Critical Care Evidence Updates – February 2024
Randomised Controlled Trials
Allogeneic Stem Cell Therapy for Acute Ischemic Stroke – The Phase 2/3 TREASURE Randomized Clinical Trial JAMA Neurology
Alveolar Hemorrhage in ANCA-associated Vasculitis: Results of an International, Randomized, Controlled Trial (PEXIVAS) American Journal of Respiratory and Critical Care Medicine
Association of Shock Indices with Peri-Intubation Hypotension and Other Outcomes: A Sub-Study of the KEEP PACE Trial Journal of Intensive Care Medicine
Continuous vs intermittent Non-Invasive blood pressure MONitoring in preventing postoperative organ failure (niMON): study protocol for an open-label, multicenter randomized trial Journal of Anesthesia, Analgesia and Critical Care
Control of mean arterial pressure using a closed-loop system for norepinephrine infusion in severe brain injury patients: the COMAT randomized controlled trial Journal of Clinical Monitoring and Computing
Decurarization After Thoracic Anesthesia using sugammadex compared to neostigmine (DATA trial): a multicenter randomized double-blinded controlled trial Journal of Anesthesia, Analgesia and Critical Care
Early Mobilization Using a Mobile Patient Lift in the ICU: A Randomized Controlled Trial Critical Care Medicine
Effect of aggressive vs conservative screening and confirmatory test on time to extubation among patients at low or intermediate risk: a randomized clinical trial Intensive Care Medicine
Hydrocortisone plus fludrocortisone for community acquired pneumonia-related septic shock: a subgroup analysis of the APROCCHSS phase 3 randomised trial The Lancet Respiratory Medicine
In-person peer support for critical care survivors: The ICU REcovery Solutions cO-Led through surVivor Engagement (ICURESOLVE) pilot randomised controlled trial Australian Critical Care
Methylprednisolone as Adjunct to Endovascular Thrombectomy for Large-Vessel Occlusion Stroke The MARVEL Randomized Clinical Trial JAMA
Nebulized Furosemide for Pulmonary Inflammation in Intubated Patients With COVID-19: A Phase 2 Randomized Controlled Double-Blind Study Critical Care Explorations
Racial Differences in Shared Decision-Making About Critical Illness JAMA Internal Medicine
Renal replacement therapy initiation strategies in comatose patients with severe acute kidney injury: a secondary analysis of a multicenter randomized controlled trial Intensive Care Medicine
Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection NEJM
The use of ExPreS – Extubation Predictive Score – in the weaning of patients in mechanical ventilation: a randomized clinical trial ERJ Open Research
Therapeutic Hypothermia in Low-Risk Nonpumped Brain-Dead Kidney Donors – A Randomized Clinical Trial JAMA Network Open
Thiamine as a Metabolic Resuscitator after Out-of-hospital Cardiac Arrest – RCT Resuscitation
Other Guidance/Reports
Consensus statement on the management of hyperkalaemia—An Asia–Pacific perspective Nephrology
Dyspnoea in acutely ill mechanically ventilated adult patients: an ERS/ESICM statement Intensive Care Medicine
EACTS/STS Guidelines for diagnosing and treating acute and chronic syndromes of the aortic organ European Journal of Cardio-Thoracic Surgery
ESPEN practical short micronutrient guideline Clinical Nutrition
European Association of Cardio-Thoracic Surgery (EACTS) expert consensus statement on perioperative myocardial infarction after cardiac surgery European Journal of Cardio-Thoracic Surgery
Guidelines for Neuroprognostication in Critically Ill Adults with Moderate–Severe Traumatic Brain Injury Neurocritical Care
Indian Society of Critical Care Medicine and Indian Association of Palliative Care Expert Consensus and Position Statements for End of Life and Palliative Care in the Intensive Care Unit Indian Society of Critical Care Medicine
Recommendations from the Brazilian Society of Anesthesiology (SBA) for difficult airway management in adults Brazilian Journal of Anesthesiology
Primary Research
A Case Series of Patients With Complex Airway Disease and Large Thyroid Tumors Anterior to the Trachea Precluding Tracheostomy Critical Care Explorations
A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome Nature Communications
Albumin versus saline infusion for sepsis-related peripheral tissue hypoperfusion: a proof-of-concept prospective study Critical Care
Arterial graft cannulation for extracorporeal cardiopulmonary resuscitation Intensive Care Medicine
Association of Body Mass Index with Multiple Organ Failure in Hospitalized Patients with COVID-19: A Multicenter Retrospective Cohort Study Journal of Intensive Care Medicine
Associations Between Family-Assessed Quality-of-Dying-and-Death Latent Classes and Bereavement Outcomes for Family Surrogates of ICU Decedents Critical Care Medicine
Automated characterization of patient–ventilator interaction using surface electromyography Annals of Intensive Care
Barriers and Facilitators to End-of-Life Care Delivery in ICUs: A Qualitative Study Critical Care Medicine
Bioimpedance-assessed muscle wasting and its relation to nutritional intake during the first week of ICU: a pre-planned secondary analysis of Nutriti Study Annals of Intensive Care
Cerebral autoregulation-directed optimal blood pressure management reduced the risk of delirium in patients with septic shock Journal of Intensive Medicine
Comparing Simulation Training of Bronchoscopy-Guided Percutaneous Dilatational Tracheostomy Using Conventional Versus 3D Printed Simulators (TRAC-Sim Study) Journal of Intensive Care Medicine
Comprehensive temporal analysis of right ventricular function and pulmonary haemodynamics in mechanically ventilated COVID-19 ARDS patients Annals of Intensive Care
