial  JAMA Neurology

Alveolar Hemorrhage in ANCA-associated Vasculitis: Results of an International, Randomized, Controlled Trial (PEXIVAS)  American Journal of Respiratory and Critical Care Medicine

Association of Shock Indices with Peri-Intubation Hypotension and Other Outcomes: A Sub-Study of the KEEP PACE Trial  Journal of Intensive Care Medicine

Blood volume and hemodynamics during treatment of major hemorrhage with Ringer solution, 5% albumin, and 20% albumin: a single-center randomized controlled trial  Critical Care

Catastrophic Streptococcus pyogenes Disease: A Personalized Approach Based on Phenotypes and Treatable Traits  Antibiotics

Continuous vs intermittent Non-Invasive blood pressure MONitoring in preventing postoperative organ failure (niMON): study protocol for an open-label, multicenter randomized trial  Journal of Anesthesia, Analgesia and Critical Care

Control of mean arterial pressure using a closed-loop system for norepinephrine infusion in severe brain injury patients: the COMAT randomized controlled trial  Journal of Clinical Monitoring and Computing

Decurarization After Thoracic Anesthesia using sugammadex compared to neostigmine (DATA trial): a multicenter randomized double-blinded controlled trial  Journal of Anesthesia, Analgesia and Critical Care

Early Mobilization Using a Mobile Patient Lift in the ICU: A Randomized Controlled Trial  Critical Care Medicine

Effect of aggressive vs conservative screening and confirmatory test on time to extubation among patients at low or intermediate risk: a randomized clinical trial  Intensive Care Medicine

Hydrocortisone plus fludrocortisone for community acquired pneumonia-related septic shock: a subgroup analysis of the APROCCHSS phase 3 randomised trial   The Lancet Respiratory Medicine

In-person peer support for critical care survivors: The ICU REcovery Solutions cO-Led through surVivor Engagement (ICURESOLVE) pilot randomised controlled trial  Australian Critical Care

Methylprednisolone as Adjunct to Endovascular Thrombectomy for Large-Vessel Occlusion Stroke   The MARVEL Randomized Clinical Trial  JAMA

Nebulized Furosemide for Pulmonary Inflammation in Intubated Patients With COVID-19: A Phase 2 Randomized Controlled Double-Blind Study  Critical Care Explorations

Postprocedural Anticoagulation After Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction: A Multicenter, Randomized, Double-Blind Trial  Circulation

Racial Differences in Shared Decision-Making About Critical Illness  JAMA Internal Medicine

Renal replacement therapy initiation strategies in comatose patients with severe acute kidney injury: a secondary analysis of a multicenter randomized controlled trial   Intensive Care Medicine

Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection   NEJM

The use of ExPreS – Extubation Predictive Score – in the weaning of patients in mechanical ventilation: a randomized clinical trial  ERJ Open Research

Therapeutic Hypothermia in Low-Risk Nonpumped Brain-Dead Kidney Donors – A Randomized Clinical Trial  JAMA Network Open

Thiamine as a Metabolic Resuscitator after Out-of-hospital Cardiac Arrest – RCT  Resuscitation

Other Guidance/Reports

Cardiogenic Shock in Older Adults: A Focus on Age-Associated Risks and Approach to Management: A Scientific Statement From the American Heart Association  Circulation

Consensus statement on the management of hyperkalaemia—An Asia–Pacific perspective  Nephrology

Dyspnoea in acutely ill mechanically ventilated adult patients: an ERS/ESICM statement  Intensive Care Medicine

EACTS/STS Guidelines for diagnosing and treating acute and chronic syndromes of the aortic organ  European Journal of Cardio-Thoracic Surgery

ESPEN practical short micronutrient guideline  Clinical Nutrition

European Association of Cardio-Thoracic Surgery (EACTS) expert consensus statement on perioperative myocardial infarction after cardiac surgery  European Journal of Cardio-Thoracic Surgery

Guidelines for Neuroprognostication in Critically Ill Adults with Moderate–Severe Traumatic Brain Injury  Neurocritical Care

