Critical Care Evidence Updates – January 2024

Randomised Controlled Trials

Antipsychotics and the QTc Interval During Delirium in the Intensive Care Unit

A Secondary Analysis of a Randomized Clinical Trial  JAMA Network Open

Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury: a multicentre, randomised, double-blind, placebo-controlled, assessor-masked superiority trial  The Lancet Respiratory Medicine

Clarithromycin for early anti-inflammatory responses in community-acquired pneumonia in Greece (ACCESS): a randomised, double-blind, placebo-controlled trial  The Lancet Respiratory Medicine

Combined effects of targeted blood pressure, oxygenation, and duration of device-based fever prevention after out-of-hospital cardiac arrest on 1-year survival: post hoc analysis of a randomized controlled trial  Critical Care

Default Palliative Care Consultation for Seriously Ill Hospitalized Patients

A Pragmatic Cluster Randomized Trial  JAMA

Early prediction of sepsis in intensive care patients using the machine learning algorithm NAVOY® Sepsis, a prospective randomized clinical validation study  Journal of Critical Care

Effect of intubation in lateral position on placement of a double-lumen tube in patients undergoing unilateral video-assisted thoracic surgery: a randomied clinical trial  eClinicalMedicine

Effects of Vibration Therapy on the Physical Function of Critically Ill Adults Trial: A Randomized Controlled Trial  Critical Care Medicine

Efficacy and safety of a structured de-escalation from antipseudomonal β-lactams in bloodstream infections due to Enterobacterales (SIMPLIFY): an open-label, multicentre, randomised trial  The Lancet Infectious Diseases

Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial  The Lancet Infectious Diseases

Enhanced exclusive enteral nutrition delivery during the first 7 days is associated with decreased 28-day mortality in critically ill patients with normal lactate level: a post hoc analysis of a multicenter randomized trial  Critical Care

Extracorporeal Carbon Dioxide Removal to Avoid Invasive Ventilation During Exacerbations of Chronic Obstructive Pulmonary Disease: VENT-AVOID Trial  American Journal of Respiratory and Critical Care Medicine

Gas Humidification During Helmet Continuous Positive Airway Pressure – A Crossover Randomized Physiologic Study in Healthy Subjects  Dimensions of Critical Care Nursing

Individualised, short-course antibiotic treatment versus usual long-course treatment for ventilator-associated pneumonia (REGARD-VAP): a multicentre, individually randomised, open-label, non-inferiority trial  The Lancet Respiratory Medicine

Mobile Application–Based Communication Facilitation Platform for Family Members of Critically Ill Patients

A Randomized Clinical Trial  JAMA Network Open

Mobile Critical Care Recovery Program for Survivors of Acute Respiratory Failure

A Randomized Clinical Trial  JAMA Network Open

Morphine for treatment of cough in idiopathic pulmonary fibrosis (PACIFY COUGH): a prospective, multicentre, randomised, double-blind, placebo-controlled, two-way crossover trial  The Lancet Respiratory Medicine

Perspectives of ICU Patients on Deferred Consent in the Context of Post-ICU Quality of Life: A Substudy of a Randomized Clinical Trial  Critical Care Medicine

Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)  Intensive Care Medicine

Remote ischemic conditioning reduces adverse events in patients with acute ischemic stroke complicating acute myocardial infarction: a randomized controlled trial  Critical Care

Sudarshan Kriya Yoga Breathing and a Meditation Program for Burnout Among Physicians

A Randomized Clinical Trial  JAMA Network Open

The effect of computerised decision support alerts tailored to intensive care on the administration of high-risk drug combinations, and their monitoring: a cluster randomised stepped-wedge trial  The Lancet

The effect of high-flow oxygen via tracheostomy on respiratory pattern and diaphragmatic function in patients with prolonged mechanical ventilation: A randomized, physiological, crossover study  Journal of Intensive Medicine

Videolaryngoscope versus Conventional Technique for Insertion of a Transesophageal Echocardiography Probe in Intubated ICU Patients (VIDLARECO trial). A Randomized Clinical trial  Anaesthesia Critical Care & Pain Medicine


Artificial intelligence (AI)-derived software to help clinical decision making in stroke DG57

COVID-19 rapid guideline: managing COVID-19 NG191

Temperature control to improve neurological outcomes after cardiac arrest IPG782

Suspected sepsis: recognition, diagnosis and early management NG51

Other Guidance/Reports

2024 Focused Update: Guidelines on Use of Corticosteroids in Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia  Critical Care Medicine