Critically ill patients with infective endocarditis, neurological complications and indication for cardiac surgery: a multicenter propensity-adjusted study Annals of Intensive Care
Deimplementation of Gastric Residual Volume Monitoring to Enhance Patient Nutrition Critical Care Nurse
Effect of Age of Transfused Red Blood Cell Units on Clinical Outcomes in Critically Ill Patients Indian Journal of Hematology and Blood Transfusion
Effect of Increasing Blood Pressure on Brain Tissue Oxygenation in Adults After Severe Traumatic Brain Injury Critical Care Medicine
Efficacy and Safety of Nirmatrelvir/Ritonavir in Severe Hospitalized Patients with COVID-19 and in Patients at High Risk for Progression to Critical Illness: A Real-World Study Journal of Intensive Care Medicine
Estimation of the effect of vaccination in critically ill COVID-19 patients, analysis using propensity score matching Annals of Intensive Care
Evaluation of levetiracetam dosing for seizure prophylaxis in traumatic brain injury Trauma
Evolution of Clinical Characteristics and Outcomes of Critically Ill Patients 90 Years Old or Older Over a 12-Year Period: A Retrospective Cohort Study Critical Care Medicine
Exploring the therapeutic role of early heparin administration in ARDS management: a MIMIC-IV database analysis Journal of Intensive Care
Immediate vs. culture-initiated antibiotic therapy in suspected non-severe ventilator-associated pneumonia: a before–after study (DELAVAP) Annals of Intensive Care
Impact of dexamethasone in severe COVID-19-induced acute kidney injury: a multicenter cohort study Annals of Intensive Care
Impact of Lactate Clearance on Clinical and Neurological Outcomes of Patients With Out-of-Hospital Cardiac Arrest Treated With Extracorporeal Cardiopulmonary Resuscitation: A Secondary Data Analysis Critical Care Medicine
Incidence and risk factors of peripheral nerve injuries 3 months after ICU discharge: a retrospective study comparing COVID-19 and non-COVID-19 critically ill survivors Journal of Anesthesia, Analgesia and Critical Care
Intubation Decision Based on Illness Severity and Mortality in COVID-19: An International Study Critical Care Medicine
Ketamine for Primary Analgosedation in Critically Ill Surgery and Trauma Patients Requiring Mechanical Ventilation Critical Care Explorations
Long-stay ICU patients with frailty: mortality and recovery outcomes at 6 months Annals of Intensive Care
Management of Immunosuppressive Therapy in Kidney Transplant Recipients with Sepsis: A Multicenter Retrospective Study Journal of Intensive Care Medicine
Nephrotoxic Risk Associated With Combination Therapy of Vancomycin and Piperacillin-Tazobactam in Critically Ill Patients With Chronic Kidney Disease Journal of Intensive Care Medicine
Nurse-Driven Fluid Responsiveness Evaluation in Patients With Septic Shock: A Quality Improvement Initiative Critical Care Nurse
Potential of acetaminophen on the sublingual microcirculation and peripheral tissue perfusion of febrile septic patients: prospective observational study Annals of Intensive Care
Prediction of esophagogastroduodenoscopy therapeutic usefulness for in-ICU suspected upper gastrointestinal bleeding: the SUGIBI score study Annals of Intensive Care
Prevalence and Survival of Prolonged Venovenous Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome: An Analysis of the Extracorporeal Life Support Organization Registry Critical Care Medicine
Real-World Implications of Updated Surviving Sepsis Campaign Antibiotic Timing Recommendations Critical Care Medicine
Reintubation Rate and Mortality After Emergent Airway Management Outside the Operating Room Journal of Intensive Care Medicine
Screening for Alcohol Use Disorder and Management of Alcohol Withdrawal Syndrome in Critical Care Patients Critical Care Nurse
Study of Empiric Antibiotic Prescription Patterns and Microbiological Isolates in Hemodynamically Stable and Unstable ICU Patients With Community-Acquired Sepsis Journal of Intensive Care Medicine
The association between mechanical CPR and outcomes from in-hospital cardiac arrest: An observational cohort study Resuscitation
The Effect of Albumin Administration in Critically Ill Patients: A Retrospective Single-Center Analysis Critical Care Medicine
The environmental impact of laboratory measurements in high-resource ICUs Intensive Care Medicine
The Impact of Fluid Balance on Acute Kidney Injury in Nontraumatic Subarachnoid Hemorrhage Journal of Intensive Care Medicine
The use of extracorporeal blood purification therapies and sequential extracorporeal support in patients with septic shock (EROICASS): a study protocol for a national, non-interventional, observational multicenter, prospective study Journal of Anesthesia, Analgesia and Critical Care
Unit-to-unit transfer due to shortage of intensive care beds in Sweden 2015–2019 was associated with a lower risk of death but a longer intensive care stay compared to no transfer: a registry study Journal of Intensive Care
Validation of a low-cost continuous renal replacement therapy dialysate fluid controller for experimental purposes Intensive Care Medicine Experimental
Vasoconstriction in septic shock Intensive Care Medicine
Metadata
Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash
This critical care evidence update for February 2024 is a valuable resource for healthcare professionals, offering a concise summary of recent research findings. It serves as a timely aid in staying abreast of the latest developments in critical care medicine. Kudos to The Bottom Line team for their dedication to disseminating evidence-based knowledge and facilitating informed clinical decision-making.