Critical Care Evidence Updates – July 2023

Randomised Controlled Trials

Abatacept, Cenicriviroc, or Infliximab for Treatment of Adults Hospitalized With COVID-19 Pneumonia A Randomized Clinical Trial   JAMA

Controlled enteral nutrition in critical care patients – A randomized clinical trial of a novel management system   Clinical Nutrition

Effects of a swallowing and oral-care program on resuming oral feeding and reducing pneumonia in patients following endotracheal extubation: a randomized, open-label, controlled trial   Critical Care

Effects of intraoperative inspired oxygen fraction (FiO2 0.3 vs 0.8) on patients undergoing off-pump coronary artery bypass grafting: the CARROT multicenter, cluster-randomized trial   Critical Care

Goal-directed Perioperative Albumin Substitution Versus Standard of Care to Reduce Postoperative Complications – A Randomized Clinical Trial (SuperAdd Trial)   Annals of Surgery

Intravenous vitamin C for vasoplegia: A double-blinded randomised clinical trial (VALENCIA trial)  Journal of Critical Care

Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest   NEJM

Prevention of urinary tract infection using a silver alloy hydrogel-coated catheter in critically ill patients: A single-center prospective randomized controlled study   Journal of Intensive Medicine

Safety and efficacy of artesunate treatment in severely injured patients with traumatic hemorrhage. The TOP-ART randomized clinical trial   Intensive Care Medicine

Spiked Helmet Sign in the Inferior Leads   JAMA Internal Medicine

The Effects of Peroxisome Proliferator-Activated Receptor-Delta Modulator ASP1128 in Patients at Risk for Acute Kidney Injury Following Cardiac Surgery   Kidney International Reports

The Restrictive Red Blood Cell Transfusion Strategy for Critically Injured Patients (RESTRIC) trial: a cluster-randomized, crossover, non-inferiority multicenter trial of restrictive transfusion in trauma   Journal of Intensive Care

Tranexamic Acid for Intracerebral Hemorrhage in Patients on Non-Vitamin K Antagonist Oral Anticoagulants (TICH-NOAC): A Multicenter, Randomized, Placebo-Controlled, Phase 2 Trial   Stroke

Ultra-low tidal volume ventilation for COVID-19-related ARDS in France (VT4COVID): a multicentre, open-label, parallel-group, randomised trial   The Lancet Respiratory Medicine

Other Guidance/Reports

2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines  Journal of the American College of Cardiology

Aerosol therapy in adult critically ill patients: a consensus statement regarding aerosol administration strategies during various modes of respiratory support  Annals of Intensive Care

British Thoracic Society Clinical Statement on pleural procedures  Thorax

British Thoracic Society Guideline for pleural disease  Thorax

ESPEN practical and partially revised guideline: Clinical nutrition in the intensive care unit  Clinical Nutrition

Expert consensus on blood pressure management in critically ill patients  Journal of Intensive Medicine

Extracorporeal blood purification therapies for sepsis-associated acute kidney injury in critically ill patients: expert opinion from the SIAARTI-SIN joint commission  Journal of Nephrology

Guideline on multimodal rehabilitation for patients with post-intensive care syndrome  Critical Care

Perceived Utility of Intracranial Pressure Monitoring in Traumatic Brain Injury: A Seattle International Brain Injury Consensus Conference Consensus-Based Analysis and Recommendations  Neurosurgery

Use of albumin infusion for cirrhosis-related complications: An international position statement  JHEP Reports


Duplex ultrasound for surveillance of lower limb revascularisation

Primary Research

A closed-loop ventilation mode that targets the lowest work and force of breathing reduces the transpulmonary driving pressure in patients with moderate-to-severe ARDS   Intensive Care Medicine Experimental

A new reservoir-based CPAP with low oxygen consumption: the Bag-CPAP  Critical Care

A novel method for assessment of airway opening pressure without the need for low-flow insufflation   Critical Care

A Rapid Systematic Review of Pharmacologic Sleep Promotion Modalities in the Intensive Care Unit   Journal of Intensive Care Medicine

A targeted metabolomics approach for sepsis-induced ARDS and its subphenotypes   Critical Care

A user evaluation of speech/phrase recognition software in critically ill patients: a DECIDE-AI feasibility study   Critical Care

Association between intrarenal venous flow from Doppler ultrasonography and acute kidney injury in patients with sepsis in critical care: a prospective, exploratory observational study   Critical Care

Asynchrony Injures Lung and Diaphragm in Acute Respiratory Distress Syndrome   Critical Care Medicine

Calibration of the PREdiction of DELIRium in ICu Patients (PRE-DELIRIC) Score in a Cohort of Critically Ill Patients – A Retrospective Cohort Study   Dimensions of Critical Care Nursing

Characteristics and Outcomes of Critically Ill Patients With Pulmonary Hypertension Who Undergo Endotracheal Intubation and Mechanical Ventilation   Journal of Intensive Care Medicine