Diagnosis and Management of Cerebral Venous Thrombosis: A Scientific Statement From the American Heart Association  Stroke

Drug-Induced Liver Injury in the Elderly: Consensus Statements and Recommendations from the IQ-DILI Initiative  Drug Safety

Early management of adult traumatic spinal cord injury in patients with polytrauma: a consensus and clinical recommendations jointly developed by the World Society of Emergency Surgery (WSES) & the European Association of Neurosurgical Societies (EANS)  World Journal of Emergency Surgery

Improving eye care in an intensive care unit  Journal of the Intensive Care Society

Mastering the brain in critical conditions: an update  Intensive Care Medicine Experimental

Patient blood management guideline for adults with critical bleeding  Medical Journal of Australia

Position Paper on the Reporting of Norepinephrine Formulations in Critical Care from the Society of Critical Care Medicine and European Society of Intensive Care Medicine Joint Task Force  Critical Care Medicine

Society of Critical Care Medicine Guidelines on Glycemic Control for Critically Ill Children and Adults 2024  Critical Care Medicine

Society of Critical Care Medicine Guidelines on Recognizing and Responding to Clinical Deterioration Outside the ICU: 2023  Critical Care Medicine

Ten reasons for the presence of pharmacy professionals in the intensive care unit  Intensive Care Medicine

Value Creation Through Artificial Intelligence and Cardiovascular Imaging: A Scientific Statement From the American Heart Association  Circulation

Primary Research

A nomogram based on quantitative EEG to predict the prognosis of nontraumatic coma patients in the neuro-intensive care unit  Intensive and Critical Care Nursing

A retrospective analysis of carbapenem-resistant Acinetobacter baumannii infections in critically ill patients: Experience at a tertiary-care teaching hospital ICU  Journal of Intensive Medicine

Accuracy of Noninvasive Blood Pressure Monitoring in Critically Ill Adults  Journal of Intensive Care Medicine

 Acute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial  Intensive Care Medicine

Association between urea trajectory and protein dose in critically ill adults: a secondary exploratory analysis of the effort protein trial (RE-EFFORT)  Critical Care

Associations Between Inactivity and Cognitive Function in Older Intensive Care Unit Survivors  Dimensions of Critical Care Nursing

Bedside personalized methods based on electrical impedance tomography or respiratory mechanics to set PEEP in ARDS and recruitment-to-inflation ratio: a physiologic study  Annals of Intensive Care

Cerebral autoregulation in traumatic brain injury: ultra-low-frequency pressure reactivity index and intracranial pressure across age groups  Critical Care

Characteristics and Clinical Prognosis of Septic Patients With Persistent Lymphopenia  Journal of Intensive Care Medicine

Clinical and molecular epidemiological features of critically ill patients with invasive group A Streptococcus infections: a Belgian multicenter case-series  Annals of Intensive Care

Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study  Intensive Care Medicine

Compliance with cardiopulmonary resuscitation guidelines in witnessed in-hospital cardiac arrest events and patient outcome on monitored versus non-monitored wards  Resuscitation

Current clinical practice in using adjunctive extracorporeal blood purification in sepsis and septic shock: results from the ESICM “EXPLORATION” survey  Intensive Care Medicine Experimental

Development of quality indicators for palliative care in intensive care units and pilot testing them via electronic medical record review  Journal of Intensive Care

Diagnostic Errors in Hospitalized Adults Who Died or Were Transferred to Intensive Care  JAMA Internal Medicine

Does inflammation and altered metabolism impede efficacy of functional electrical stimulation in critically ill patients? Unleashing the potential of individualized functional electrical stimulation-cycling in critical illness  Critical Care

Driving pressure of respiratory system and lung stress in mechanically ventilated patients with active breathing  Critical Care

Early Autocalibrated Arterial Waveform Analysis for the Management of Burn Shock—A Cohort Study  Journal of Intensive Care Medicine

Effect of prehospital high-dose glucocorticoid on hemodynamics in patients resuscitated from out-of-hospital cardiac arrest: a sub-study of the STEROHCA trial  Critical Care

Effects on mechanical power of different devices used for inhaled sedation in a bench model of protective ventilation in ICU  Annals of Intensive Care

Exploring the recovery journey of COVID-19 critical care survivors during the first year after hospital discharge  Journal of the Intensive Care Society