Indian Society of Critical Care Medicine and Indian Association of Palliative Care Expert Consensus and Position Statements for End of Life and Palliative Care in the Intensive Care Unit  Indian Society of Critical Care Medicine

Recommendations from the Brazilian Society of Anesthesiology (SBA) for difficult airway management in adults  Brazilian Journal of Anesthesiology

Primary Research

A Case Series of Patients With Complex Airway Disease and Large Thyroid Tumors Anterior to the Trachea Precluding Tracheostomy  Critical Care Explorations

A novel structured debriefing program for consensus determinations of in-hospital cardiac arrest predictability and preventability  Resuscitation

A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome  Nature Communications

Albumin versus saline infusion for sepsis-related peripheral tissue hypoperfusion: a proof-of-concept prospective study  Critical Care

Antibiotic definitive treatment in ventilator associated pneumonia caused by AmpC-producing Enterobacterales in critically ill patients: a prospective multicenter observational study  Critical Care

Arterial graft cannulation for extracorporeal cardiopulmonary resuscitation  Intensive Care Medicine

Association of Body Mass Index with Multiple Organ Failure in Hospitalized Patients with COVID-19: A Multicenter Retrospective Cohort Study  Journal of Intensive Care Medicine

Associations Between Family-Assessed Quality-of-Dying-and-Death Latent Classes and Bereavement Outcomes for Family Surrogates of ICU Decedents  Critical Care Medicine

Automated characterization of patient–ventilator interaction using surface electromyography  Annals of Intensive Care

Barriers and Facilitators to End-of-Life Care Delivery in ICUs: A Qualitative Study  Critical Care Medicine

Bioimpedance-assessed muscle wasting and its relation to nutritional intake during the first week of ICU: a pre-planned secondary analysis of Nutriti Study  Annals of Intensive Care

Cerebral autoregulation-directed optimal blood pressure management reduced the risk of delirium in patients with septic shock  Journal of Intensive Medicine

Coexistence of a fluid responsive state and venous congestion signals in critically ill patients: a multicenter observational proof-of-concept study  Critical Care

Comparing Simulation Training of Bronchoscopy-Guided Percutaneous Dilatational Tracheostomy Using Conventional Versus 3D Printed Simulators (TRAC-Sim Study)  Journal of Intensive Care Medicine

Comprehensive temporal analysis of right ventricular function and pulmonary haemodynamics in mechanically ventilated COVID-19 ARDS patients  Annals of Intensive Care

Critically ill patients with infective endocarditis, neurological complications and indication for cardiac surgery: a multicenter propensity-adjusted study  Annals of Intensive Care

Deimplementation of Gastric Residual Volume Monitoring to Enhance Patient Nutrition  Critical Care Nurse

Effect of Age of Transfused Red Blood Cell Units on Clinical Outcomes in Critically Ill Patients  Indian Journal of Hematology and Blood Transfusion

Effect of Increasing Blood Pressure on Brain Tissue Oxygenation in Adults After Severe Traumatic Brain Injury   Critical Care Medicine

Efficacy and Safety of Nirmatrelvir/Ritonavir in Severe Hospitalized Patients with COVID-19 and in Patients at High Risk for Progression to Critical Illness: A Real-World Study   Journal of Intensive Care Medicine

Estimation of the effect of vaccination in critically ill COVID-19 patients, analysis using propensity score matching  Annals of Intensive Care

Evaluation of levetiracetam dosing for seizure prophylaxis in traumatic brain injury  Trauma

Evolution of Clinical Characteristics and Outcomes of Critically Ill Patients 90 Years Old or Older Over a 12-Year Period: A Retrospective Cohort Study  Critical Care Medicine

Exploring the therapeutic role of early heparin administration in ARDS management: a MIMIC-IV database analysis  Journal of Intensive Care

External validation of the HACOR score and ROX index for predicting treatment failure in patients with coronavirus disease 2019 pneumonia managed on high-flow nasal cannula therapy: a multicenter retrospective observational study in Japan   Journal of Intensive Care