Correlation between tissue Doppler-derived left ventricular systolic velocity (S’) and left ventricle ejection fraction in sepsis and septic shock: a retrospective cohort study   Journal of Intensive Care

Correlation of the Critical Care Pain Observation Tool and Numeric Rating Scale in Intensive Care Unit Patients   Journal of Intensive Care Medicine

Defining critical illness using immunological endotypes in patients with and without sepsis: a cohort study   Critical Care

Definition and Clinical Evaluation for Trimethoprim-Sulfamethoxazole Severe Acute Respiratory Failure  Critical Care Medicine

Development and validation of the creatinine clearance predictor machine learning models in critically ill adults   Critical Care

Development of a menu of recovery goals to facilitate goal setting after critical illness  Intensive and Critical Care Nursing

Discordance Between Invasive and NonInvasive Oxygen Saturation in Critically Ill COVID-19 Patients   Journal of Intensive Care Medicine

Echocardiography phenotypes of right ventricular involvement in COVID-19 ARDS patients and ICU mortality: post-hoc (exploratory) analysis of repeated data from the ECHO-COVID study   Intensive Care Medicine

Effect of Norepinephrine on Peripheral Perfusion Index and Its Association With the Prognosis of Patients With Sepsis   Journal of Intensive Care Medicine

Elevated MMP-8 levels, inversely associated with BMI, predict mortality in mechanically ventilated patients: an observational multicenter study   Critical Care

Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study   Intensive Care Medicine

Evaluation of Atypical Antipsychotics for the Facilitation of Weaning Sedation in Mechanically Ventilated Critically Ill Patients   Journal of Intensive Care Medicine

Evaluation of Proenkephalin A 119–159 for liberation from renal replacement therapy: an external, multicenter pilot study in critically ill patients with acute kidney injury  Critical Care

Factors associated with 30-day in-hospital mortality in critically ill adult patients receiving extracorporeal membrane oxygenation: A retrospective cohort study  Intensive and Critical Care Nursing

High Prevalence of Small Intestinal Bacterial Overgrowth Syndrome in ICU Patients: An Observational Study   Journal of Intensive Care Medicine

How clinicians discuss patients’ donor registrations of consent and presumed consent in donor conversations in an opt-out system: a qualitative embedded multiple-case study   Critical Care

Identification of indications for albumin administration in septic patients with liver cirrhosis  Critical Care

Intermittent body composition analysis as monitoring tool for muscle wasting in critically ill COVID-19 patients   Annals of Intensive Care

Machine learning predicts lung recruitment in acute respiratory distress syndrome using single lung CT scan   Annals of Intensive Care

Monitoring delirium in the intensive care unit: Diagnostic accuracy of the CAM-ICU tool when performed by certified nursing assistants – A prospective multicenter study   Intensive and Critical Care Nursing

Plasma protein biomarkers reflective of the host response in patients developing Intensive Care Unit-acquired pneumonia   Critical Care

Practice-Pattern Variation in Sedation of Neurotrauma Patients in the Intensive Care Unit: An International Survey   Journal of Intensive Care Medicine

Prevalence and risk factors for colonisation and infection with carbapenem-resistant Enterobacterales in intensive care units: A prospective multicentre study  Intensive and Critical Care Nursing

Prevalent diabetes and long-term cardiovascular outcomes in adult sepsis survivors: a population-based cohort study   Critical Care

Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients   Intensive Care Medicine

Profiling and Benchmarking Central Nervous System Infections in an Infectious Diseases Intensive Care Unit   Journal of Intensive Care Medicine

Prognostic and predictive value of endothelial dysfunction biomarkers in sepsis-associated acute kidney injury: risk-stratified analysis from a prospective observational cohort of pediatric septic shock  Critical Care

Results from 237 extracorporeal membrane oxygenation runs with drowned patients: a nationwide retrospective study   Critical Care

Sepsis-associated acute kidney injury in the intensive care unit: incidence, patient characteristics, timing, trajectory, treatment, and associated outcomes. A multicenter, observational study   Intensive Care Medicine

Suffering in silence – Cardiac surgery patients recalling hypoactive delirium a qualitative descriptive study   Intensive and Critical Care Nursing

The carbon footprint of Bubble-PAPR™: A novel item of personal protective equipment   Journal of the Intensive Care Society

The metabolic cost of inspiratory muscle training in mechanically ventilated patients in critical care  Intensive Care Medicine Experimental

The predictive value of the modified early warning score for admission to the intensive care unit in patients with a hematologic malignancy – A multicenter observational study   Intensive and Critical Care Nursing

Towards model-informed precision dosing of piperacillin: multicenter systematic external evaluation of pharmacokinetic models in critically ill adults with a focus on Bayesian forecasting   Intensive Care Medicine

Trauma-induced disturbances in ionized calcium levels correlate parabolically with coagulopathy, transfusion, and mortality: a multicentre cohort analysis from the TraumaRegister DGU®  Critical Care

Using metabolomics to predict severe traumatic brain injury outcome (GOSE) at 3 and 12 months  Critical Care


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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