Feasibility of Setting the Tidal Volume Based on End-Expiratory Lung Volume: A Pilot Clinical Study  Critical Care Explorations

Features and outcomes of patients admitted to the ICU for chimeric antigen receptor T cell-related toxicity: a French multicentre cohort  Annals of Intensive Care

Gut mycobiome dysbiosis after sepsis and trauma  Critical Care

Impact of COVID-19 on Quality of Life After Hospital Discharge in Patients Treated With Noninvasive Ventilation/Continuous Positive Airway Pressure – An Observational, Prospective Multicenter Study  Dimensions of Critical Care Nursing

Impact of Sedation Practices on Mortality in COVID-19-Associated Adult Respiratory Distress Syndrome Patients: A Multicenter Retrospective Descriptive Study  Journal of Intensive Care Medicine

Improving Outcomes in Mechanically Ventilated Adult ICU Patients Following Implementation of the ICU Liberation (ABCDEF) Bundle Across a Large Healthcare System  Critical Care Explorations

Incidence, diagnosis, management and outcome of acute mesenteric ischaemia: a prospective, multicentre observational study (AMESI Study)  Critical Care

Intensive care following in-hospital cardiac arrest / periarrest calls—experience from one Scottish hospital  Journal of Anesthesia, Analgesia and Critical Care

Invasive group A streptococcal infections requiring admission to ICU: a nationwide, multicenter, retrospective study (ISTRE study)  Critical Care

Ketamine for Primary Analgosedation in Critically Ill Surgery and Trauma Patients Requiring Mechanical Ventilation  Critical Care Explorations

Limitation of life sustaining measures in neurocritical care: sex, timing, and advance directive  Journal of Intensive Care

Long-Term Mortality and Health-Related Quality of Life After Continuous Versus Intermittent Renal Replacement Therapy in ICU Survivors: A Secondary Analysis of the Quality of Life After ICU Study  Journal of Intensive Care Medicine

Long term outcomes in the critically ill: Investigating the association between frailty and survival. LONG a SWARM regional observational study  Journal of the Intensive Care Society

Long-term outcomes with haloperidol versus placebo in acutely admitted adult ICU patients with delirium  Intensive Care Medicine

Postarrest Care Bundle Improves Quality of Care and Clinical Outcomes in the Normothermia Era  Journal of Intensive Care Medicine

Prevalence of Delirium After Abdominal Surgery and Association With Ketamine: A Retrospective, Propensity-Matched Cohort Study  Critical Care Explorations

Prognostic evaluation of quick sequential organ failure assessment score in ICU patients with sepsis across different income settings  Critical Care

Right ventricular injury in critically ill patients with COVID-19: a descriptive study with standardized echocardiographic follow-up  Annals of Intensive Care

Risk factors and mortality rates of carbapenem-resistant Gram-negative bacterial infections in intensive care units  Journal of Intensive Medicine

Risk factors for bleeding complications in patients undergoing extracorporeal cardiopulmonary resuscitation following out-of-hospital cardiac arrest: a secondary analysis of the SAVE-J II study  Annals of Intensive Care

ROX index performance to predict high-flow nasal oxygen outcome in Covid-19 related hypoxemic acute respiratory failure  Annals of Intensive Care

Safety and Efficacy of Reduced-Dose Versus Full-Dose Alteplase for Acute Pulmonary Embolism: A Multicenter Observational Comparative Effectiveness Study  Critical Care Medicine

Simultaneous Venous-Arterial Doppler Ultrasound During Early Fluid Resuscitation to Characterize a Novel Doppler Starling Curve: A Prospective Observational Pilot Study  Journal of Intensive Care Medicine

Single-drug versus combination antimicrobial therapy in critically ill patients with hospital-acquired pneumonia and ventilator-associated pneumonia due to Gram-negative pathogens: a multicenter retrospective cohort study  Critical Care

The Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal Compared With Conventional Lung Protective Ventilation on Cardiac Function  Critical Care Explorations

The effect of passive leg raising test on intracranial pressure and cerebral autoregulation in brain injured patients: a physiological observational study  Critical Care

The Impact of Nursing Education on Ventilator-Associated Pneumonia Prevention Bundle to Reduce Incidence of Infection: A Quality Improvement Project  Dimensions of Critical Care Nursing

Venous thromboembolism in critically ill adult patients with hematologic malignancy: a population-based cohort study  Intensive Care Medicine


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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