Healthcare-associated infections in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study  Critical Care

Immediate vs. culture-initiated antibiotic therapy in suspected non-severe ventilator-associated pneumonia: a before–after study (DELAVAP)  Annals of Intensive Care

Impact of dexamethasone in severe COVID-19-induced acute kidney injury: a multicenter cohort study  Annals of Intensive Care

Impact of Lactate Clearance on Clinical and Neurological Outcomes of Patients With Out-of-Hospital Cardiac Arrest Treated With Extracorporeal Cardiopulmonary Resuscitation: A Secondary Data Analysis  Critical Care Medicine

Incidence and risk factors of peripheral nerve injuries 3 months after ICU discharge: a retrospective study comparing COVID-19 and non-COVID-19 critically ill survivors  Journal of Anesthesia, Analgesia and Critical Care

Intubation Decision Based on Illness Severity and Mortality in COVID-19: An International Study  Critical Care Medicine

Ketamine for Primary Analgosedation in Critically Ill Surgery and Trauma Patients Requiring Mechanical Ventilation  Critical Care Explorations

Long-stay ICU patients with frailty: mortality and recovery outcomes at 6 months  Annals of Intensive Care

Management of Immunosuppressive Therapy in Kidney Transplant Recipients with Sepsis: A Multicenter Retrospective Study  Journal of Intensive Care Medicine

Nephrotoxic Risk Associated With Combination Therapy of Vancomycin and Piperacillin-Tazobactam in Critically Ill Patients With Chronic Kidney Disease  Journal of Intensive Care Medicine

Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial  Critical Care

Nurse-Driven Fluid Responsiveness Evaluation in Patients With Septic Shock: A Quality Improvement Initiative  Critical Care Nurse

Potential of acetaminophen on the sublingual microcirculation and peripheral tissue perfusion of febrile septic patients: prospective observational study  Annals of Intensive Care

Prediction of esophagogastroduodenoscopy therapeutic usefulness for in-ICU suspected upper gastrointestinal bleeding: the SUGIBI score study   Annals of Intensive Care

Prevalence and Survival of Prolonged Venovenous Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome: An Analysis of the Extracorporeal Life Support Organization Registry   Critical Care Medicine

Real-World Implications of Updated Surviving Sepsis Campaign Antibiotic Timing Recommendations  Critical Care Medicine

Reintubation Rate and Mortality After Emergent Airway Management Outside the Operating Room   Journal of Intensive Care Medicine

Screening for Alcohol Use Disorder and Management of Alcohol Withdrawal Syndrome in Critical Care Patients  Critical Care Nurse

Study of Empiric Antibiotic Prescription Patterns and Microbiological Isolates in Hemodynamically Stable and Unstable ICU Patients With Community-Acquired Sepsis  Journal of Intensive Care Medicine

The association between mechanical CPR and outcomes from in-hospital cardiac arrest: An observational cohort study  Resuscitation

The Effect of Albumin Administration in Critically Ill Patients: A Retrospective Single-Center Analysis  Critical Care Medicine

The environmental impact of laboratory measurements in high-resource ICUs  Intensive Care Medicine

The Impact of Fluid Balance on Acute Kidney Injury in Nontraumatic Subarachnoid Hemorrhage  Journal of Intensive Care Medicine

The use of extracorporeal blood purification therapies and sequential extracorporeal support in patients with septic shock (EROICASS): a study protocol for a national, non-interventional, observational multicenter, prospective study  Journal of Anesthesia, Analgesia and Critical Care

Unit-to-unit transfer due to shortage of intensive care beds in Sweden 2015–2019 was associated with a lower risk of death but a longer intensive care stay compared to no transfer: a registry study  Journal of Intensive Care

Validation of a low-cost continuous renal replacement therapy dialysate fluid controller for experimental purposes  Intensive Care Medicine Experimental

Vasoconstriction in septic shock  Intensive Care Medicine



Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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